Endoplasmic reticulum (ER) stress and oxidative stress (OS) are often related states in cells as part of normal physiology but more frequently manifested in the pathophysiology of many diseases, particularly diseases involving acute or chronic inflammation. In this study, we reviewed recent findings about the role of ER stress and OS in the pathogenesis of inflammatory diseases.
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References
1.
AdamJ, BolléeG, FougerayS, et al.Endoplasmic reticulum stress in UMOD-related kidney disease: A human pathologic study. Am J Kidney Dis, 2012; 59(1):117–121; doi: 10.1053/j.ajkd.2011.08.014.
2.
AhmedU, AnwarA, SavageRS, et al.Protein oxidation, nitration and glycation biomarkers for early-stage diagnosis of osteoarthritis of the knee and typing and progression of arthritic disease. Arthr Res Ther, 2016; 18(1):250; doi: 10.1186/s13075-016-1154-3.
3.
ApostolovaN, Gomez-SucerquiaLJ, AlegreF, et al.ER stress in human hepatic cells treated with Efavirenz: Mitochondria again. J Hepatol, 2013; 59(4):780–789; doi: 10.1016/j.jhep.2013.06.005.
4.
AvielloG, KnausUG. ROS in gastrointestinal inflammation: Rescue or Sabotage?. Br J Pharmacol, 2017; 174(12):1704–1718; doi: 10.1111/bph.13428.
5.
BalmusIM, CiobicaA, TrifanA, et al.The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models. Saudi J Gastroenterol, 2016; 22(1):3–17; doi: 10.4103/1319-3767.173753.
6.
BarreiroE, Salazar-DegraciaA, Sancho-MuñozA, et al.Endoplasmic reticulum stress and unfolded protein response profile in quadriceps of sarcopenic patients with respiratory diseases. J Cell Physiol, 2019; 234(7):11315–11329; doi: 10.1002/jcp.27789.
7.
BoothDM, MurphyJA, MukherjeeR, et al.Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells. Gastroenterology, 2011; 140(7):2116–2125; doi: 10.1053/j.gastro.2011.02.054.
8.
BoussabbehM, ProlaA, Ben SalemI, et al.Crocin and quercetin prevent PAT-induced apoptosis in mammalian cells: Involvement of ROS-mediated ER stress pathway. Environ Toxicol, 2016; 31(12):1851–1858; doi: 10.1002/tox.22185.
CaoSS, KaufmanRJ. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxid Redox Signal, 2014; 21(3):396–413; doi: 10.1089/ars.2014.5851.
11.
CaoSS, ZimmermannEM, ChuangBM, et al.The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology, 2013; 144(5):989.e6–1000.e6; doi: 10.1053/j.gastro.2013.01.023.
12.
ChenAC, BurrL, McGuckinMA. Oxidative and endoplasmic reticulum stress in respiratory disease. Clin Transl Immunol, 2018; 7(6):e1019; doi: 10.1002/cti2.1019.
13.
ChenX, Cubillos-RuizJR. Endoplasmic reticulum stress signals in the tumour and its microenvironment. Nat Rev Cancer, 2021; 21(2):71–88; doi: 10.1038/s41568-020-00312-2.
14.
ChenX, GuoX, GeQ, et al.ER stress activates the NLRP3 inflammasome: A novel mechanism of atherosclerosis. Oxidat Med Cell Longev, 2019; 2019:3462530; doi: 10.1155/2019/3462530.
15.
ChereshP, KimSJ, TulasiramS, et al.Oxidative stress and pulmonary fibrosis. Biochim Biophys Acta, 2013; 1832(7):1028–1040; doi: 10.1016/j.bbadis.2012.11.021.
16.
ChoiYM, LeeSY, KimBJ. Naturally occurring hepatitis B virus mutations leading to endoplasmic reticulum stress and their contribution to the progression of hepatocellular carcinoma. Int J Mol Sci, 2019; 20(3):597; doi: 10.3390/ijms20030597.
17.
CullinanSB, DiehlJA. Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway. Int J Biochem Cell Biol, 2006; 38(3):317–332; doi: 10.1016/j.biocel.2005.09.018.
18.
DasI, PngCW, OanceaI, et al.Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins. J Exp Med, 2013; 210(6):1201–1216; doi: 10.1084/jem.20121268.
