Abstract
Experimental and clinical investigations over the past three decades have validated numerous hypotheses about tissue bonding of prostheses. Highly porous PTFE composite has been demonstrated to be an effective, inert, scaffold-like matrix onto which other materials can become physically bonded to achieve a tissue-specific result. Hydrophilic agents such as carbon and aluminum oxide stimulate ingrowth of fibroblasts that secrete collagen. These additives promote a robust and durable alloplast–soft tissue union composed mostly of collagen that is watertight. Bone-growth stimulants—such as hydroxyapatite—when added to highly porous PTFE stimulate tissue ingrowth and maturation that is more bone like.
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