BarrangouR, FremauxC, DeveauH, et al.CRISPR provides acquired resistance against viruses in prokaryotes. Science, 2007; 315:1709–1712. DOI: 10.1126/science.1138140.
2.
WiedenheftB, ZhouK, JinekM, et al.Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense. Structure, 2009; 17:904–912. DOI: 10.1016/j.str.2009.03.019.
3.
DeltchevaE, ChylinskiK, SharmaCM, et al.CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III. Nature, 2011; 471:602–607. DOI: 10.1038/nature09886.
4.
JínekM, ChylinskiK, FonfaraI, et al.A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science, 2012; 337:816–821. DOI: 10.1126/science.1225829.
5.
GasiunasG, BarrangouR, HorvathP, et al.Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. Proc Natl Acad Sci U S A, 2012; 109:E2579–E2586. DOI: 10.1073/pnas.1208507109.
6.
JínekM, EastA, ChengA, et al.RNA-programmed genome editing in human cells. eLife, 2013; 2:e00471. DOI: 10.7554/eLife.00471.