19.
de Torre-MinguelaC, Mesa Del CastilloP, PelegrínP. The NLRP3 and pyrin inflammasomes: Implications in the pathophysiology of autoinflammatory diseases. Front Immunol, 2017; 8:43; doi: 10.3389/fimmu.2017.00043.
20.
DuvigneauJC, LuísA, GormanAM, et al.Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases. Cytokine, 2019; 124(C):154577; doi: 10.1016/j.cyto.2018.10.018.
21.
EngevikMA, HerrmannB, RuanW, et al.Bifidobacterium dentium-derived y-glutamylcysteine suppresses ER-mediated goblet cell stress and reduces TNBS-driven colonic inflammation. Gut Microb, 2021; 13(1):1–21; doi: 10.1080/19490976.2021.1902717.
22.
EriRD, AdamsRJ, TranTV, et al.An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity. Mucos Immunol, 2011; 4(3):354–364; doi: 10.1038/mi.2010.74.
23.
EsworthyRS, ArandaR, MartínMG, et al.Mice with combined disruption of Gpx1 and Gpx2 genes have colitis. Am J Physiol Gastrointest Liver Physiol, 2001; 281(3):G848–G855; doi: 10.1152/ajpgi.2001.281.3.G848.
24.
FarinatiF, CardinR, De MariaN, et al.Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis. J Hepatol, 1995; 22(4):449–456; doi: 10.1016/0168-8278(95)80108-1.
25.
GagliardiM, MonzaniR, ClementeN, et al.A Gut-ex-vivo system to study gut inflammation associated to inflammatory bowel disease (IBD). Biology, 2021; 10(7):605; doi: 10.3390/biology10070605.
26.
GalliganJJ, SmathersRL, ShearnCT, et al.Oxidative stress and the ER stress response in a murine model for early-stage alcoholic liver disease. J Toxicol, 2012; 2012(Pt.II):207594; doi: 10.1155/2012/207594.
27.
GhoshAK, GargSK, MauT, et al.Elevated endoplasmic reticulum stress response contributes to adipose tissue inflammation in aging. J Gerontol Ser A Biol Sci Med Sci, 2015; 70(11):1320–1329; doi: 10.1093/gerona/glu186.
28.
GlasJ, SeidererJ, CzamaraD, et al.PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites. PLoS One, 2012; 7(12):e52873; doi: 10.1371/journal.pone.0052873.
29.
GongT, WangX, YangY, et al.Plant lectins activate the NLRP3 inflammasome to promote inflammatory disorders. J Immunol (Baltimore, MD: 1950), 2017; 198(5):2082–2092; doi: 10.4049/jimmunol.1600145.
30.
GuoJ, HuH, ChenZ, et al.Cold exposure induces intestinal barrier damage and endoplasmic reticulum stress in the colon via the SIRT1/Nrf2 signaling pathway. Front Physiol, 2022; 13:822348; doi: 10.3389/fphys.2022.822348.
31.
GuthrieLN, AbiramanK, PlylerES, et al.Attenuation of PKR-like ER kinase (PERK) signaling selectively controls endoplasmic reticulum stress-induced inflammation without compromising immunological responses. J Biol Chem, 2016; 291(30):15830–15840; doi: 10.1074/jbc.M116.738021.
32.
HallidayM, RadfordH, SekineY, et al.Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. Cell Death Dis, 2015; 6(3):e1672; doi: 10.1038/cddis.2015.49.
33.
HasanainM, BhattacharjeeA, PandeyP, et al.α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway. Cell Death Dis, 2015; 6(8):e1860; doi: 10.1038/cddis.2015.219.
34.
HassanIH, ZhangMS, PowersLS, et al.Influenza A viral replication is blocked by inhibition of the inositol-requiring enzyme 1 (IRE1) stress pathway. J Biol Chem, 2012; 287(7):4679–4689; doi: 10.1074/jbc.M111.284695.
35.
HeC, QiuY, HanP, et al.ER stress regulating protein phosphatase 2A-B56γ, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes. Cell Death Dis, 2018; 9(7):762; doi: 10.1038/s41419-018-0787-3.
36.
HeazlewoodCK, CookMC, EriR, et al.Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med, 2008; 5(3):e54; doi: 10.1371/journal.pmed.0050054.
37.
HeliövaaraM, KnektP, AhoK, et al.Serum antioxidants and risk of rheumatoid arthritis. Ann Rheum Dis, 1994; 53(1):51–53; doi: 10.1136/ard.53.1.51.
