FordyceCB, RoeMT, AhmadT, et al.Cardiovascular Drug Development: Is It Dead or Just Hibernating?. J. Am. Coll. Cardiol. 2015; 65: 1567–1582.
2.
ThomasD, WesselC. The State of Innovation in Highly Prevalent Chronic Diseases. Volume V: Systemic Hypertension and Congestive Heart Failure. BIO Industry Analysis Report (Highly Prevalent Chronic Disease Series). BIO; 2020.
3.
DowningNS, AminawungJA, ShahND, et al.Clinical Trial Evidence Supporting FDA Approval of Novel Therapeutic Agents, 2005–2012. 2014; JAMA, 311: 368–377.
JacksonN, AtarD, BorentainM, et al.Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology. Eur. Heart J. 2016; 37: 747–754.
8.
EderJ, SedraniR, WiesmannC. The discovery of first-in-class drugs: origins and evolution. Nat. Rev. Drug Discov., 2014; 13: 577–587.
9.
AitkenM, KleinrockM. Orphan Drugs in the United States: Exclusivity, Pricing and Treated Populations. IQVIA Institute for Human Data Science. December2018.