Sage Journals: Discover world-class research

Abstract

Aims: DQA1 is a human leukocyte antigen (HLA) class II molecule that is similar to the other class II molecules DR and DP. This study is the first of its kind to describe the distribution of HLA-DQA1 alleles in Lebanon. Methods: HLA-DQA1 typing was detected using the polymerase chain reaction/sequence-specific priming method in 111 Lebanese individuals referred for HLA typing and possible bone marrow donation. Results: Our data was compared to that of several populations. Some similarities were found between the Lebanese, Tunisian, Spanish, and Kuwaiti populations. Conclusion: This very first report from Lebanon will be of great help for later research to study the association of DQA1 alleles with major diseases in the Lebanese population and will add to the published international literature related to this important histocompatibility locus.

Get full access to this article

View all access options for this article.

References

Alsaeid

, Haider

, Sharma

, Ayoub

. 2006. The prevalence of human leukocyte antigen (HLA) DR/DQ/DP alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis. Rheumatol Int, 26:224-228.

Amirzargar

, Mytilineos

, Farjadian

et al. 2001. Human leukocyte antigen class II allele frequencies and haplotype association in Iranian normal population. Hum Immunol, 62:1234-1238.

Ayed

, Ayed-Jendoubi

, Sfar

et al. 2004. HLA class-I and HLA class-II phenotypic, gene and haplotypic frequencies in Tunisians by using molecular typing data. Tissue Antigens, 64:520-532.

Begovich

, McClure

, Suraj

et al. 1992. Polymorphism, recombination, and linkage disequilibrium within the HLA class II region. J Immunol, 148:249-258.

Bowcock

, Kidd

, Mountain

et al. 1991. Drift, admixture, and selection in human evolution: a study with DNA polymorphisms. Proc Natl Acad Sci USA, 88:839-843.

Chakraborty

, Kidd

. 1991. The utility of DNA typing in forensic work. Science, 254:1735-1739.

Cortes

, Baltazar

, Perea

et al. 2004. HLA-DQB1, -DQA1, -DRB1 linkage disequilibrium and haplotype diversity in a Mestizo population from Guadalajara, Mexico. Tissue Antigens, 63:458-465.

Kapustin

, Lyshchov

, Alexandrova

et al. 1999. HLA class II molecular polymorphisms in healthy Slavic individuals from North-Western Russia. Tissue Antigens, 54:517-520.

Kaufman

, Auffray

, Korman

et al. 1984. The class II molecules of the human and murine major histocompatibility complex. Cell, 36:1-13.

10.

Kwok

, Kovats

, Thurtle

, Nepom

. 1993. HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation. J Immunol, 150:2263-2272.

11.

Linch

, Nadler

, Luther

, Lipton

. 1984. Discordant expression of human Ia-like antigens on hematopoietic progenitor cells. J Immunol, 132:2324-2329.

12.

Maciel

, Rodrigues

, Dibbern

et al. 2001. Association of the HLA-DRB1*0301 and HLA-DQA1*0501 alleles with Graves' disease in a population representing the gene contribution from several ethnic backgrounds. Thyroid, 11:31-35.

13.

Marrosu

, Murru

, Costa

et al. 1998. DRB1-DQA1-DQB1 loci and multiple sclerosis predisposition in the Sardinian population. Hum Mol Genet, 7:1235-1237.

14.

Moustakas

, Papadopoulos

. 2002. Molecular properties of HLA-DQ alleles conferring susceptibility to or protection from insulin-dependent diabetes mellitus: keys to the fate of islet beta-cells. Am J Med Genet, 115:37-47.

15.

Papassavas

, Spyropoulou-Vlachou

, Papassavas

et al. 2000. MHC class I and class II phenotype, gene, and haplotype frequencies in Greeks using molecular typing data. Hum Immunol, 61:615-623.

16.

Planelles

, Nagore

, Moret

et al. 2006. HLA class II polymorphisms in Spanish melanoma patients: homozygosity for HLA-DQA1 locus can be a potential melanoma risk factor. Br J Dermatol, 154:261-266.

17.

Price

, Witt

, Allcock

et al. 1999. The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases. Immunol Rev, 167:257-274.

18.

Yang

, Wang

, Gao

et al. 2005. Association of HLA-DQA1 and DQB1 genes with vitiligo in Chinese Hans. Int J Dermatol, 44:1022-1027.

19.

Zubillaga

, Vidales

, Zubillaga

et al. 2002. HLA-DQA1 and HLA-DQB1 genetic markers and clinical presentation in celiac disease. J Pediatr Gastroenterol Nutr, 34:548-554.

Human Leukocyte Antigen -DQA1 Gene Allelic Distribution: Experience of a Major Tertiary Care Center in Lebanon

Abstract

Get full access to this article

References