A central goal of the Academy of Breastfeeding Medicine is the development of clinical protocols for managing common medical problems that may impact breastfeeding success. These protocols serve only as guidelines for the care of breastfeeding mothers and infants and do not delineate an exclusive course of treatment or serve as standards of medical care. Variations in treatment may be appropriate according to the needs of an individual patient.
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References
1.
LiR, FeinSB, ChenJ, et al.Why mothers stop breastfeeding: Mothers' self-reported reasons for stopping during the first year. Pediatrics, 2008; 122(Suppl 2):S69–S76.
2.
RobertE, CoppietersY, SwennenB, et al.The reasons for early weaning, perceived insufficient breast milk, and maternal dissatisfaction: Comparative studies in two belgian regions. Int Sch Res Not, 2014; 2014:678564.
3.
HauckY, FenwickJ, DhaliwalSS, et al.A Western Australian survey of breastfeeding initiation, prevalence and early cessation patterns. Matern Child Health J, 2011; 15:260–268.
4.
GattiL.Maternal perceptions of insufficient milk supply in breastfeeding. J Nurs Scholarsh, 2008; 40:355–363.
CoxD, OwensR, HartmannP. Blood and milk prolactin and the rate of milk synthesis in women. Exp Physiol, 1996; 81:1007–1020.
7.
CzankC, HendersonJL, KentJC, et al.Hormonal control of the lactation cycle. In: Hale & Hartmann's Textbook of Human Lactation, HaleTW, HartmannPE, eds. Amarillo, TX: Hale Publishing, 2007, pp. 89–111.
8.
DalyS, HartmannP. Infant demand and milk supply. Part 1: Infant demand and milk production in lactating women. J Hum Lact, 1995; 11:21–26.
9.
DalyS, HartmannP. Infant demand and milk supply. Part 2: The short-term control of milk synthesis in lactating women. J Hum Lact, 1995; 11:27–37.
10.
ReismanT, GoldsteinZ. Case report: Induced lactation in a transgender woman. Transgend Health, 2018; 3:24–26.
11.
MilsomS, BreierB, GallaherB, et al.Growth hormone stimulates galactopoiesis in healthy lactating women. Acta Endocrinol, 1992; 127:337–343.
12.
GunnA, GunnT, RaboneD, et al.Growth hormone increases breast milk volumes in mothers of preterm infants. Pediatrics, 1996; 98:279–282.
13.
MilsomS, RaboneD, GunnA, et al.Potential role for growth hormone in human lactation insufficiency. Horm Res, 1998; 50:147–150.
14.
ShekelleP, WoolfS, EcclesM, et al.Developing guidelines. Br Med J, 1999; 318:593–596.
15.
AonoT, AkiT, KoikeK, et al.Effect of sulpiride on poor puerperal lactation. Am J Obstet Gynecol, 1982; 143:927–932.
16.
YlikorkalaO, KauppilaA, KivinenS, et al.Sulpiride improves inadequate lactation. Br Med J, 1982; 285:249–251.
TysonJ, PerezA, ZanartuJ. Human lactational response to oral thyrotropin releasing hormone. J Clin Endocrinol Metab, 1976; 43:760–768.
19.
da SilvaOP, KnoppertDC, AngeliniMM, et al.Effect of domperidone on milk production in mothers of premature newborns: A randomized, double-blind, placebo-controlled trial. Can Med Assoc J, 2001; 164:17–21.
20.
KauppilaA, KivinenS, YlikorkalaO. Metoclopramide increases prolactin release and milk secretion in puerperium without stimulating the secretion of thyrotropin and thyroid hormones. J Clin Endocrinol Metab, 1981; 52:436–439.
21.
DonovanTJ, BuchananK. Medications for increasing milk supply in mothers expressing breastmilk for their preterm hospitalised infants. Cochrane Database Syst Rev, 2012; 3:CD005544.
22.
BazzanoA, HoferR, ThibeauS, et al.A review of herbal and pharmaceutical galactagogues for breast-feeding. Ochsner J, 2016; 16:511–524.
