The scope of this article is not to provide an exhaustive review of nuclear transfer research, because many authoritative reviews exist on the biological issues related to somatic and embryonic cell nuclear transfer. We shall instead provide an overview on the work done specifically on sheep and the value of this work on the greater nuclear transfer landscape.
Get full access to this article
View all access options for this article.
References
1.
BriggsR., KingT.J.1952. Transplantation of living nuclei from blastula cells into enucleated frog eggs. Proc. Natl. Acad. Sci. USA., 38:455–463.
2.
BowlesE.J., LeeJ.H., AlberioR., LloydR.E, StekelD., CampbellK.H.St., JohnJ.C.2007. Contrasting effects of in vitro fertilization and nuclear transfer on the expression of mtDNA replication factors. Genetics, 176:1511–1526.
3.
CampbellK.H.S., LoiP., CappaiP., WilmutI.1994. Improved development to blastocyst of ovine nuclear transfer embryos reconstructed during the presumptive S-phase of enucleated activated oocytes. Biol. Reprod., 50:1385–1393.
4.
CampbellK.H., LoiP., OtaeguiP.J., WilmutI.1996a. Cell cycle co-ordination in embryo cloning by nuclear transfer. Rev. Reprod., 1:40–46.
5.
CampbellK.H., McWhirJ., RitchieW.A., WilmutI.1996b. Sheep cloned by nuclear transfer from a cultured cell line. Nature, 380:64–66.
6.
CampbellK.H., AlberioR., LeeJ.H., RitchieW.A.2001. Nuclear transfer in practice. Cloning Stem Cells, 3:201–208.
7.
ChoiI., LeeJ.H., FisherP., CampbellK.H.2010. Caffeine treatment of ovine cytoplasts regulates gene expression and foetal development of embryos produced by somatic cell nuclear transfer. Mol. Reprod. Dev., 77:876–887.
8.
ClarkA.J.2002. Generation of transgenic livestock by pronuclear injection. Methods Mol. Biol., 180:273–287.
9.
DasZ.C., GuptaM.K., UhmS.J., LeeH.T.2010. Lyophilized somatic cells direct embryonic development after whole cell intracytoplasmic injection into pig oocytes. Cryobiology, 61:220–224.
10.
De AzevedoW.F., LeclercS., MeijerL., HavlicekL., StrnadM., KimS.H.1997. Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. Eur. J. Biochem., 243:518–526.
11.
DenningC., BurlS., AinslieA., BrackenJ., DinnyesA., FletcherJ., KingT., RitchieM., RitchieW.A., RolloM., de SousaP., TraversA., WilmutI., ClarkA.J.2001. Deletion of the alpha(1,3)galactosyl transferase (GGTA1) gene and the prion protein (PrP) gene in sheep. Nat. Biotechnol., 19:559–562.
12.
FirstN.L.1990. New animal breeding techniques and their application. J. Reprod. Fertil. Suppl., 41:3–14.
13.
GearheartW.W., SmithC., TeepkerG.1989. Multiple ovulation and embryo manipulation in the improvement of beef cattle: relative theoretical rates of genetic change. J Anim. Sci., 67:2863–2871.
JohnsonR.T., RaoP.N.1970. Mammalian cell fusion: Induction of premature chromosome condensation in interphase nuclei. Nature, 226:717–722.
16.
JohnsonR.T., RaoP.N., HughesH.D.1970. Mammalian cell fusion. III. A HeLa cell inducer of premature chromosome condensation active in cells from a variety of species. J. Cell. Physiol., 76:151–158.
17.
LanzaR.P., CibelliJ.B., WestM.D.1999. Human therapeutic cloning. Nat. Med., 5:975–977.
LoiP., BoyazogluS., GallusM., LeddaS., NaitanaS., WilmutI., CappaiP., CasuS.1997. Embryo cloning in sheep: Work in progress. Theriogenology, 48:1–10.
20.
LoiP., LeddaS., FulkaJ.Jr., CappaiP., MoorR.M.1998. Development of parthenogenetic and cloned ovine embryos: Effect of activation protocols. Biol. Reprod., 58:1177–1187.
21.
LoiP., PtakG., FulkaJ.Jr., CappaiP., ClintonM.2001. Genetic rescue of an endangered mammal by cross-species nuclear transfer using post-mortem somatic cells. Nat. Biotechnol., 19:962–964.
22.
LoiP., ClintonM., BarboniB., FulkaJ.Jr., CappaiP., FeilR., MoorR.M., PtakG.2002. Nuclei of nonviable ovine somatic cells develop into lambs after nuclear transplantation. Biol. Reprod., 67:126–132.
