Objectives: The aim of this study was to evaluate the brachytherapy effectiveness of I125 seeds combined with artificial prosthesis in malignant sarcoma therapy.
Methods: The combination of I125 seeds and artificial prosthesis was implanted to replace tumor section for three clinical cases—2 malignant osteosarcoma patients and 1 malignant soft-tissue tumor patient— through the direct operation.
Results: Approximately 14–18 months after the operation, the results of our postoperational investigation showed that the tumor tissues of 3 patients had been completely removed. The limb functions recovered well. The brachytherapy of the combination of I125 seeds and artificial prosthesis in malignant tumor improved the curative effect. No tumor existed, and no infection occurred.
Conclusions: It was demonstrated that this method was safe and easy. No side-effect was observed after the implantation of I125 seeds. The brachytherapy was proven to be a potential method for patients who were at high risk to recrudesce the malignant osteosarcoma of tumors after the tumor excision.
