Abstract
A facile, viable, “green” two-step, inexpensive technique was developed for the preparation of 32P patch for the treatment of skin cancer. This technique consists of impregnation of H3 32PO4 solution into an inert solid carrier followed by immobilization into a nonleachable matrix by lamination. The morphology of the impregnated paper was evaluated by scanning electron microscope and energy-dispersive spectral analyses. Radioactive patches containing up to ∼37 MBq/cm2 of 32P could be prepared. Distribution of 32P on sources was uniform and release of 32P from the sealed source in water and saline was found to be well within the permissible levels of 185 Bq. Custom-shaped 32P-patches after quality assurance were supplied to AIIMS, New Delhi, for clinical evaluation. 32P-impregnated paper protected by a laminated film holds promise for treatment of superficial cancers.
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