23.
GrzeskowiakL, SmithersL, AmirL, et al.Domperidone for increasing breast milk volume in mothers expressing breast milk for their preterm infants: A systematic review and meta-analysis. BJOG, 2018 [Epub ahead of print]; DOI: 10.1111/1471-0528.15177.
24.
JantarasaengaramS, SreewapaP. Effects of domperidone on augmentation of lactation following cesarean delivery at full term. Int J Gynaecol Obstet, 2012; 116:240–243.
25.
KnoppertDC, PageA, WarrenJ, et al.The effect of two different domperidone doses on maternal milk production. J Hum Lact, 2013; 29:38–44.
26.
IngramJ, TaylorH, ChurchillC, et al.Metoclopramide or domperidone for increasing maternal breast milk output: A randomised controlled trial. Arch Dis Child Fetal Neonatal Ed, 2012; 97:F241–F245.
27.
AsztalosEV, Campbell-YeoM, da SilvaOP, et al.Enhancing human milk production with domperidone in mothers of preterm infants. J Hum Lact, 2017; 33:181–187.
28.
WanEWX, DaveyK, Page-SharpM, et al.Dose-effect study of domperidone as a galactagogue in preterm mothers with insufficient milk supply, and its transfer into milk. Br J Clin Pharmacol, 2008; 66:283–289.
29.
DoggrellSA, HancoxJC. Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine. Expert Opinion On Drug Safety, 2014; 13:131–138.
30.
LeelakanokN, HolcombeA, SchweizerML. Domperidone and risk of ventricular arrhythmia and cardiac death: A systematic review and meta-analysis. Clin Drug Investig, 2016; 36:97.
31.
SmolinaK, MintzesK, HanleyGE, et al.The association between domperidone and ventricular arrhythmia in the postpartum period. Pharmacoepidemiol Drug Saf, 2016; 25:1210–1214.
32.
GrzeskowiakLE.Domperidone for lactation: What health care providers really should know. Obstet Gynecol, 2017; 130:913.
33.
LewisPJ, DevenishC, KahnC. Controlled trial of metoclopramide in the initiation of breast feeding. Br J Clin Pharmacol, 1980; 9:217–219.
34.
HansenW, McAndrewS, HarrisL, et al.Metoclopramide effect on breastfeeding the preterm infant: A randomized trial. Obstet Gynecol, 2005; 105:383–389.
35.
SakhaK, BehbahanA. Training for perfect breastfeeding or metoclopramide: Which one can promote lactation in nursing mothers?. Breastfeed Med, 2008; 3:120–123.
36.
Seema, PatwariAK, SatyanarayanaL. Relactation: An effective intervention to promote exclusive breastfeeding. J Trop Pediatr, 1997; 43:213–216.
37.
FifeS, GillP, HopkinsM, et al.Metoclopramide to augment lactation, does it work? A randomized trial. J Matern Fetal Neonatal Med, 2011; 24:1317–1320.
38.
KauppilaA, AnuntiP, KivinenS, et al.Metoclopramide and breast feeding: Efficacy and anterior pituitary responses of the mother and child. Eur J Obstet Gynecol, 1985; 19:19–22.
39.
ErtlT, SulyokE, EzerE, et al.Metoclopramide on the composition of human breast milk. Acta Paediatr Hung, 1991; 31:415–422.
40.
de GezelleH, OogheW, ThieryM, et al.Metoclopramide and breast milk. Eur J Obstet Gynecol, 1983; 15:31–36.
41.
GuzmanV, ToscanoG, CanalesE, et al.Improvement of defective lactation by using oral metoclopramide. Acta Obstet Gynecol Scand, 1979; 58:53–55.
42.
KauppilaA, KivinenS, YlikorkalaO. A dose response relation between improved lactation and metoclopramide. Lancet, 1981; 1:1175–1177.
43.
ToppareM, LaleliY, SensesD, et al.Metoclopramide for breast milk production. Nutr Res, 1994; 14:1019–1029.
44.