38.
HenriksenEJ, Diamond-StanicMK, MarchionneEM. Oxidative stress and the etiology of insulin resistance and type 2 diabetes. Free Radic Biol Med, 2011; 51(5):993–999; doi: 10.1016/j.freeradbiomed.2010.12.005.
39.
HenrotinYE, BrucknerP, PujolJP. The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthr Cartil, 2003; 11(10):747–755; doi: 10.1016/s1063-s4584(03)00150-x.
40.
HitchonCA, El-GabalawyHS. Oxidation in rheumatoid arthritis. Arthr Res Ther, 2004; 6(6):265–278; doi: 10.1186/ar1447.
41.
HuP, HanZ, CouvillonAD, et al.Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol, 2006; 26(8):3071–3084; doi: 10.1128/mcb.26.8.3071-3084.2006.
42.
IvanovAV, BartoschB, SmirnovaOA, et al.HCV and oxidative stress in the liver. Viruses, 2013; 5(2):439–469; doi: 10.3390/v5020439.
43.
JaikumkaoK, PongchaidechaA, ChueakulaN, et al.Dapagliflozin, a sodium-glucose co-transporter-2 inhibitor, slows the progression of renal complications through the suppression of renal inflammation, endoplasmic reticulum stress and apoptosis in prediabetic rats. Diabetes Obes Metab, 2018; 20(11):2617–2626; doi: 10.1111/dom.13441.
44.
JainT, NikolopoulouEA, XuQ, et al.Hypoxia inducible factor as a therapeutic target for atherosclerosis. Pharmacol Ther, 2018; 183:22–33; doi: 10.1016/j.pharmthera.2017.09.003.
45.
KaserA, AdolphTE, BlumbergRS. The unfolded protein response and gastrointestinal disease. Semin Immunopathol, 2013; 35(3):307–319; doi: 10.1007/s00281-013-0377-5.
46.
KaserA, LeeAH, FrankeA, et al.XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell, 2008; 134(5):743–756; doi: 10.1016/j.cell.2008.07.021.
47.
KattoorAJ, PothineniNVK, PalagiriD, et al.Oxidative stress in atherosclerosis. Curr Atheroscler Rep, 2017; 19(11):42; doi: 10.1007/s11883-017-0678-6.
48.
KePY, ChenSS. Hepatitis C virus and cellular stress response: Implications to molecular pathogenesis of liver diseases. Viruses, 2012; 4(10):2251–2290; doi: 10.3390/v4102251.
49.
KhorTO, HuangMT, KwonKH, et al.Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer Res, 2006; 66(24):11580–11584; doi: 10.1158/0008-5472.Can-06-3562.
50.
KimHJ, JeongJS, KimSR, et al.Inhibition of endoplasmic reticulum stress alleviates lipopolysaccharide-induced lung inflammation through modulation of NF-κB/HIF-1α signaling pathway. Sci Rep, 2013; 3(1):1142; doi: 10.1038/srep01142.
51.
KomuraT, SakaiY, HondaM, et al.ER stress induced impaired TLR signaling and macrophage differentiation of human monocytes. Cell Immunol, 2013; 282(1):44–52; doi: 10.1016/j.cellimm.2013.04.006.
52.
KudoY, SugimotoM, AriasE, et al.PKCλ/ι loss induces autophagy, oxidative phosphorylation, and NRF2 to promote liver cancer progression. Cancer Cell, 2020; 38(2):247.e11–262.e11; doi: 10.1016/j.ccell.2020.05.018.
53.
LaudisiF, Di FuscoD, DinalloV, et al.The food additive maltodextrin promotes endoplasmic reticulum stress-driven mucus depletion and exacerbates intestinal inflammation. Cell Mol Gastroenterol Hepatol, 2019; 7(2):457–473; doi: 10.1016/j.jcmgh.2018.09.002.
54.
LebeaupinC, ProicsE, de BievilleCH, et al.ER stress induces NLRP3 inflammasome activation and hepatocyte death. Cell Death Dis, 2015; 6(9):e1879; doi: 10.1038/cddis.2015.248.
55.
LeeIT, YangCM. Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases. Biochem Pharmacol, 2012; 84(5):581–590; doi: 10.1016/j.bcp.2012.05.005.
56.
