Antiviral innate immune responses and apoptosis are the two major factors limiting viral infections. Successful viral infection requires the virus to take advantage of the cellular machinery to bypass cellular defenses. Accumulated evidences show that autophagy plays a crucial role in cell-to-virus interaction. Here, we focus on how viruses subvert mitophagy to favor viral replication by mitigating innate immune responses and apoptotic signaling.
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References
1.
AokiY., KankiT., HirotaY., KuriharaY., SaigusaT., UchiumiT., et al. (2011). Phosphorylation of Serine 114 on Atg32 mediates mitophagy. Mol Biol Cell, 22, 3206–3217.
2.
BlechaczB., SplinterP.L., GreinerS., MyersR., PengK.W., FederspielM.J., et al. (2006). Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma. Hepatology, 44, 1465–1477.
3.
CastanierC., GarcinD., VazquezA., and ArnoultD. (2010). Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway. EMBO Rep, 11, 133–138.
4.
CrotzerV.L., and BlumJ.S. (2010). Autophagy and adaptive immunity. Immunology, 131, 9–17.
5.
DereticV. (2012). Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors. Curr Opin Immunol, 24, 21–31.
6.
DereticV., and LevineB. (2009). Autophagy, immunity, and microbial adaptations. Cell Host Microbe, 5, 527–549.
7.
Djavaheri-MergnyM., MaiuriM.C., and KroemerG. (2010). Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1. Oncogene, 29, 1717–1719.
8.
DuranA., LinaresJ.F., GalvezA.S., WikenheiserK., FloresJ.M., Diaz-MecoM.T., et al. (2008). The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. Cancer Cell, 13, 343–354.
9.
EstaquierJ., ValletteF., VayssiereJ.L., and MignotteB. (2012). The mitochondrial pathways of apoptosis. Adv Exp Med Biol, 942, 157–183.
10.
GannageM., DormannD., AlbrechtR., DengjelJ., TorossiT., RamerP.C., et al. (2009). Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes. Cell Host Microbe, 6, 367–380.
11.
GeislerS., HolmstromK.M., SkujatD., FieselF.C., RothfussO.C., KahleP.J., et al. (2010). PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol, 12, 119–131.
12.
GiansantiV., TorrigliaA., and ScovassiA.I. (2011). Conversation between apoptosis and autophagy: “Is it your turn or mine?”. Apoptosis, 16, 321–333.
13.
GregoireI.P., RichettaC., Meyniel-SchicklinL., BorelS., PradezynskiF., DiazO., et al. (2011). IRGM is a common target of RNA viruses that subvert the autophagy network. PLoS Pathog 7,e1002422.
14.
HaywardA.P., and Dinesh-KumarS.P. (2010). Special delivery for MHC II via autophagy. Immunity, 32, 587–590.
15.
HeatonN.S., and RandallG. (2011). Dengue virus and autophagy. Viruses, 3, 1332–1341.
16.
JinS.M., and YouleR.J. (2012). PINK1- and Parkin-mediated mitophagy at a glance. J Cell Sci, 125, 795–799.
17.
JoubertP.E., WernekeS.W., de la CalleC., Guivel-BenhassineF., GiodiniA., PedutoL., et al. (2012). Chikungunya virus-induced autophagy delays caspase-dependent cell death. J Exp Med, 209, 1029–1047.
18.
KimI., Rodriguez-EnriquezS., and LemastersJ.J. (2007). Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys, 462, 245–253.
19.
KimS.J., KhanM., QuanJ., TillA., SubramaniS., and SiddiquiA. (2013a). Hepatitis B virus disrupts mitochondrial dynamics: induces fission and mitophagy to attenuate apoptosis. PLoS Pathog 9,e1003722.
20.
KimS.J., SyedG.H., and SiddiquiA. (2013b). Hepatitis C virus induces the mitochondrial translocation of Parkin and subsequent mitophagy. PLoS Pathog 9,e1003285.
21.
KimS.J., SyedG.H., KhanM., ChiuW.W., SohailM.A., GishR.G., et al. (2014). Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence. Proc Natl Acad Sci U S A, 111, 6413–6418.
22.
KnodlerL.A., and CelliJ. (2011). Eating the strangers within: host control of intracellular bacteria via xenophagy. Cell Microbiol, 13, 1319–1327.
23.
KudchodkarS.B., and LevineB. (2009). Viruses and autophagy. Rev Med Virol, 19, 359–378.
24.
