Low-Density Lipoprotein Cholesterol Improvement Is Greater After Laparoscopic Sleeve Gastrectomy as Compared with Laparoscopic Gastric Bypass—a Registry-Based Study with 1-Year Follow-Up

Abstract

Background:

Obesity is associated with an increased cardiovascular risk and deteriorated lipid profile. Both laparoscopic sleeve gastrectomy (LSG) and laparoscopic gastric bypass (LGBP) have shown favorable effects on lipid profile, but disagreement prevails regarding which method might better resolve dyslipidemia. This study adds an interesting observation to the research field, exploring the changes in lipid profile 12 months after LSG versus LGBP.

Methods:

Lipid outcome 12 months postsurgery was compared between LSG and LGBP using data from the quality registry Scandinavian Obesity Surgery Registry. The main focus was the outcome of lipid profile, whereas secondary outcomes comprised total weight loss (TWL), body mass index decrease, and other metabolic laboratory findings.

Results:

The study included 633 patients, 319 versus 317 underwent LSG and LGBP, respectively. A significant improvement in lipid profile 12 months after surgery was seen in both groups. However, the LSG group had a greater effect change on low-density lipoprotein (LDL) as compared with the LGBP group. Differences between the groups regarding total cholesterol, triglycerides, or high-density lipoprotein (HDL) were nonsignificant.

Conclusion:

Both LGBP and LSG improve lipid profile 12 months after surgery. In this cohort, the relations between LDL and HDL displayed a different pattern in LSG versus LGBP, adding an interesting observation to previously conducted studies.