Genomic Organization and Chromosome Localization to Band 19p13.3 of the Human AES Gene: Gene Product Exhibits Strong Similarity to the N-Terminal Domain of Drosophila Enhancer of Split Groucho Protein

Abstract

The human Amino Enhancer of Split (AES) gene encodes a protein of 197 amino acids exhibiting strong similarity to the N-terminal domain of Drosophila Enhancer of Split Groucho (ESG) protein. The nucleotide sequence of approximately 12 kb from the human AES gene was determined, and its protein-encoding sequence was shown to be interrupted by six introns. The human AES gene was further localized by fluorescence in situ hybridization to chromosome band 19p13.3 near the transcription factor 3 (TCF3) gene.