Local Vasoconstrictive Effect of Ornipressin (POR8) in Laser Conization of the Cervix: A Randomized Study

Abstract

ABSTRACT

To evaluate the amount of bleeding in patients who underwent laser excision of the transformation zone, the ectocervix was infiltrated with 30 ml of a 1:30 ratio of ornipressin (POR8)-lignocaine 1% solution rather than with a 1% 30 ml solution of lignocaine alone. One hundred women undergoing CO₂ laser excision of the transformation zone for cervical intraepithelial neoplasia (CIN) were randomly allocated to one of two groups (A, POR8-lignocaine group, B, lignocaine group). A standard protocol that included operative technique, estimation of blood loss, operative time, pain, and morbidity was used. Statistical analysis was performed using Student's t-test, chi square, and the Fisher's exact test. The use of 30 ml of a 1:30 POR8-lignocaine 1% solution resulted in less intraoperative blood loss (30.25 ± 3.1 ml vs. 39 ± 5.2 ml, p < 0.001). The operative time was 17.5 ± 1.20 min in group A vs. 25.25 ± 2.5 min in group B. The dimension of the excised specimens were similar. No statistical difference was found in the two groups regarding the pain experienced. No electrocardiographic anomaly was recorded. Blood pressure was moderately elevated in the POR8 group (p < 0.3 by Fisher's exact test). Infiltration of the ectocervix with 30 ml of a 1:30 POR8-lignocaine 1% solution reduced the amount of blood loss during laser excision of the transformation zone. (J GYNECOL SURG 13:187, 1997)