Abstract
Background:
A consensus is building that interleukin-10 (IL-10), as a multifunctional anti-inflammatory cytokine, has a critical influence in cancer development. A meta-analysis was carried out regarding the relationships among the -592 A/C, -1082 G/A, and -819 T/C IL-10 polymorphisms and their association with skin squamous cell carcinoma (sSCC), melanoma, and basal cell carcinoma (BCC).
Materials and Methods:
A meta-analysis was carried out to study the inter-relationships among three IL-10 SNPs and their association with sSCC, melanoma, and BCC.
Results:
In this analysis, a total of 11 researches, involving 2149 controls and 2128 cases, were included. No association was found between skin cancer risk and any of the alleles of either the -592A/C SNP or the 1082T/C SNP. However, a moderately decreased skin cancer risk was found in the -819 TC versus CC model (odds ratio [OR] = 0.81 and 95% confidence interval [CI] = 0.67-0.99, p = 0.04). From the subgroup analysis, a decreased risk was found between the studies of nonmelanoma skin cancers and IL-10-819T/C in the dominant model (OR = 0.60, 95% CI = 0.43-0.85, p = 0.004 for TT+TC vs. CC). Egger's and Begg's tests demonstrated that there was no significant publication bias.
Conclusion:
This meta-analysis showed that there is an association between risk of non-melanoma skin cancers (BCC & sSCC) and the IL-10 -819T/C polymorphism, but that IL-10 -polymorphisms -592A/C and -1082G/A are unlikely to be risk factors for any of the evaluated skin cancers including melanoma.
Get full access to this article
View all access options for this article.