Prospect of Cure in Cancer Care

American Cancer Society . How is chemotherapy used to treat cancer? American Cancer Society , 2020. Online document at https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/chemotherapy/how-is-chemotherapy-used-to-treat-cancer.html Accessed on September 27, 2020 .

Islami F , Siegel RL , Jemal A . The changing landscape of cancer in the USA—Opportunities for advancing prevention and treatment. Nat Rev Clin Oncol, 2020; 17:631.

Miller K , Abraham JH , Rhodes L , et al. Use of the word “cure” in oncology. J Oncol Pract, 2013; 9:e136.

Simpkin AL , Schwartzstein RM . Tolerating uncertainty—The next medical revolution?. N Engl J Med, 2016; 375:1713.

Temel JS , Shaw AT , Greer JA . Challenge of prognostic uncertainty in the modern era of cancer therapeutics. J Clin Oncol, 2016; 34:3605.

Bean R , Bean W . Sir William Osler: Aphorisms from His Bedside Teachings and Writings. New York, NY: Henry Schuman, Inc., 1950.

Djulbegovic B . Articulating and responding to uncertainties in clinical research. J Med Philos, 2007; 32:79.

Schwab A . Epistemic humility and medical practice: Translating epistemic categories into ethical obligations. J Med Philos, 2012; 37:28.

Thomson H . The agony of waiting. New Scient, 2019; 244:42.

Metz T . Medicine without cure?: A cluster analysis of the nature of medicine. J Med Philos, 2018; 43:306.

Gatenby RA , Brown JS . Integrating evolutionary dynamics into cancer therapy. Nat Rev Clin Oncol, 2020; 17:675.

Tannock IF , Hickman JA . Limits to personalized cancer medicine. N Engl J Med, 2016; 375:1289.

Sheng S , Margarida Bernardo M , Dzinic SH , et al. Tackling tumor heterogeneity and phenotypic plasticity in cancer precision medicine: Our experience and a literature review. Cancer Metast Rev, 2018; 37:655.

Hutchinson L . Redefining cancer and cure. Nat Rev Clin Oncol, 2016; 13:199.

Hutchinson L . Tumour response, correlates of survival and clinical benefit. Nat Rev Clin Oncol, 2015; 12:433.

Dasgupta A , Lim AR , Ghajar CM . Circulating and disseminated tumor cells: Harbingers or initiators of metastasis?. Mol Oncol, 2017; 11:40.

Cristofanilli M , Pierga JY , Reuben J , et al. The clinical use of circulating tumor cells (CTCs) enumeration for staging of metastatic breast cancer (MBC): International expert consensus paper. Crit Rev Oncol Hematol, 2019; 134:39.

Gradishar WJ , Anderson BO , Balassanian R , et al. Breast Cancer, Version 4.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw, 2018; 16:310.

Pantel K , Alix-Panabieres C . Liquid biopsy and minimal residual disease—Latest advances and implications for cure. Nat Rev Clin Oncol, 2019; 16:409.

Mangan L. War in the Blood review—Love, hope and the search for a cancer cure. The Guardian, Guardian News and Media Limited, July 8, 2019.

Reisfield GM , Wilson GR . Use of metaphor in the discourse on cancer. J Clin Oncol, 2004; 22:4024.

Farrell MJ . The combative language of cancer: A plea for an armistice. J Clin Oncol, 2020; 38:3449.

Kruijff S , Van Zweden C . The harmful impact of the rhetoric “war on cancer”. Eur J Surg Oncol, 2017; 43:963.

Hanahan D . Rethinking the war on cancer. Lancet, 2014; 383:558.

Narod S . Can advanced-stage ovarian cancer be cured?. Nat Rev Clin Oncol, 2016; 13:255.

Fredriksen S . Luck, risk, and blame. J Med Philos, 2005; 30:535.

Passaro A , Spitaleri G , Gyawali B , et al. Immunotherapy in non-small-cell lung cancer patients with performance status 2: Clinical decision making with scant evidence. J Clin Oncol, 2019; 37:1863.