LeeWS, JeongJH, LeeEG, et al.Tacrolimus regulates endoplasmic reticulum stress-mediated osteoclastogenesis and inflammation: In vitro and collagen-induced arthritis mouse model. Cell Biol Int, 2018; 42(4):393–402; doi: 10.1002/cbin.10861.
57.
LernerAG, UptonJP, PraveenPV, et al.IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab, 2012; 16(2):250–264; doi: 10.1016/j.cmet.2012.07.007.
58.
LiongS, LappasM. Endoplasmic reticulum stress regulates inflammation and insulin resistance in skeletal muscle from pregnant women. Mol Cell Endocrinol, 2016; 425:11–25; doi: 10.1016/j.mce.2016.02.016.
59.
LiuZ, ZhangHM, YuanJ, et al.The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway. Cell Microbiol, 2012; 14(1):133–146; doi: 10.1111/j.1462-5822.2011.01708.x.
60.
LorzC, JustoP, SanzA, et al.Paracetamol-induced renal tubular injury: A role for ER stress. J Am Soc Nephrol, 2004; 15(2):380–389; doi: 10.1097/01.asn.0000111289.91206.b0.
61.
LugeaA, TischlerD, NguyenJ, et al.Adaptive unfolded protein response attenuates alcohol-induced pancreatic damage. Gastroenterology, 2011; 140(3):987–997; doi: 10.1053/j.gastro.2010.11.038.
62.
MaamounH, BenameurT, PintusG, et al.Crosstalk between oxidative stress and endoplasmic reticulum (ER) stress in endothelial dysfunction and aberrant angiogenesis associated with diabetes: A focus on the protective roles of heme oxygenase (HO)-1. Front Physiol, 2019; 10:70; doi: 10.3389/fphys.2019.00070.
63.
MargittaiÉ, LöwP, StillerI, et al.Production of H2O2 in the endoplasmic reticulum promotes in vivo disulfide bond formation. Antioxid Redox Signal, 2012; 16(10):1088–1099; doi: 10.1089/ars.2011.4221.
64.
MarschE, SluimerJC, DaemenMJ. Hypoxia in atherosclerosis and inflammation. Curr Opin Lipidol, 2013; 24(5):393–400; doi: 10.1097/MOL.0b013e32836484a4.
65.
MateenS, MoinS, KhanAQ, et al.Increased reactive oxygen species formation and oxidative stress in rheumatoid arthritis. PLoS One, 2016; 11(4):e0152925; doi: 10.1371/journal.pone.0152925.
66.
McGuckinMA, EriRD, DasI, et al.Intestinal secretory cell ER stress and inflammation. Biochem Soc Trans, 2011; 39(4):1081–1085; doi: 10.1042/bst0391081.
67.
MearesGP, LiuY, RajbhandariR, et al.PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation. Mol Cell Biol, 2014; 34(20):3911–3925; doi: 10.1128/mcb.00980-14.
68.
MennerichD, KellokumpuS, KietzmannT. Hypoxia and reactive oxygen species as modulators of endoplasmic reticulum and golgi homeostasis. Antioxid Redox Signal, 2019; 30(1):113–137; doi: 10.1089/ars.2018.7523.
69.
MenuP, MayorA, ZhouR, et al.ER stress activates the NLRP3 inflammasome via an UPR-independent pathway. Cell Death Dis, 2012; 3(1):e261; doi: 10.1038/cddis.2011.132.
70.
Mohseni Salehi MonfaredSS, VahidiH, AbdolghaffariAH, et al.Antioxidant therapy in the management of acute, chronic and post-ERCP pancreatitis: A systematic review. World J Gastroenterol, 2009; 15(36):4481–4490; doi: 10.3748/wjg.15.4481.
71.
MorenoJA, HallidayM, MolloyC, et al.Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice. Sci Transl Med, 2013; 5(206):206ra138; doi: 10.1126/scitranslmed.3006767.
72.
NaidooN. The endoplasmic reticulum stress response and aging. Rev Neurosci, 2009; 20(1):23–37; doi: 10.1515/revneuro.2009.20.1.23.
73.
NakayamaT, KurobeH, SugasawaN, et al.Role of macrophage-derived hypoxia-inducible factor (HIF)-1α as a mediator of vascular remodelling. Cardiovasc Res, 2013; 99(4):705–715; doi: 10.1093/cvr/cvt146.
74.
