Background: Colon cancer rarely mimics colon cancer, given that this type of cancer rarely metastasizes to the female genital tract. This case report describes a rare recurrence of colon cancer presenting with symptoms of primary endometrial cancer. Case: A 40-year-old woman had undergone colon resection for sigmoid-colon cancer 4 years prior to being admitted to the current authors' gynecology clinic because she had vaginal bleeding. An endometrial biopsy revealed metastases of colon adenocarsinoma. As noted on whole-body positron emission tomography/computerized tomography (PET /CT), the hypermethabolic malign involvement was located only in the patient's endometrium. Total abdominal hysterectomy and bilateral salpingo-opherectomy (TAH+BSO) was performed. Based on the pathologic examination of specimen that was removed surgically, a final diagnosis of sigmoid-colon cancer metastasis was confirmed. Results: Follow-up PET/CT did not show any evidence of malignancy. Conclusions: When a patient presents with abnormal vaginal bleeding and has a history of colorectal carcinoma, an unusual metastasis to the endometrium should be considered. (J GYNECOL SURG 29:262)
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