Abstract
ABSTRACT
We compared the results of tubal anastomosis performed by a microsurgical technique and by the application of cyanoacrylate, a tissue adhesive agent. Forty Spraque-Dawley female rats were reared under identical conditions and divided into four groups of 10 rats each. In the first group, all the rats underwent a lower midline vertical incision followed by closure of the abdomen using 3-0 Vicryl. In the second group, anastomosis of the left uterine horn was performed by using cyanoacrylate. The right horn was anastomosed microsurgically with 8-0 Prolene sutures. In the third group, the uterine horn was anastomosed with cyanoacrylate, and the left horn was ligated. In the fourth group, the right horn was anastomosed by microsurgical technique, and the left horn was ligated. After mating, a repeat laparotomy was performed to evaluate the number of pregnancies, the presence and severity of adhesion formation, and histopathologic changes induced by both techniques. Although there was no difference between the two methods with respect to corpus luteum formation in the ovaries and the number of embryos, the number of pregnancies was higher when microsurgical techniques were used. The severity of adhesion formation was greater after cyanoacrylate application than after microsurgery, and this could be the reason for the higher pregnancy number in the microsurgery group. Cyanoacrylate application is a simple and time-saving procedure. Based on these findings in the rat, a prospective trial in the human would be warranted. This may be an alternative to microsurgery in tubal end-to-end anastomosis. (J GYNECOL SURG 12:261, 1996)
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