23.
LoiP., MatsukawaK., PtakG., ClintonM., FulkaJ.Jr., NathanY., AravA.2008. Freeze-dried somatic cells direct embryonic development after nuclear transfer. PLoS One, 3:e2978.
24.
McCreathK.J., HowcroftJ., CampbellK.H., ColmanA., SchniekeA.E., KindA.J.2000. Production of gene-targeted sheep by nuclear transfer from cultured somatic cells. Nature, 405:1066–1069.
25.
McGrathJ., SolterD.1984. Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell, 37:179–183.
26.
MosesR.M., MasuiY.1994. Enhancement of mouse egg activation by the kinase inhibitor, 6-dimethylaminopurine (6-DMAP)J. Exp. Zool., 270:211–218.
27.
OguraA., InoueK., WakayamaT.2013. Recent advancements in cloning by somatic ell nuclear transfer. Philos. Trans. R. Soc. Lond. B Biol. Sci., 368:20110329, 10.1098/rstb.2011.0329.
28.
OnoT., MizutaniE., LiC., WakayamaT.2008. Nuclear transfer preserves the nuclear genome of freeze-dried mouse cells. J. Reprod. Dev., 54:486–491.
29.
OtaeguiP.J., O'NeillG.T., CampbellK.H.S., WilmutI.1994. Transfer of nuclei from 8-cell stage mouse embryos following use of nocodazole to control the cell cycle. Mol. Reprod. Dev., 39:147–152.
PolejaevaI.A., CampbellK.H.2000. New advances in somatic cell nuclear transfer: application in transgenesis. Theriogenology, 53:117–126.
32.
PondavenP., MeijerL., BeachD.1990. Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components. Genes Dev., 4:9–17.
33.
ProcházkaR., MotlíkJ., FulkaJ.1989. Activity of maturation promoting factor in pig oocytes after microinjection and serial transfer of maturing cytoplasm. Cell Differ. Dev., 27:175–181.
34.
SchniekeA.E., KindA.J., RitchieW.A., MycockK., ScottA.R., RitchieM., WilmutI., ColmanA., CampbellK.H.1997. Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Science, 278:2130–2133.
35.
SheltonJ.N.1988. Embryo manipulation in research and animal production. Aust. J. Biol. Sci., 41:117–132.
36.
SmithL.C., WilmutI., HunterR.H.F.1988. Influence of cell cycle stage at nuclear transplantation on the development in vitro of mouse embryos. J. Reprod. Fertil., 84:619–624.
37.
SolomonL.M., NollR.C., MordkoffD.S., MurphyP., RolersonM.2009. A brave new beef: The US Food and Drug Administration's review of the safety of cloned animal products. Gend. Med., 6:402–409.
38.
SpemannH.1938. Embryonic Development and Induction. Hafner Publishing Company: New York, 210–211.
39.
Susko-ParrisJ.L., Leibfreid-RutledgeM.L., NortheyD.L., SchutzkusV., FirstN.L.1994. Inhibition of protein kinases after an induced calcium transient causes transition of bovine oocytes to embryonic cycles without meiotic completion. Dev. Biol., 166:729–739.
TakahashiK., YamanakaS.2006. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126:663–676.
42.
TakahashiK., TanabeK., OhnukiM., NaritaM., IchisakaT., TomodaK., YamanakaS.2007. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 30,131:861–872.
43.
ThomsonJ.A., Itskovitz-EldorJ., ShapiroS.S., WaknitzM.A., SwiergielJ.J., MarshallV.S., JonesJ.M.1998. Embryonic stem cell lines derived from human blastocysts. Science, 282:1145–1147.
44.
WakayamaT., YanagimachiR.1998. Development of normal mice from oocytes injected with freeze-dried spermatozoa. Nat. Biotechnol., 16:639–641.
45.
WilladsenS.M.1979. A method for culture of micromanipulated sheep embryos and its use to produce monozygotic twins. Nature, 25,277:298–300.
46.
WilladsenS.M., GodkeR.A.1984. A simple procedure for the production of identical sheep twins. Vet. Rec., 114:240–243.
47.
WilmutI., CampbellK.H.S.1992. Embryo multiplication in livestock: present procedures and the potential for improvement. Embryonic Development and Manipulation in Animal Development. Trends in Research and Applications. GandolfiF., LauriaA.Portland Press: London, 135–145.
48.
WilmutI., SchniekeA.E., McWhirJ., KindA.J., CampbellK.H.S.1997. Viable offspring derived from fetal and adult mammalian cells. Nature, 385:810–813.
