McDonnellDP, VegetoE, GleesonMA. Nuclear hormone receptors as targets for new drug discovery. Nat Biotechnol, 1993; 11(11):1256–1261; doi: 10.1038/nbt1193-1256
2.
MurrayMH, ValfortAC, KoelblenT, et al.Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB. Nat Commun, 2022; 13(1):7131; doi: 10.1038/s41467-022-34892-4
3.
LazarMA, HodinRA, DarlingDS, et al.A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit. Mol Cell Biol, 1989; 9(3):1128–1136; doi: 10.1128/mcb.9.3.1128-1136.1989
4.
RaghuramS, StayrookKR, HuangP, et al.Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. Nat Struct Mol Biol, 2007; 14(12):1207–1213; doi: 10.1038/nsmb1344
5.
RuanW, YuanX, EltzschigHK. Circadian rhythm as a therapeutic target. Nat Rev Drug Discov, 2021; 20(4):287–307; doi: 10.1038/s41573-020-00109-w
CunninghamPS, MeijerP, NazgiewiczA, et al.The circadian clock protein REVERBα inhibits pulmonary fibrosis development. Proc Natl Acad Sci U S A, 2020; 117(2):1139–1147; doi: 10.1073/pnas.1912109117
8.
MengQJ, McMasterA, BeesleyS, et al.Ligand modulation of REV-ERBalpha function resets the peripheral circadian clock in a phasic manner. J Cell Sci, 2008; 121(Pt 21):3629–3635; doi: 10.1242/jcs.035048
9.
GrantD, YinL, CollinsJL, et al.GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. ACS Chem Biol, 2010; 5(10):925–932; doi: 10.1021/cb100141y
10.
GibbsJE, BlaikleyJ, BeesleyS, et al.The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines. Proc Natl Acad Sci U S A, 2012; 109(2):582–587; doi: 10.1073/pnas.1106750109
11.
NoelR, SongX, ShinY, et al.Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists. Bioorg Med Chem Lett, 2012; 22(11):3739–3742; doi: 10.1016/j.bmcl.2012.04.023
12.
SoltLA, WangY, BanerjeeS, et al.Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature, 2012; 485(7396):62–68; doi: 10.1038/nature11030
13.
ChangC, LooC-S, ZhaoX, et al.The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease. Proc Natl Acad Sci U S A, 2019; 116(37):18528–18536; doi: 10.1073/pnas.1907563116
DierickxP, EmmettMJ, JiangC, et al.SR9009 has REV-ERB–independent effects on cell proliferation and metabolism. Proc Natl Acad Sci U S A, 2019; 116(25):12147–12152; doi: 10.1073/pnas.1904226116
16.
AmirM, ChaudhariS, WangR, et al.REV-ERBα regulates TH17 cell development and autoimmunity. Cell Rep, 2018; 25(13):3733–3749.e8; doi: https://doi.org/10.1016/j.celrep.2018.11.101
17.
ZhaoZ, UkidveA, KimJ, et al.Targeting strategies for tissue-specific drug delivery. Cell, 2020; 181(1):151–167; doi: 10.1016/j.cell.2020.02.001
18.
FergusonLT, MaX, MyersonJW, et al.Mechanisms by which liposomes improve inhaled drug delivery for alveolar diseases. Adv NanoBiomed Res, 2023; 2200106; doi: https://doi.org/10.1002/anbr.202200106
