High-Quality Hits from High-Throughput Screens

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References

Baell

J.B.

, Holloway

G.A.

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays. J. Med. Chem. , 2010; 53(7): 2719–2740. DOI: 10.1021/jm901137j

Capuzzi

S.J.

, Muratov

E.N.

, Tropsha

. Phantom PAINS: Problems with the Utility of Alerts for PAn-Assay INterference CompoundS. J. Chem. Inf. Model. , 2017; 57(3): 417–427. DOI: 10.1021/acs.jcim.6b00465

Segall

M.D.

Multi-Parameter Optimization: Identifying High-Quality Compounds with a Balance of Properties. Curr. Pharm. Des. , 2012; 18(9): 1292–1310. DOI: 10.2174/138161212799436430