Sage Journals: Discover world-class research

Abstract

Background:

The oxoguanine DNA glycosylase (OGG1) Ser326Cys polymorphism has been implicated in susceptibility to esophageal cancer. Several studies investigated the association of this polymorphism with esophageal cancer in different populations. However, the results were contradictory. A meta-analysis was conducted to assess the association between the OGG1 Ser326Cys polymorphism and esophageal cancer susceptibility.

Methods:

Databases, including PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and Weipu Database were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. A random-effects model was used.

Results:

Twelve studies involving 2363 cases and 3621 controls were included. Overall, a significant association between the OGG1 Ser326Cys polymorphism and esophageal cancer was observed for Cys/Cys versus Cys/Ser+Ser/Ser (OR=1.40; 95% CI 1.12-1.74; p=0.003; P_{heterogeneity}=0.18). In the subgroup analysis by ethnicity, a significant association was found among Asians (OR=1.51; 95% CI 1.15-1.96; p=0.002; P_{heterogeneity}=0.22), but not among Caucasians (OR=1.21; 95% CI 0.81-1.81; p=0.35; P_{heterogeneity}=0.21). In the subgroup analysis by pathologic type, we found that the Cys/Cys genotype was associated with increased esophageal squamous cell carcinoma risk (OR=1.86; 95% CI 1.36-2.53; p<0.0001; P_{heterogeneity}=0.73).

Conclusions

: This meta-analysis suggested that the OGG1 Ser326Cys polymorphism was a risk factor of esophageal cancer.

Get full access to this article

View all access options for this article.

References

Akbari

, Malekzadeh

, Shakeri

et al. 2009. Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran. Cancer Res, 69:7994-8000.

Asami

, Hirano

, Yamaguchi

et al. 1996. Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking. Cancer Res, 56:2546-2549.

Boiteux

, Radicella

. 2000. The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis. Arch Biochem Biophys, 377:1-8.

Chen

, Ding

, Yang

G-y

et al. 2000. Oxidative damage in an esophageal adenocarcinoma model with rats. Carcinogenesis, 21:257-263.

Cheng

, Cahill

, Kasai

et al. 1992. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G——T and A——C substitutions. J Biol Chem, 267:166-172.

Egger

, Smith

, Schneider

et al. 1997. Bias in meta-analysis detected by a simple, graphical test. BMJ, 315:629-634.

Ferguson

, Wild

, Anderson

et al. 2008. No association between hOGG1, XRCC1, and XPD polymorphisms and risk of reflux esophagitis, Barrett's esophagus, or esophageal adenocarcinoma: results from the factors influencing the Barrett's adenocarcinoma relationship case-control study. Cancer Epidemiol Biomarkers Prev, 17:736-739.

Gao

, Haruhiko

, Toshiro

. 2001. hOGG1 genotypes, life style and the risk of esophageal and stomach cancers. Bull Chin Cancer, 10:500-502.

Hall

, Hashibe

, Boffetta

et al. 2007. The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract. Carcinogenesis, 28:665-671.

10.

Hecht

. 1999. Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst, 91:1194-1210.

11.

Howard

, Ota

, Briggs

et al. 1998. Environmental tobacco smoke in the workplace induces oxidative stress in employees, including increased production of 8-hydroxy-2′-deoxyguanosine. Cancer Epidemiol Biomarkers Prev, 7:141-146.

12.

, Wu

, Jin

et al. 2010. OGG1 Ser326Cys polymorphism and susceptibility to esophageal cancer in YuBei. Shandong Yi Yao, 50:49-50.

13.

Kasai

, Chung

, Jones

et al. 1991. 8-Hydroxyguanine, a DNA adduct formed by oxygen radicals: its implication on oxygen radical-involved mutagenesis/carcinogenesis. J Toxicol Sci, 16:95-105.

14.

Kiyosawa

, Suko

, Okudaira

et al. 1990. Cigarette smoking induces formation of 8-hydroxydeoxyguanosine, one of the oxidative DNA damages in human peripheral leukocytes. Free Radic Res, 11:23-27.

