Daily Glucose Profiles in Japanese People with Normal Glucose Tolerance as Assessed by Continuous Glucose Monitoring

Abstract

Background:

Little information is available regarding glucose fluctuations in postprandial states and during the oral glucose tolerance test (OGTT) in Japanese people with normal glucose tolerance (NGT).

Methods:

Glucose profiles of 27 Japanese people were measured for 4 days by using continuous glucose monitoring. A 75-g OGTT was conducted on the second day, and 24 subjects diagnosed with NGT by a 75-g OGTT were enrolled. The subjects were monitored for their postprandial glucose profile in their ordinary daily life on the third day.

Results:

The results of our study have shown that the median time (interquartile range) to maximum glucose levels in OGTT was 38 (25–49) min after glucose load and that the median time to maximum glucose levels after breakfast, lunch, and dinner was 40 (31–75), 50 (30–70), and 45 (36–50) min, respectively. The median increase in glucose during OGTT was 45 (35–66) mg/dL, and that after breakfast, lunch and dinner was 21 (12–32), 37 (27–48), and 44 (25–63) mg/dL, respectively. Those with a higher insulinogenic index reached their maximum glucose levels in a shorter time (r = −0.46, P = 0.025) and had smaller glucose increments during OGTT (r = −0.49, P = 0.014).

Conclusions:

This study is the first report to document the glucose profile of Asian people with NGT.