Without Fundamental Science,How Will the Next Generation of Novel Therapies Emerge?

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References

Schuhmacher

, Hinder

, Dodel

et al,. Investigating the origins of recent pharmaceutical innovation. Nat Rev Drug Discov. , 2023 Oct; 22(10):781–782. doi: 10.1038/d41573-023-00102-z. PMID: 37407752.

Mojsov

, Weir

, Habener

. Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest. , 1987 Feb; 79(2):616–9. doi: 10.1172/JCI112855. PMID: 3543057; PMCID: PMC424143.

Eng

, Kleinman

, Singh

et al,. Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. J Biol Chem. , 1992 Apr 15; 267(11):7402–5. PMID: 1313797.

Sankaran

, Menne

, Xu

et al,. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science . 2008 Dec 19; 322(5909):1839–42. doi: 10.1126/science.1165409. Epub 2008 Dec 4. PMID: 19056937.

Kozlov

. Revealed: NIH research grants still frozen despite lawsuits challenging Trump order. Nature . 2025 Feb; 638(8052):870–871. doi: 10.1038/d41586-025-00540-2. PMID: 39979573.

Wadman

, Kaiser J: Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring Researchers facing “a lot of uncertainty, fear, and panic. Science . 2025 Jan. doi: 10.1126/science.z7pm10i