NishimotoS, KoikeS, InoueN, et al.Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification mechanism. Biochem Biophys Res Commun, 2017; 483(2):874–879; doi: 10.1016/j.bbrc.2017.01.024.
75.
OakesSA, PapaFR. The role of endoplasmic reticulum stress in human pathology. Ann Rev Pathol, 2015; 10(1):173–194; doi: 10.1146/annurev-pathol-012513-104649.
76.
Osada-OkaM, IkedaT, AkibaS, et al.Hypoxia stimulates the autocrine regulation of migration of vascular smooth muscle cells via HIF-1alpha-dependent expression of thrombospondin-1. J Cell Biochem, 2008; 104(5):1918–1926; doi: 10.1002/jcb.21759.
77.
ParathathS, YangY, MickS, et al.Hypoxia in murine atherosclerotic plaques and its adverse effects on macrophages. Trends Cardiovasc Med, 2013; 23(3):80–84; doi: 10.1016/j.tcm.2012.09.004.
78.
PereraAP, KundeD, EriR. NLRP3 inhibitors as potential therapeutic agents for treatment of inflammatory bowel disease. Curr Pharm Des, 2017; 23(16):2321–2327; doi: 10.2174/1381612823666170201162414.
79.
PeyssonnauxC, Cejudo-MartinP, DoedensA, et al.Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J Immunol (Baltimore, MD: 1950), 2007; 178(12):7516–7519; doi: 10.4049/jimmunol.178.12.7516.
80.
PhullAR, NasirB, HaqIU, et al.Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis. Chem Biol Interact, 2018; 281:121–136; doi: 10.1016/j.cbi.2017.12.024.
81.
QiuQ, ZhengZ, ChangL, et al.Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. EMBO J, 2013; 32(18):2477–2490; doi: 10.1038/emboj.2013.183.
82.
RalstonJC, LyonsCL, KennedyEB, et al.Fatty acids and NLRP3 inflammasome-mediated inflammation in metabolic tissues. Ann Rev Nutr, 2017; 37:77–102; doi: 10.1146/annurev-nutr-071816-064836.
83.
ReesWD, StahlM, JacobsonK, et al.Enteroids derived from inflammatory bowel disease patients display dysregulated endoplasmic reticulum stress pathways, leading to differential inflammatory responses and dendritic cell maturation. J Crohns Colitis, 2020; 14(7):948–961; doi: 10.1093/ecco-jcc/jjz194.
84.
RenJX, LiC, YanXL, et al.Crosstalk between oxidative stress and ferroptosis/oxytosis in ischemic stroke: possible targets and molecular mechanisms. Oxidat Med Cell Longev, 2021; 2021:6643382; doi: 10.1155/2021/6643382.
85.
RiazTA, JunjappaRP, HandigundM, et al.Role of endoplasmic reticulum stress sensor IRE1a in cellular physiology, calcium, ROS signaling, and metaflammation. Cells, 2020; 9(5):1160; doi: 10.3390/cells9051160.
86.
Ríos-OcampoWA, DaemenT, Buist-HomanM, et al.Hepatitis C virus core or NS3/4A protein expression preconditions hepatocytes against oxidative stress and endoplasmic reticulum stress. Redox Rep Commun Free Radic Rese, 2019; 24(1):17–26; doi: 10.1080/13510002.2019.1596431.
SateeshJ, BhardwajP, SinghN, et al.Effect of antioxidant therapy on hospital stay and complications in patients with early acute pancreatitis: A randomised controlled trial. Trop Gastroenterol, 2009; 30(4):201–206.
90.
ŚciskalskaM, Śliwińska-MossońM, PodawaczM, et al.Mechanisms of interaction of the N-acetyl-p-aminophenol metabolites in terms of nephrotoxicity. Drug Chem Toxicol, 2015; 38(2):121–125; doi: 10.3109/01480545.2014.928722.
91.
ShenderovK, RiteauN, YipR, et al.Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway. J Immunol (Baltimore, MD: 1950), 2014; 192(5):2029–2033; doi: 10.4049/jimmunol.1302549.
92.
SrinivasUS, TanBWQ, VellayappanBA, et al.ROS and the DNA damage response in cancer. Redox Biol, 2019; 25(C):101084; doi: 10.1016/j.redox.2018.101084.
93.
TabasI, RonD. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol, 2011; 13(3):184–190; doi: 10.1038/ncb0311-184.
94.
