Abstract
The influence of Nd:YAG laser hyperthermia (45°C for 20 min) on local tumor recurrence followed by CO2 laser or scalpel excision was studied on 150 F344 female rats that were implanted with R3230AC mammary tumor in the mammary ridge. The development of local tumor recurrence was observed for 39 days postoperatively. All groups undergoing CO2 laser excision showed a significant reduction in local tumor recurrence (p < 0.05) compared with the scalpel technique. Animals that underwent CO2 laser excision and wound sterilization 48 h following laser hyperthermia demonstrated the lowest recurrence when compared with scalpel excision (p < 0.01). These results indicate that the local thermal effect achieved by laser hyperthermia or laser sterilization plays an important role in the reduction of local tumor recurrence and augments complete local tumor resection.
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