Restricted accessResearch articleFirst published online 2011-11
Comparison of mRNA Expression Patterns of Class B Scavenger Receptors in BV2 Microglia upon Exposure to Amyloidogenic Fragments of Beta-Amyloid and Prion Proteins
The inflammatory responses in Alzheimer's disease and prion diseases are dominated by microglia activation. Scavenger receptors have been recently related to the innate immune activation of microglia initiated by endogenous ligands. In this study, we investigated mRNA expression patterns of B class scavenger receptors CD36 and scavenger receptor B1 (SR-B1) in BV2 microglia upon exposure to amyloid fibril Aβ1–42 and PrP106–126, respectively. CD36 and SR-B1 showed similar mRNA expression patterns following each treatment. PrP106–126 induced a rapid increase of CD36 and SR-B1 mRNA levels in the treated microglia, whereas Aβ1–42 induced a delayed but persistent increase in the mRNA expression of CD36 and SR-B1. These results suggest a possible involvement of CD36 and SR-B1 in microglial interaction with amyloidogenic fragments of beta-amyloid and prion proteins.
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