The article puts into perspective the recent discovery of cannabidiol crystal polymorph Form 2.
Get full access to this article
View all access options for this article.
References
1.
TanneyCAS, BackerR, GeitmannA, et al.Cannabis glandular trichomes: A cellular metabolite factory. Front Plant Sci, 2021; 12:721986.
2.
RadwanMM, ChandraS, GulS, et al.Cannabinoids, phenolics, terpenes and alkaloids of cannabis. Molecules, 2021; 26(9):2774.
3.
Rifkin-ZybutzR, ErridgeS, HolveyC, et al.Clinical outcome data of anxiety patients treated with cannabis-based medicinal products in the United Kingdom: A cohort study from the UK Medical Cannabis Registry. Psychopharmacology, 2023; 240(8):1735–1745.
4.
StrakerHE, McMillanL, MardianaL, et al.Polymorph prediction through observed structural isomorphism leading to a new crystalline form of cannabidiol. CrystEngComm, 2023; 25(16):2479–2484.
5.
CorpinotMK, BucarD-K. A practical guide to the design of molecular crystals. Cryst Growth Des, 2019; 19(2):1426–1453.
6.
MitscherlichE. On the relationship between crystalline form and chemical composition I. Note on arsenates and phosphates. Ann Chim Phys, 1822; 19:350–419.
7.
Cruz-CabezaAJ, Reutzel-EdensSM, BernsteinJ. Facts and fictions about polymorphism. Chem Soc Rev, 2015; 44(23):8619–8635.
8.
JonesPG, FalvelloL, KennardO, et al.Cannabidiol. Acta Crystallogr B, 1977; 33(10):3211–3214.
9.
TylerAR, RagbirsinghR, McMonagleCJ, et al.Encapsulated nanodroplet crystallization of organic-soluble small molecules. Chem, 2020; 6(7):1755–1765.
10.
FormatoM, CrescenteG, ScognamiglioM, et al.(-)-Cannabidiolic acid, a still overlooked bioactive compound: An introductory review and preliminary research. Molecules, 2020; 25(11):2638.