ForsythKS, JiwrajkaN, LovellCD, et al.The conneXion between sex and immune responses. Nat Rev Immunol, 2024; doi: 10.1038/s41577-024-00996-9
3.
VinuesaCG, ShenN, WareT. Genetics of SLE: mechanistic insights from monogenic disease and disease-associated variants. Nat Rev Nephrol, 2023; 19(9):558–572; doi: 10.1038/s41581-023-00732-x
4.
SunL, WangZ, LuT, et al.eXclusionarY: 10 years later, where are the sex chromosomes in GWASs?. Am J Hum Genetics, 2023; 110(6):903–912; doi: 10.1016/j.ajhg.2023.04.009
5.
CaseLK, WallEH, OsmanskiEE, et al.Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring. Genome Biol, 2015; 16(1):28; doi: 10.1186/s13059-015-0591-7
6.
BrownCJ, BallabioA, RupertJL, et al.A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature, 1991; 349(6304):38–44; doi: 10.1038/349038a0
7.
MigeonBR. The role of X inactivation and cellular mosaicism in women's health and sex-specific diseases. JAMA, 2006; 295(12):1428–1433; doi: 10.1001/jama.295.12.1428
8.
WatsonCJ, BlundellJR. Mutation rates and fitness consequences of mosaic chromosomal alterations in blood. Nat Genet, 2023; 55(10):1677–1685; doi: 10.1038/s41588-023-01490-z
9.
AsseltaR, ParaboschiEM, GerussiA, et al.X chromosome contribution to the genetic architecture of primary biliary cholangitis. Gastroenterology, 2021; 160(7):2483–2495.e26; doi: 10.1053/j.gastro.2021.02.061
10.
ArnoldAP. Four core genotypes and XY* mouse models: Update on impact on SABV research. Neurosci Biobehav Rev, 2020; 119(6):1–8; doi: 10.1016/j.neubiorev.2020.09.021
11.
PyfromS, PaneruB, KnoxJJ, et al.The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients. Proc Natl Acad Sci U S A, 2021; 118(24):e2024624118; doi: 10.1073/pnas.2024624118
12.
YuB, QiY, LiR, et al.B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells. Cell, 2021; 184(7):1790–1803.e17; doi: 10.1016/j.cell.2021.02.015
13.
WutzA, RasmussenTP, JaenischR. Chromosomal silencing and localization are mediated by different domains of Xist RNA. Nat Genet, 2002; 30(2):167–174; doi: 10.1038/ng820
14.
BrownCJ, HendrichBD, RupertJL, et al.The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell, 1992; 71:527–542.
15.
BrooksWH, SatohM, HongB, et al.Autoantibodies from an SLE patient immunostain the Barr body. Cytogenet Genome Res, 2002; 97(1–2):28–31; doi: 10.1159/000064039
16.
McHughCA, ChenC-K, ChowA, et al.The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3. Nature, 2015; 521(7551):232–236; doi: 10.1038/nature14443
17.
MinajigiA, FrobergJE, WeiC, et al.A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation. Science, 2015; 349(6245):aab2276; doi: 10.1126/science.aab2276
18.
ChuC, ZhangQC, da RochaST, et al.Systematic discovery of Xist RNA binding proteins. Cell, 2015; 161(2):404–416; doi: 10.1016/j.cell.2015.03.025
19.
ValledorM, ByronM, DumasB, et al.Early chromosome condensation by XIST builds A-repeat RNA density that facilitates gene silencing. Cell Rep, 2023; 42(7):112686; doi: 10.1016/j.celrep.2023.112686
20.
DunnSE, PerryWA, KleinSL. Mechanisms and consequences of sex differences in immune responses. Nat Rev Nephrol, 2024; 20(1):37–55; doi: 10.1038/s41581-023-00787-w
21.
RomanAKS, SkaletskyH, GodfreyAK, et al.The human Y and inactive X chromosomes similarly modulate autosomal gene expression. Cell Genom, 2024; 4(1):100462; doi: 10.1016/j.xgen.2023.100462
22.
DrorI, ChitiashviliT, TanSYX, et al.XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells. Cell, 2024; 187(1):110–129.e31; doi: 10.1016/j.cell.2023.11.033
23.
LiuY, SinkeL, JonkmanTH, et al.The inactive X chromosome accumulates widespread epigenetic variability with age. Clin Epigenetics, 2023; 15(1):135; doi: 10.1186/s13148-023-01549-y