Role of Thyroglobulin Doubling Time in Differentiated Thyroid Cancer and Its Relationship with Demographic-Histopathologic Risk Factors and 18 F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Parameters

Abstract

Background:

Aim of this study was to investigate the relationship between thyroglobulin doubling time (TgDT) and basal risk factors and metabolic parameters derived from ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in differentiated thyroid cancer (DTC).

Materials and Methods:

An analysis of 95 DTC patients who had rising serum thyroglobulin (Tg) levels under levothyroxine (LT4) suppression after radioiodine therapy was made. TgDT was calculated for 28/95 patients. The relationship between TgDT and basal demographic and histopathologic risk factors, preablative Tg, and antithyroglobulin antibody (ATg) levels and metabolic parameters was analyzed.

Results:

In 28 patients (15M, 13F, mean age: 52.6 ± 17.6) that TgDT could be calculated, ¹⁸F-FDG PET/CT was positive in 12 patients. Median TgDT was lower in ¹⁸F-FDG PET/CT positive patients compared to the negative cases (p < 0.05). Patients with skeletal metastasis or local recurrence had a shorter DT compared to the patients with lung metastasis. TgDT was correlated with peak standardized uptake value (SUV_peak) (p < 0.05). Maximum standardized uptake value (SUV_max) was correlated with tumor size (p < 0.05) and mean standardized uptake value (SUV_mean) with tumor size and vascular invasion (p < 0.05). Median SUV_max and SUV_mean were higher in follicular cancer or poor histological variants of papillary DTC compared to papillary cancer classical variant patients

Conclusion:

TgDT may be predictive of a positive ¹⁸F-FDG PET/CT in DTC. Skeletal metastasis and local recurrence are related to shorter TgDT. Greater tumor size, vascular invasion, and follicular cancer or poor variants of papillary carcinoma are related with higher SUV_max and SUV_mean. Larger scale studies are needed to confirm results and to calculate a possible cutoff of TgDT for a positive ¹⁸F-FDG PET/CT study.