Yurkovich JT , Tian Q , Price ND , et al. A systems approach to clinical oncology uses deep phenotyping to deliver personalized care. Nat Rev Clin Oncol, 2020; 17:183.

Guerra Liberal FDC , O'Sullivan JM , McMahon SJ , et al. Targeted alpha therapy: Current clinical applications. Cancer Biother Radiopharm, 2020; 35:404–417.

Sathekge M , Bruchertseifer F , Vorster M , et al. Predictors of overall and disease-free survival in metastatic castration-resistant prostate cancer patients receiving (225)Ac-PSMA-617 radioligand therapy. J Nucl Med, 2020; 61:62.

Rathke H , Bruchertseifer F , Kratochwil C , et al. First patient exceeding 5-year complete remission after (225)Ac-PSMA-TAT. Eur J Nucl Med Mol Imaging 2020. DOI: 10.1007/s00259-020-04875-y.

Urbanska AM , Khanin R , Alidori S , et al. A genomic profile of local immunity in the melanoma microenvironment following treatment with alpha particle-emitting ultrasmall silica nanoparticles. Cancer Biother Radiopharm, 2020; 35:459.

Schildmann J , Nadolny S , Buiting HM . What do we mean by “palliative” or “oncologic care”? Conceptual clarity is needed for sound research and good care. J Clin Oncol, 2020; 38:2814.

Back AL , Arnold RM , Baile WF , et al. Approaching difficult communication tasks in oncology. CA Cancer J Clin, 2005; 55:164.

Emanuel EJ , Young-Xu Y , Levinsky NG , et al. Chemotherapy use among Medicare beneficiaries at the end of life. Ann Intern Med, 2003; 138:639.

El-Jawahri A , LeBlanc TW , Lee SJ . Reply to J. Schildmann et al. J Clin Oncol, 2020; 38:2815.

El-Jawahri A , Nelson AM , Gray TF , et al. Palliative and end-of-life care for patients with hematologic malignancies. J Clin Oncol, 2020; 38:944.

Shin DW , Cho J , Kim SY , et al. Patients' and family caregivers' understanding of the cancer stage, treatment goal, and chance of cure: A study with patient-caregiver-physician triad. Psychooncology, 2018; 27:106.

Mack JW , Walling A , Dy S , et al. Patient beliefs that chemotherapy may be curative and care received at the end of life among patients with metastatic lung and colorectal cancer. Cancer, 2015; 121:1891.

Berry SR . Just say die. J Clin Oncol, 2008; 26:157.

Odai-Afotey A , Kliss A , Hafler J , et al. Defining the patient experience in medical oncology. Support Care Cancer, 2020; 28:1649.

Jenkins V , Solis-Trapala I , Langridge C , et al. What oncologists believe they said and what patients believe they heard: An analysis of phase I trial discussions. J Clin Oncol, 2011; 29:61.

Schilsky RL , Nass S , Le Beau MM , et al. Progress in cancer research, prevention, and care. N Engl J Med, 2020; 383:897.

Robert C , Marabelle A , Herrscher H , et al. Immunotherapy discontinuation—How, and when? Data from melanoma as a paradigm. Nat Rev Clin Oncol, 2020; 17:707.

Robert C , Ribas A , Hamid O , et al. Durable complete response after discontinuation of pembrolizumab in patients with metastatic melanoma. J Clin Oncol, 2018; 36:1668.

Knox JBL . The vitality of mortality: Being-toward-death and long-term cancer survivorship. J Med Philos, 2020; 45:703.

Langbaum T , Smith TJ . Time to study metastatic-cancer survivorship. N Engl J Med, 2019; 380:1300.

Musschenga B . Is there a problem with false hope?. J Med Philos, 2019; 44:423.

Corn BW , Feldman DB , Wexler I . The science of hope. Lancet Oncol, 2020; 21:e452.