Abstracts: Background: Atopic Dermatitis® (AD) is a chronic dermatological condition that affects both patients and their caregivers.
Aims: To summarize evidence on the impact of AD on the quality of life (QoL) of caregiver.
Methods: Observational studies were searched for in Medline, Embase, Cochrane Library, SCOPUS, and CINAHL databases up till March 1, 2023.
Results: Seventy studies with a total of 33,291 study participants were identified. The Dermatitis® Family Index (DFI) questionnaire featured in 29 studies and was chosen for further meta-analysis. The pooled DFI for all studies was 9.35 (95% confidence interval [CI] 6.94–11.76). For individual components, the highest component scores were for 1.24 for expenditure (95% CI 0.80–1.69), followed by 1.14 for emotions (95% CI 0.77–1.50), as well as sleep 1.12 (95% CI 0.71–1.54) and exhaustion 1.12 (95% CI 0.76–1.48). Meta-analysis on the effect of patient QoL on family QoL was conducted on 15 studies, with a pooled Spearman's rank coefficient using Infants' Dermatitis® Quality of Life Index (IDQoL) was 0.632 (95% CI 0.558–0.707), whereas that using Children's Dermatology Life Quality Index (CDLQI) was 0.624 (95% CI 0.507–0.741). For the 17 studies correlating AD severity with family QoL, a pooled Spearman's rank coefficient of 0.425 (95% CI 0.330–0.521) was obtained.
Conclusions: AD is associated with significant negative impacts on caregiver QoL, particularly in family finance, caregiver burnout, and sleep impairment. This was consistently affected by AD severity and patient QoL in all studies examining this association.
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