EhrenkrantzR, AckermanB. Metoclopramide effect on faltering milk production by mothers of premature infants. Pediatrics, 1986; 78:614.
45.
GuptaAP, GuptaPK. Metoclopramide as a lactogogue. Clin Pediatr, 1985; 24:269–272.
46.
TolinoA, TedeschiA, FaraceR, et al.The relationship between metocolpramide and milk secretion in puerperium. Clin Exp Obstet Gynecol, 1981; 8:93–95.
47.
SewellCA, ChangCY, ChehabMM, et al.Domperidone for lactation: What health care providers need to know. Obstet Gynecol, 2017; 129:1054–1058.
Kim-GodwinY.Postpartum beliefs and practices among non-Western cultures. MCN Am J Matern Child Nurs, 2003; 28:74–78.
50.
KimM-K, ShinJ-S, PatelRA, et al.The effects of pigs' feet consumption on lactation. Ecol Food Nutr, 2013; 52:223–238.
51.
ThaweekulP, ThaweekulY, SritipsukhoP. The efficacy of hospital-based food program as galactogogues in early period of lactation. J Med Assoc Thai, 2014; 97:478–482.
52.
ÖzalkayaE, AslandoğduZ, ÖzkoralA, et al.Effect of a galactagogue herbal tea on breast milk production and prolactin secretion by mothers of preterm babies. Niger J Clin Pract, 2018; 21:38–42.
53.
MortelM, MehtaSD. Systematic review of the efficacy of herbal galactogogues. J Hum Lact, 2013; 29:154–162.
GrzeskowiakLE, AmirLH. Pharmacological management of low milk supply with domperidone: Separating fact from fiction. Med J Aust, 2014; 201:257–258.
61.
Campbell-YeoML, AllenAC, JosephKS, et al.Effect of domperidone on the composition of preterm human breast milk. Pediatrics, 2010; 125:e107–e114.
62.
TurkyılmazC, OnalE, HirfanogluIM, et al.The effect of galactagogue herbal tea on breast milk production and short-term catch-up of birth weight in the first week of life. J Altern Complement Med, 2011; 17:139–142.
63.
DamanikR, WahlqvistML, WattanapenpaiboonN. Lactagogue effects of Torbangun, a Bataknese traditional cuisine. Asia Pac J Clin Nutr, 2006; 15:267–274.
64.
KhanTM, WuDB-C, DolzhenkoAV. Effectiveness of fenugreek as a galactagogue: A network meta-analysis. Phytother Res, 2018; 32:402–412.
65.
ReederC, LegrandA, O'Connor-VonSK. The effect of fenugreek on milk production and prolactin levels in mothers of preterm infants. Clin Lact, 2013; 4:159–165.
Di PierroF, CallegariA, CarotenutoD, TapiaMM. Clinical efficacy, safety and tolerability of BIO-C (micronized Silymarin) as a galactagogue. Acta Biomed, 2008; 79:205–210.
68.
JellinJ, GregoryP, BatzF, et al.Natural Medicines Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2009.
69.
SerraoF, CorselloM, RomagnoliC, et al.The long-term efficacy of a galactagogue containing Sylimarin-Phosphatidylserine and Galega on milk production of mothers of preterm infants. Breastfeed Med, 2018; 13:67–69.
70.
ZeccaE, ZuppaA, D'AntuonoA, et al.Efficacy of a galactogogue containing silymarin-phosphatidylserine and galega in mothers of preterm infants: A randomized controlled trial. Eur J Clin Nutr, 2016; 70:1151–1154.
71.
Low DogT.The use of botanicals during pregnancy and lactation. Altern Ther Health Med, 2009; 15:54–58.
72.
DoyleM, GrossmanM.Case report: Domperidone use as a galactagogue resulting in withdrawal symptoms upon discontinuation. Arch Womens Ment Health, 2017 [Epub ahead of print]; DOI: 10.1007/s00737-017-0796-8.
73.
DjeddiD, KongolaG, LefaixC, et al.Effect of domperidone on QT interval in neonates. J Pediatr, 2008; 153:663–666.