KyeiG.B., DinkinsC., DavisA.S., RobertsE., SinghS.B., DongC., et al. (2009) Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol, 186, 255–268.
25.
LartigueL., and FaustinB. (2013). Mitochondria: metabolic regulators of innate immune responses to pathogens and cell stress. Int J Biochem Cell Biol, 45, 2052–2056.
26.
LevineB. (2005). Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell, 120, 159–162.
27.
LiW., YangQ., and MaoZ. (2011). Chaperone-mediated autophagy: machinery, regulation and biological consequences. Cell Mol Life Sci, 68, 749–763.
28.
LupferC., ThomasP.G., AnandP.K., VogelP., MilastaS., MartinezJ., et al. (2013). Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol, 14, 480–488.
29.
LussignolM., QuevalC., Bernet-CamardM.F., Cotte-LaffitteJ., BeauI., CodognoP., et al. (2013). The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR. J Virol, 87, 859–871.
30.
MaierH.J., and BrittonP. (2012). Involvement of autophagy in coronavirus replication. Viruses, 4, 3440–3451.
31.
MaiuriM.C., ZalckvarE., KimchiA., and KroemerG. (2007). Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol, 8, 741–752.
32.
MathewR., KarpC.M., BeaudoinB., VuongN., ChenG., ChenH.Y., et al. (2009). Autophagy suppresses tumorigenesis through elimination of p62. Cell, 137, 1062–1075.
33.
McLeanJ.E., WudzinskaA., DatanE., QuaglinoD., and ZakeriZ. (2011). Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication. J Biol Chem, 286, 22147–22159.
34.
MeiffrenG., JoubertP.E., GregoireI.P., CodognoP., Rabourdin-CombeC., and FaureM. (2010). Pathogen recognition by the cell surface receptor CD46 induces autophagy. Autophagy, 6, 299–300.
35.
MsaouelP., DispenzieriA., and GalanisE. (2009). Clinical testing of engineered oncolytic measles virus strains in the treatment of cancer: an overview. Curr Opin Mol Ther, 11, 43–53.
36.
RichettaC., GregoireI.P., VerlhacP., AzocarO., BaguetJ., FlacherM., et al. (2013). Sustained autophagy contributes to measles virus infectivity. PLoS Pathog 9,e1003599.
37.
Rodriguez-RochaH., Gomez-GutierrezJ.G., Garcia-GarciaA., RaoX.M., ChenL., McMastersK.M., et al. (2011). Adenoviruses induce autophagy to promote virus replication and oncolysis. Virology, 416, 9–15.
38.
RossmanJ.S., and LambR.A. (2009). Autophagy, apoptosis, and the influenza virus M2 protein. Cell Host Microbe, 6, 299–300.
39.
RussellS.J., and PengK.W. (2009). Measles virus for cancer therapy. Curr Top Microbiol Immunol, 330, 213–241.
ShrivastavaS., RaychoudhuriA., SteeleR., RayR., and RayR.B. (2011). Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes. Hepatology, 53, 406–414.
42.
SinghS.B., OrnatowskiW., VergneI., NaylorJ., DelgadoM., RobertsE., et al. (2010). Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat Cell Biol, 12, 1154–1165.
43.
TaylorM.P., and KirkegaardK. (2007). Modification of cellular autophagy protein LC3 by poliovirus. J Virol, 81, 12543–12553.
44.
ThompsonH.G., HarrisJ.W., WoldB.J., LinF., and BrodyJ.P. (2003). p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells. Oncogene, 22, 2322–2333.
45.
WestA.P., ShadelG.S., and GhoshS. (2011). Mitochondria in innate immune responses. Nat Rev Immunol, 11, 389–402.
46.
WildP., FarhanH., McEwanD.G., WagnerS., RogovV.V., BradyN.R., et al. (2011). Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science, 333, 228–233.
XiaM., MengG., JiangA., ChenA., DahlhausM., GonzalezP., et al. (2014b). Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus. Oncotarget, 5, 3907–3918.
49.
YangY., XingD., ZhouF., and ChenQ. (2010). Mitochondrial autophagy protects against heat shock-induced apoptosis through reducing cytosolic cytochrome c release and downstream caspase-3 activation. Biochem Biophys Res Commun, 395, 190–195.
50.
ZhangJ., and NeyPA. (2009). Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ, 16, 939–946.
51.
ZhuY., MassenS., TerenzioM., LangV., Chen-LindnerS., EilsR., et al. (2013). Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem, 288, 1099–1113.
