Previous economic estimates of infection with Toxoplasma gondii and chronic sequelae following infection lack sufficient data to establish the true burden of disease and its chronic sequelae. This scoping review aims to fill this gap by updating existing literature regarding the development of postinfectious sequelae following T. gondii infection. Literature published between January 1, 2000, and November 6, 2018, in PubMed, EMBASE, and Scopus was searched for a wide range of postinfectious sequelae and economic estimate terms. This scoping review includes summaries from the 108 articles covering 5 main groupings of outcomes (categories are not exclusive) including vision disorders (n = 58), psychological and mental health disorders (n = 27), neurological disorders (n = 17), fetal death and infection (n = 15), and hearing loss (n = 6), as well as a description of other outcomes reported. While the majority of the included studies assessed the incidence of these outcomes postinfection, very few followed participants long-term. These prospective studies are needed to understand the true burden of postinfectious sequelae over the life course, particularly because congenital infection with Toxoplasma can lead to severe outcomes for newborns. This scoping review can be used as an important resource for other researchers wishing to conduct future systematic reviews and meta-analyses, as well as for policy makers interested in developing guidance for public and health care partners.
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References
1.
ArkseyH, O'MalleyL. Scoping studies: Towards a methodological framework. Int J Soc Res Methodol, 2005; 8:19–32.
2.
Barisani-AsenbauerT, MacASM, MejdoubiL, EmmingerW, MacHoldK, AuerH. Uveitis- a rare disease often associated with systemic diseases and infections: A systematic review of 2619 patients. Orphanet J Rare Dis, 2012; 7:57.
3.
BayaniM, RiahiSM, BazrafshanN, Ray GambleH, RostamiA. Toxoplasma gondii infection and risk of Parkinson and Alzheimer diseases: A systematic review and meta-analysis on observational studies. Acta Trop, 2019; 196:165–171.
4.
BrownED, ChauJK, AtashbandS, WesterbergBD, KozakFK. A systematic review of neonatal toxoplasmosis exposure and sensorineural hearing loss. Int J Pediatr Otorhinolaryngol, 2009; 73:707–711.
5.
Cañón-FrancoWA, López-OrozcoN, Gómez-MarínJE, DubeyJP. An overview of seventy years of research (1944–2014) on toxoplasmosis in Colombia, South America. Parasit Vectors, 2014; 7:427.
6.
ChegeniTN, SarviS, AmoueiA, MoosazadehM, HosseininejadZ, AghayanSA, DaryaniA. Relationship between toxoplasmosis and obsessive compulsive disorder: A systematic review and meta-analysis. PLoS Negl Trop Dis, 2019a;13:e0007306.
7.
ChegeniTN, SharifM, SarviS, MoosazadehM, MontazeriM, AghayanSA, BalalamiNJ, GholamiS, HosseininejadZ, SaberiR, AnvariD, GohardehiS, DaryaniA. Is there any association between Toxoplasma gondii infection and depression? A systematic review and meta-analysis. PLoS One, 2019b;14:e0218524.
de BarrosJLVM, BarbosaIG, SalemH, RochaNP, KummerA, OkusagaOO, SoaresJC, TeixeiraAL. Is there any association between Toxoplasma gondii infection and bipolar disorder? A systematic review and meta-analysis. J Affect Disord, 2017; 209:59–65.
10.
de-la-TorreA, López-CastilloCA, RuedaJC, MantillaRD, Goemez-MarÚnJE, AnayaJM. Clinical patterns of uveitis in two ophthalmology centres in Bogota, Colombia. Clin Exp Ophthalmol, 2009a;37:458–466.
11.
de-la-TorreA. Incidence and clinical characteristics in aColombian cohort of ocular toxoplasmosis. 2009b. doi:10.1038/eye.2008.219
12.
DubeyJP, LagoEG, GennariSM, SuC, JonesJL. Toxoplasmosis in humans and animals in Brazil: High prevalence, high burden of disease, and epidemiology. Parasitology, 2012; 139:1375–1424.
13.
FurtadoJM, SmithJR, BelfortR, GatteyD, WinthropKL. Toxoplasmosis: A global threat. J Glob Infect Dis, 2011; 3: 281–284.
14.
GeethaR, TripathyK. Chorioretinitis. Treasure Island, FL:StatPearls Publishing, 2021.
15.
GohardehiS, SharifM, SarviS, MoosazadehM, Alizadeh-NavaeiR, HosseiniSA, AmoueiA, PaghehA, SadeghiM, DaryaniA. The potential risk of toxoplasmosis for traffic accidents: A systematic review and meta-analysis. Exp Parasitol, 2018; 191:19–24.
HavelaarAH, HaagsmaJA, MangenMJJ, KemmerenJM, VerhoefLPB, VijgenSMC, WilsonM, FriesemaIH, KortbeekLM, van DuynhovenYT, van PeltW. Disease burden of foodborne pathogens in the Netherlands, 2009. Int J Food Microbiol, 2012; 156:231–238.
HoffmannS, BatzMB, MorrisJJG. Annual cost of illness and quality-adjusted life year losses in the United States due to 14 foodborne pathogens. J Food Prot, 2012; 75:1292–302.
21.
HoffmannS, Scallan WalterE. Acute complications and sequelae from foodborne infections: Informing priorities for cost of foodborne illness estimates. Foodborne Pathog Dis, 2020; 17:172–177.