TangN, WangL, EskoJ, et al.Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell, 2004; 6(5):485–495; doi: 10.1016/j.ccr.2004.09.026.
95.
TawiahA, CornickS, MoreauF, et al.High MUC2 mucin expression and misfolding induce cellular stress, reactive oxygen production, and apoptosis in goblet cells. Am J Pathol, 2018; 188(6):1354–1373; doi: 10.1016/j.ajpath.2018.02.007.
96.
ten FreyhausH, DagnellM, LeuchsM, et al.Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases. Am J Respir Crit Care Med, 2011; 183(8):1092–1102; doi: 10.1164/rccm.200911-201663OC.
97.
TsaiTH, HuangCJ, WuWH, et al.Antioxidant, cell-protective, and anti-melanogenic activities of leaf extracts from wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) cultivars. Bot Stud, 2014; 55(1):78; doi: 10.1186/s40529-014-0078-y.
98.
ValgimigliM, ValgimigliL, TrerèD, et al.Oxidative stress EPR measurement in human liver by radical-probe technique. Correlation with etiology, histology and cell proliferation. Free Radic Res, 2002; 36(9):939–948; doi: 10.1080/107156021000006653.
99.
Van der WallH, PalmerA. On the AJR viewbox. Monomelic spread of metastatic disease due to proximal deep venous thrombosis. Am J Roentgenol, 2006; 186(6):1797–1799; doi: 10.2214/ajr.04.0930.
100.
VictorP, SaradaD, RamkumarKM. Crosstalk between endoplasmic reticulum stress and oxidative stress: Focus on protein disulfide isomerase and endoplasmic reticulum oxidase 1. Eur J Pharmacol, 2021; 892:173749; doi: 10.1016/j.ejphar.2020.173749.
101.
WangQL, YangL, PengY, et al.Ginsenoside Rg1 regulates SIRT1 to ameliorate sepsis-induced lung inflammation and injury via inhibiting endoplasmic reticulum stress and inflammation. Mediat Inflamm, 2019a;2019:6453296; doi: 10.1155/2019/6453296.
102.
WangY, HuH, YinJ, et al.TLR4 participates in sympathetic hyperactivity Post-MI in the PVN by regulating NF-κB pathway and ROS production. Redox Biol, 2019b;24:101186; doi: 10.1016/j.redox.2019.101186.
103.
WendlandBE, AghdassiE, TamC, et al.Lipid peroxidation and plasma antioxidant micronutrients in Crohn disease. Am J Clin Nutr, 2001; 74(2):259–264; doi: 10.1093/ajcn/74.2.259.
104.
WiegmanCH, LiF, RyffelB, et al.Oxidative stress in ozone-induced chronic lung inflammation and emphysema: A facet of chronic obstructive pulmonary disease. Front Immunol, 2020; 11:1957; doi: 10.3389/fimmu.2020.01957.
105.
XuM, TaoJ, YangY, et al.Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis. Cell Death Dis, 2020; 11(2):86; doi: 10.1038/s41419-020-2299-1.
106.
YangH, CuiJ, ShiJ, et al.Endoplasmic reticulum stress participates in inflammation-accelerated, lipid-mediated injury of human glomerular mesangial cells. Nephrology (Carlton, Vic.), 2017; 22(3):234–242; doi: 10.1111/nep.12748.
107.
ZepedaAB, PessoaAJr., CastilloRL, et al.Cellular and molecular mechanisms in the hypoxic tissue: Role of HIF-1 and ROS. Cell Biochem Funct, 2013; 31(6):451–459; doi: 10.1002/cbf.2985.
108.
ZhaX, YueY, DongN, et al.Endoplasmic reticulum stress aggravates viral myocarditis by raising inflammation through the IRE1-associated NF-κB pathway. Canadian J Cardiol, 2015; 31(8):1032–1040; doi: 10.1016/j.cjca.2015.03.003.
109.
ZhangHM, YeX, SuY, et al.Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1. J Virol, 2010; 84(17):8446–8459; doi: 10.1128/jvi.01416-09.
110.
ZhangJ, WangX, VikashV, et al.ROS and ROS-mediated cellular signaling. Oxidat Med Cell Longev, 2016; 2016:4350965; doi: 10.1155/2016/4350965.
111.
ZhuH, LiYR. Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: Updated experimental and clinical evidence. Exp Biol Med (Maywood, NJ), 2012; 237(5):474–480; doi: 10.1258/ebm.2011.011358.
