Polymorphisms −1082 G/A and −819 C/T in the Interleukin-10 Gene Are Not Associated with Gout Susceptibility in the Chinese Han Male Population

Abstract

Background: Gout is caused by monosodium urate crystal-induced inflammation of the joints and periarticular tissues. Interleukin 10 (IL-10) is an important immunoregulatory cytokine, levels of which can be influenced by functional single-nucleotide polymorphisms in the promoter. Objective: To investigate the association of −1082 G/A and −819 C/T polymorphisms in the IL-10 promoter with gout susceptibility in the Chinese Han male population. Methods: A case-control study was performed in 302 patients and 284 controls. Genotyping of IL-10 −1082 G/A and −819 C/T polymorphisms was performed by DNA sequencing techniques. An association analysis was analyzed by the χ² test. Results: No significant differences were found in −819T/C and −1082 A/G genotypic and allelic frequencies between gout cases and controls (for −819T/C, χ²=0.212, df=1, p=0.645 by genotype; χ²=0.079, df=1, p=0.779 by allele; for −1082 A/G, χ²=2.116, df=1, p=0.146 by genotype; χ²=1.854, df=1, p=0.173 by allele). Conclusions: IL-10 −1082 G/A and −819 C/T polymorphisms may not be associated with susceptibility to gout and thus do not play a major role in the development of gout in the Chinese Han male population.