15.

Kohno

, Shinmura

, Tosaka

et al. 1998. Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA. Oncogene, 16:3219-3225.

16.

Lagadu

, Lechevrel

, Sichel

et al. 2010. 8-oxo-7,8-dihydro-2′-deoxyguanosine as a biomarker of oxidative damage in oesophageal cancer patients: lack of association with antioxidant vitamins and polymorphism of hOGG1 and GST. J Exp Clin Cancer Res, 29:157.

17.

Liu

, Wu

, Chen

et al. 2010. A large-scale genetic association study of esophageal adenocarcinoma risk. Carcinogenesis, 31:1259-1263.

18.

Liu

, Ying

, Pu

et al. 2005. Relationship between human 8-hydroxyguanine glycosylase Ser32Cys gene polymorphism and esophageal cancer. Chin J Public Health, 21:1430-1432.

19.

Marnett

. 2000. Oxyradicals and DNA damage. Carcinogenesis, 21:361-370.

20.

Nasrollahzadeh

, Kamangar

, Aghcheli

et al. 2008. Opium, tobacco, and alcohol use in relation to oesophageal squamous cell carcinoma in a high-risk area of Iran. Br J Cancer, 98:1857-1863.

21.

Nie

, Chen

, Xiu

. 2012a. Cytotoxic T-lymphocyte associated antigen 4 polymorphisms and asthma risk: a meta-analysis. PLoS One, 7:e42062.

22.

Nie

, Fang

, Li

et al. 2012b. Interleukin-10 promoter polymorphisms and asthma risk: a meta-analysis. Cytokine, 60:849-855.

23.

Nie

, Liu

, Bian

et al. 2013a. Effects of polymorphisms-1112C/T and +2044A/G in interleukin-13 gene on asthma risk: a meta-analysis. PLoS One, 8:e56065.

24.

Nie

, Zhu

, Pan

et al. 2013b. The interleukin-4-589C/T polymorphism and the risk of asthma: A meta-analysis including 7345 cases and 7819 controls. Gene, 520:22-29.

25.

Parkin

, Bray

, Ferlay

et al. 2005. Global cancer statistics, 2002. CA Cancer J Clin, 55:74-108.

26.

Shen

H-M

, Chia

S-E

, Ni

Z-Y

et al. 1997. Detection of oxidative DNA damage in human sperm and the association with cigarette smoking. Reprod Toxicol, 11:675-680.

27.

Shibutani

, Takeshita

, Grollman

. 1991. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature, 349:431-434.

28.

Sunaga

, Kohno

, Shinmura

et al. 2001. OGG1 protein suppresses G: C→T: A mutation in a shuttle vector containing 8-hydroxyguanine in human cells. Carcinogenesis, 22:1355-1362.

29.

Thakkinstian

, McElduff

, D'Este

et al. 2005. A method for meta-analysis of molecular association studies. Stat Med, 24:1291-1306.

30.

Tse

, Zhai

, Zhou

et al. 2008. Polymorphisms of the NER pathway genes, ERCC1 and XPD are associated with esophageal adenocarcinoma risk. Cancer Causes Control, 19:1077-1083.

31.

Upadhyay

, Malik

, Zargar

et al. 2010. OGG1 Ser326Cys polymorphism and susceptibility to esophageal cancer in low and high at-risk populations of northern India. J Gastrointest Cancer, 41:110-115.

32.

Vaughan

, Davis

, Kristal

et al. 1995. Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev, 4:85-92.

33.

Xing

, Tan

, Song

et al. 2001. Ser326Cys polymorphism in hOGG1 gene and risk of esophageal cancer in a Chinese population. Int J Cancer, 95:140-143.

34.

Zhu

, Zhang

, Du

et al. 2009. Association of hOGG1 polymorphism Ser326Cys between the susceptibility of esophageal cancer and its clinicopathological characteristics. J Environ Occup Med, 126:25-28.

The OGG1 Ser326Cys Polymorphism and the Risk of Esophageal Cancer: A Meta-Analysis