Patient Acceptance and Issues of Education of Two Durable Insulin Pen Devices

Abstract

Background:

Insulin pen devices offer patients a more convenient, accurate, and discreet mode of insulin delivery than traditional syringes and vials. This open-label, randomized, comparative crossover study assessed patient preference for two reusable pens: NovoPen^® 4 (Novo Nordisk A/S, Copenhagen, Denmark) and OptiClik^® (Sanofi-Aventis, Bridgewater NJ).

Methods:

Thirty-five diabetes patients with no previous experience of pen devices (mean age 56.7 years; range 17–80 years; 57% male) used both pens to deliver a 10 unit saline dose into an injection cushion. Half received guidance according to official instruction manuals, and half were given no instructions. Learning times were also measured. Participants completed a detailed questionnaire to determine their preferences.

Results:

Overall, 32 of 35 participants preferred NovoPen 4 compared with two of 35 for OptiClik (91.4% vs. 5.7% respectively, P < 0.001), and one had no preference. NovoPen 4 was significantly favored over OptiClik in almost all questionnaire criteria, including safety (P < 0.001), size of pen (P < 0.001), appearance (P < 0.001), and ease of use (P < 0.001). The majority of patients were able to use NovoPen 4 without guidance (94.4%) compared with just over half for for OptiClik (55.6%, P < 0.01). Learning time was also significantly faster for NovoPen 4 (62.6 s) than for OptiClik (95.8 s) (P < 0.05).

Conclusions:

Patients learned how to use both pens quickly (under 2 min), but NovoPen 4 was preferred by participants over OptiClik. Patient acceptance of a pen device may support insulin initiation, particularly in type 2 diabetes.