ReesHA, LiuDR. Base editing: precision chemistry on the genome and transcriptome of living cells. Nat Rev Genet. 2018; 19:770–788. DOI: 10.1038/s41576-018-0059-1.
2.
ZuoE, SunY, WeiW, et al.Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos. Science. 2019 Feb 28. DOI: 10.1126/science.aav9973.
3.
JinS, ZongY, GaoQ, et al.Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice. Science. 2019 Feb 28. DOI: 10.1126/science.aaw7166.
4.
KomorAC, KimYB, PackerMS, et al.Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature. 2016; 533:420–424. DOI: 10.1038/nature17946.
5.
HarrisRS, Petersen-MahrtSK, NeubergerMS. RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. Mol Cell. 2002; 10:1247–1253.
6.
RadanyEH, DornfeldKJ, SandersonRJ, et al.Increased spontaneous mutation frequency in human cells expressing the phage PBS2-encoded inhibitor of uracil-DNA glycosylase. Mutat Res. 2000; 461:41–58.
7.
NishidaK, ArazoeT, YachieN, et al.Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems. Science. 2016; 353. DOI: 1–0.1126/science.aaf8729.
8.
GehrkeJM, CervantesO, ClementMK, et al.An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities. Nat Biotechnol. 2018; 36:977–982. DOI: 10.1038/nbt.4199.
9.
WangX, LiJ, WangY, et al.Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion. Nat Biotechnol. 2018; 36:946–949. DOI: 10.1038/nbt.4198.
10.
GaudelliNM, KomorAC, ReesHA, et al.Programmable base editing of A*T to G*C in genomic DNA without DNA cleavage. Nature. 2017; 551:464–471. DOI: 10.1038/nature24644.
11.
KimYB, KomorAC, LevyJM, et al.Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions. Nat Biotechnol. 2017; 35:371–376. DOI: 10.1038/nbt.3803.
12.
HuaK, TaoX, ZhuJK. Expanding the base editing scope in rice by using Cas9 variants. Plant Biotechnol J. 2019; 17:499–504. DOI: 10.1111/pbi.12993.
13.
YangL, ZhangX, WangL, et al.Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants. Protein Cell. 2018; 9:814–819. DOI: 10.1007/s13238-018-0568-x.
14.
ReesHA, KomorAC, YehWH, et al.Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery. Nat Commun. 2017; 8:1579–0. DOI: 10.1038/ncomms15790.
15.
RyuSM, KooT, KimK, et al.Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy. Nat Biotechnol. 2018; 36:536–539. DOI: 10.1038/nbt.4148.
16.
LiuZ, LuZ, YangG, et al.Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing. Nat Commun. 2018; 9:233–8. DOI: 10.1038/s41467-018-04768-7.
17.
MadisenL, ZwingmanTA, SunkinSM, et al.A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci. 2010; 13:133–140. DOI: 10.1038/nn.2467.