Hypoxia-Inducible Factor-1 Alpha C1772T Gene Polymorphism and Glioma Risk: A Hospital-Based Case-Control Study from China

Abstract

Background: The hypoxia-inducible factor 1 alpha (HIF-1α) plays a major role in cancer progression. Aim: The aim of this study was to investigate the potential association between HIF-1α C1772T gene polymorphism and glioma risk. Methods: We conducted a hospital-based case-control study from China. A total of 300 subjects (150 glioma patients and 150 healthy controls) were recruited in this study. The peripheral blood samples were extracted. The polymerase chain reaction-restriction fragment length polymorphism method was used to test genotypes. Results: Glioma patients had a significantly lower frequency of CC genotype (odds ratio [OR] = 0.46, 95% confidence interval [CI] = 0.24, 0.91; p = 0.03) and C allele (OR = 0.49, 95% CI = 0.26, 0.91; p = 0.03) than controls. Glioma patients had a significantly higher frequency of CT genotype (OR = 2.13, 95% CI = 1.07, 4.25; p = 0.03) and T allele (OR = 2.05, 95% CI = 1.09, 3.83; p = 0.03) than controls. There were no significant differences in the distributions of HIF-1α C1772T gene polymorphism among glioma patients at different tumor type and stage. Conclusion: This study suggested that CT genotype and the T allele of HIF-1α C1772T gene polymorphism were associated with a higher glioma risk in the Han population of China.