ChiuJ, ValenteKN, LevyNE, et al.Knockout of a difficult-to-remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoclonal antibody formulations. Biotechnol. Bioeng. 2017; 114(5): 1006–1015. DOI: 10.1002/bit.26237.
2.
HallT, SandefurSL, FryeCC, et al.Polysorbates 20 and 80 Degradation by Group XV Lysosomal Phospholipase A2 Isomer X1 in Monoclonal Antibody Formulations. J. Pharm. Sci., 2016; 105(5): 1633–1642. DOI: 10.1016/j.xphs.2016.02.022.
3.
JonesM, PalackalN, WangF, et al.“High-risk” host cell proteins (HCPs): A multi-company collaborative view. Biotechnol. Bioeng., 2021; 118(8): 2870–2885. DOI: 10.1002/bit.27808.
