Abstract
Background:
Relatives with single positive islet autoantibodies have a much lower risk of progression to diabetes than those with multiple autoantibodies.
Materials and Methods:
TrialNet subjects positive for single autoantibody to insulin (mIAA) (
Results:
After a mean follow-up of 5.3 years, 20 subjects developed type 1 diabetes. Among either single GADA or single mIAA subjects, those who were positive in the ECL assay showed higher affinity at the initial visit, and affinity results stayed consistent over time. No converting events from low to high or high to low affinity were seen over time.
Conclusions:
Confirmed positivity for ECL is associated with high affinity and can help staging of risk for type 1 diabetes in single autoantibody-positive subjects.
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Supplementary Material
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