22.
JonesJL, HollandGN. Short report: Annual burden of ocular toxoplasmosis in the United States. Am J Trop Med Hyg, 2010; 82:464–465.
23.
JonesJL, Kruszon-MoranD, Sanders-LewisK, WilsonM. Toxoplasma gondii infection in the United States, 1999–2004, decline from the prior decade. Am J Trop Med Hyg, 2007; 77:405–410.
24.
KhandakerGM, ZimbronJ, LewisG, JonesPB. Prenatal maternal infection, neurodevelopment and adult schizophrenia: A systematic review of population-based studies. Psychol Med, 2013; 43:239–257.
25.
KortbeekLM, HofhuisA, NijhuisCDM, HavelaarAH. Congenital toxoplasmosis and DALYs in the Netherlands. Mem Inst Oswaldo Cruz, 2009; 104:370–373.
26.
LiXL, WeiHX, ZhangH, PengHJ, LindsayDS. A meta analysis on risks of adverse pregnancy outcomes in Toxoplasma gondii infection. PLoS One, 2014; 9:97775.
27.
MajidianiH, DalvandS, DaryaniA, De LaM, Galvan-RamirezL, Foroutan-RadM. Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case-control studies. Braz J Infect Dis, 2016; 20:605–609.
28.
MangenMJJ, BouwknegtM, FriesemaIHM, HaagsmaJA, KortbeekLM, TariqL, WilsonM, van PeltW, HavelaarAH. Cost-of-illness and disease burden of food-related pathogens in the Netherlands, 2011. Int J Food Microbiol, 2015; 196:84–93.
29.
MunnZ, PetersM, SternC, TufanaruC, McArthurA, AromatarisE. Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach. BMC Med Res Methodol, 2018; 18:143.
30.
NgoungouEB, BhallaD, NzogheA, DardéML, PreuxPM. Toxoplasmosis and epilepsy—Systematic review and meta analysis. PLoS Negl Trop Dis, 2015; 9:e0003525.
31.
NissenJ, JokelainenP, StensvoldCR, TrevisanC, FuchsJ, BurgdorfKS, NielsenHV, PiresSM. The disease burden of congenital toxoplasmosis in Denmark, 2014. PLoS One, 2017; 12:e0178282.
32.
Owusu-DommeyA, Pogreba-BrownK, Villa-ZapataL. Seroprevalence of Toxoplasma gondii in the U.S.: Evidence from a representative cross-sectional survey. Parasitol Int, 2020; 79:102175.
33.
Pinto-FerreiraF, CaldartET, PasqualiAKS, Mitsuka-BreganóR, FreireRL, NavarroIT. Patterns of transmission and sources of infection in outbreaks of human toxoplasmosis. Emerg Infect Dis, 2019; 25:2177–2182.
34.
PhanL, KaszaK, JalbrzikowskiJ, et al. Longitudinal study of new eye lesions in children with toxoplasmosis who were not treated during the first year of life. Am J Ophthalmol, 2008a;146. doi:10.1016/j.ajo.2008.04.03369.
35.
PhanL, KaszaK, JalbrzikowskiJ, et al. Longitudinal study of new eye lesions in treated congenital toxoplasmosis. Ophthalmology, 2008b;115. doi:10.1016/j.ophtha.2007.06.022
SaberiR, SharifM, SarviS, AghayanSA, HosseiniSA, AnvariD, Nayeri ChegeniT, HosseininejadZ, DaryaniA. Is Toxoplasma gondii playing a positive role in multiple sclerosis risk? A systematic review and meta-analysis. J Neuroimmunol, 2018; 322:57–62.
38.
ScallanE, HoekstraR, MahonB, JonesT, GriffinP. An assessment of the human health impact of seven leading foodborne pathogens in the United States using disability adjusted life years. Epidemiol Infect, 2015; 143:2795–2804.
39.
ScallanE, HoekstraRM, AnguloFJ, TauxeRV, WiddowsonMA, RoySL, JonesJL, GriffinPM. Foodborne illness acquired in the United States—major pathogens. Emerg Infect Dis, 2011; 17:7–15.
40.
SutterlandAL, FondG, KuinA, KoeterMWJ, LutterR, Van GoolT, YolkenR, SzokeA, LeboyerM, de HaanL. Beyond the association. Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction: Systematic review and meta-analysis. Acta Psychiatr Scand, 2015; 132:161–179.
41.
SYROCOT. Effectiveness of prenatal treatment for congenital toxoplasmosis: A metanalysis of individual patient's data. Lancet, 2007; 369:115–122.
42.
TriccoA, StrausS, MoherD. Preferred Reporting Items for Systematic Reviews and Meta-Analysis: Extension for Scoping Reviewers (PRISMA-ScR). Equator Network 2015. Available at: http://www.prisma-statement.org/Extensions/ScopingReviews, accessed May7, 2021.
43.
WallonM, KodjikianL, BinquetC, GarwegJ, FleuryJ, QuantinC, PeyronF. Long-term ocular prognosis in 327 children with congenital toxoplasmosis. Pediatrics, 2004; 113:1567–1572.
44.
ZhouZ, ZhouR, LiK, WeiW, ZhangZ, ZhuY, RongshengL. The association between Toxoplasma gondii infection and risk of Parkinson's disease: A systematic review and meta-analysis. Biomed Res Int, 2019; 2019:8186017.
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