Primary Squamous-Cell Carcinoma of the Ovary: A Report of 2 Cases and Review of the Literature

Abstract

Abstract

Background: Primary squamous-cell carcinoma (SCC) of the ovary is a rare entity among gynecologic malignancies. Most primary squamous tumors of the ovary arise from malignant transformation of dermoid cysts. These tumors may also be associated with Brenner tumors or with endometriosis. Pure primary SCC of the ovary is extremely rare. As a result of the limited number of cases, there is a paucity of literature about the risk factors, clinical features, and effective treatment for these tumors. Prognosis is dismal for patients with advanced-stage disease, and even patients with earlier stage disease have uncertain outcomes based on previous reports. Cases: The article reports on 2 cases of primary SCC of the ovary, 1 that was stage IIA and another 1 that was stage IIIC. The presentation, diagnosis, treatment, and current outcome are discussed in this report. Results: Both patients underwent surgery and chemotherapy and remained disease-free as of the writing of this report. Conclusions: Primary SCC of the ovary is extremely rare, as has been reported; the condition does indeed have an uncertain prognosis. (J GYNECOL SURG 32:143)