Abstract
ABSTRACT
To evaluate the effects of Ringer's lactate instillation and amniotic membrane on adhesion formation and reformation, 30 Sprague-Dawley rats were subjected to a standardized lesion by serosal denudation of the proximal uterine horn and devascularization of that segment. The rats were assigned randomly into control, Ringer's lactate, and amniotic membrane groups. The amniotic membrane was first treated with trypsin. At the second laparotomy, adhesions were scored and liberated, and the rats with adhesion score of more than 4 were assigned randomly into the three groups as previously described. Adhesion formation and reformation were significantly lower in the Ringer's lactate than in the control group. The adhesion formation score was higher in the control group than in the amniotic membrane group. The adhesion reformation score, however, was not significantly different. These findings suggest that in our animal model, Ringer's lactate instillation reduces adhesion formation and reformation. Trypsin-treated amniotic membrane reduces adhesion formation but not reformation. (J GYNECOL SURG 8:247, 1992)
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