Correlation of Cellular Patterns in Proliferative Epithelial Lesions of the Uterine Tube with Lesions in the Ovary: A Histopathologic Study

Abstract

Abstract

Objective: The study was conducted with the objective of correlating the proliferative epithelial lesions of the uterine tube with various benign and malignant ovarian pathologies. Design: The study included 62 specimens of panhysterectomy or hysterectomy with unilateral salpingo-oophorectomy with primary lesions in the ovary. Materials and Methods: The histologic changes in the uterine tubes were studied for three groups of epithelial abnormalities: benign tubal hyperplasia (BTH), atypical tubal hyperplasia (ATH), and carcinoma in situ (CIS), judged by the following characteristics: nuclear crowding, stratification of nuclei, loss of polarity, nuclear atypia, mitoses, papillae (papillary formation), solid proliferation, inflammation, and acidophilic metaplasia. Results: Proliferative epithelial lesions of one type or another were found in the great majority of cases with a lesion in the ovaries, varying from 50% (with germ cell tumors) to 100% (with sex cord stromal tumors). In cases with proliferative lesions, all cases (100%) of benign surface epithelial tumors and borderline surface epithelial tumor of the serous type were associated with benign hyperplasia; whereas lesions were of high grade (ATH and CIS) when found in association with malignant surface epithelial tumors. Conclusions: ATH and CIS (moderate to severe) were seen in association with malignancies in the ovary. ATH and CIS should be considered as distinct clinical entities. (J GYNECOL SURG 28:1)