Combined Topiramate and Metformin Pharmacotherapy for Second-Generation Antipsychotic-Induced Weight Gain in Pediatric Bipolar Disorder and Aggression

Adachi N , Fenwick P , Akanuma N , Hara K , Ishii R , Okazaki M , Ito M , Sekimoto M , Kato M , Onuma T : Increased frequency of psychosis after second-generation antiepileptic drug administration in adults with focal epilepsy. Epilepsy Behav, 97:138–143, 2019.

Adan RAH : Mechanisms underlying current and future anti-obesity drugs. Trends Neurosci, 36:133–140, 2013.

Barker MK , Sable CM , Montgomery SE , Chow L , Green TJ , Panagiotopoulos C , Devlin AM : Diet and cardiometabolic side effects in children treated with second-generation antipsychotics. Clin Nutr ESPEN, 23:205–211, 2018.

Barzman DH , DelBello MP , Kowatch RA , Warner J , Rofey D , Stanford K , Rappaport K , Daniels JP , Strakowski SM : Adjunctive topiramate in hospitalized children and adolescents with bipolar disorders. J Child Adolesc Psychopharmacol, 15:931–937, 2005.

Berlin H : Antiepileptic drugs for the treatment of impulsivity. Curr Psychiatry Rev, 4:114–136, 2008.

Chung ST , Onuzuruike AU , Magge SN : Cardiometabolic risk in obese children. Ann N Y Acad Sci, 1411:166–183, 2018.

Coomans CP , Geerling JJ , van den Berg SAA , van Diepen HC , Garcia-Tardón N , Thomas A , Schröder-van der Elst JP , Ouwens DM , Pijl H , Rensen PCN , Havekes LM , Guigas B , Romijn JA : The insulin sensitizing effect of topiramate involves K ATP channel activation in the central nervous system. Br J Pharmacol, 170:908–918, 2013.

Correll CU , Sikich L , Reeves G , Johnson J , Keeton C , Spanos M , Kapoor S , Bussell K , Miller L , Chandrasekhar T , Sheridan EM , Pirmohamed S , Reinblatt SP , Alderman C , Scheer A , Borner I , Bethea TC , Edwards S , Hamer RM , Riddle MA : Metformin add-on vs. antipsychotic switch vs. continued antipsychotic treatment plus healthy lifestyle education in overweight or obese youth with severe mental illness: Results from the IMPACT trial. World Psychiatry, 19:69–80, 2020.

Czepiel KS , Perez NP , Campoverde Reyes KJ , Sabharwal S , Stanford FC : Pharmacotherapy for the treatment of overweight and obesity in children, adolescents, and young adults in a large health system in the US. Front Endocrinol (Lausanne), 11:290, 2020.

Daviss WB , Barnett E , Neubacher K , Drake RE : Use of antipsychotic medications for nonpsychotic children: Risks and implications for mental health services. Psychiatr Serv, 67:339–341, 2016.

Dayabandara M , Hanwella R , Ratnatunga S , Seneviratne S , Suraweera C , de Silva V : Antipsychotic-associated weight gain: Management strategies and impact on treatment adherence. Neuropsychiatr Dis Treat, 13:2231–2241, 2017.

DelBello MP , Kowatch RA , Warner J , Schwiers ML , Rappaport KB , Daniels JP , Foster KD , Strakowski SM : Adjunctive topiramate treatment for pediatric bipolar disorder: A retrospective chart review. J Child Adolesc Psychopharmacol, 12:323–330, 2002.

Ellinger LK , Ipema HJ , Stachnik JM : Efficacy of metformin and topiramate in prevention and treatment of second-generation antipsychotic-induced weight gain. Ann Pharmacother, 44:668–679, 2010.

Ellul P , Delorme R , Cortese S : Metformin for weight gain associated with second-generation antipsychotics in children and adolescents: A systematic review and meta-analysis. CNS Drugs, 32:1103–1112, 2018.

Marangoni C , De Chiara L , Faedda GL : Bipolar disorder and ADHD: Comorbidity and diagnostic distinctions. Curr Psychiatry Rep, 17:604, 2015.

Masi G , Sesso G , Pfanner C , Valente E , Molesti A , Placini F , Boldrini S , Loriaux N , Drago F , Montesanto AR , Pisano S , Milone A : An exploratory study of emotional dysregulation dimensions in youth with attention deficit hyperactivity disorder and/or bipolar spectrum disorders. Front Psychiatry 12, 2021.

Moavero R , Santarone ME , Galasso C , Curatolo P : Cognitive and behavioral effects of new antiepileptic drugs in pediatric epilepsy. Brain Dev, 39:464–469, 2017.

Munshi KR , Oken T , Guild DJ , Trivedi HK , Wang BC , Ducharme P , Gonzalez-Heydrich J : The use of antiepileptic drugs (AEDs) for the treatment of pediatric aggression and mood disorders. Pharmaceuticals (Basel), 3:2986–3004, 2010.

Nikou AF , Lai M , Solmssen C , Bhargava M , Ben-David K , Ramsubick C , Rice T , Coffey B : Topiramate for posttraumatic symptoms in an obese adolescent girl. J Child Adolesc Psychopharmacol, 31:235–241, 2021.

Rice TR , Walther A : Male-specific metabolic considerations concerning the prescription of second-generation antipsychotics to adolescents. J Child Adolesc Psychopharmacol, 31:53–55, 2020.

Simonetti A , Koukopoulos AE , Kotzalidis GD , Janiri D , De Chiara L , Janiri L , Sani G : Stabilization beyond mood: Stabilizing patients with bipolar disorder in the various phases of life. Front Psychiatry, 11:247, 2020.

Singh T : Pediatric bipolar disorder: Diagnostic challenges in identifying symptoms and course of illness. Psychiatry (Edgmont), 5:34–42, 2008.

Smith C , Myles H , Galletly C : Developing a metformin prescribing tool for use in adults with mental illness to reduce medication-related weight gain and cardiovascular risk. Australas Psychiatry, 25:387–390, 2017.

Stanley BG : GABA: A cotransmitter linking leptin to obesity prevention. Endocrinology, 153:2057–2058, 2012.

Wróbel MP , Marek B , Kajdaniuk D , Rokicka D , Szymborska-Kajanek A , Strojek K : Metformin—A new old drug. Endokrynol Pol, 68:482–496, 2017.

Zhuo C , Xu Y , Liu S , Li J , Zheng Q , Gao X , Li S , Jing R , Song X , Yue W , Zhou C , Upthegrove R : Topiramate and metformin are effective add-on treatments in controlling antipsychotic-induced weight gain: A systematic review and network meta-analysis. Front Pharmacol, 9:1393, 2018.