Abstract
Background:
In obese subjects with type 2 diabetes mellitus (T2DM), the effect of laparoscopic greater curvature plication (LGCP) on the clinical improvement of T2DM is unknown. This study aims to investigate the effect of LGCP in improving the clinical profile of patients with T2DM.
Materials and Methods:
This is a retrospective study of obese subjects with T2DM who underwent LGCP between March 2011 and March 2013. Patients were followed up at different time periods. The efficacy of the procedure was investigated by using chi and t tests. Univariate and multivariate analyses were performed to investigate the predictors of excess weight loss (EWL).
Results:
Forty-three obese subjects (25 females, 18 males) with T2DM were enrolled. Mean age was 41.6 years. Preoperative mean ± SEM body–mass index (BMI) was 44.4 ± 0.8 kg/m2. Mean BMI decreased significantly at 1, 3, 6, and 12 months (p = 0.0002, p < 0.001, p < 0.001, and p < 0.001). Mean EWL was 20%, 32%, 42%, and 48% at 1, 3, 6, and 12 months of follow-up. At 1-year follow-up, a statistically significant decrease in mean serum fasting blood glucose (p = 0.001), HbA1c levels (p = 0.002), and Homeostasis Model Assessment (HOMA) index (p < 0.0001) was observed. Female sex (p = 0.013) and HOMA index (p = 0.009) were found to be independent predictors of EWL.
Conclusion:
LGCP is a safe and effective bariatric procedure for the management of obesity. Our findings show that in addition to significant weight loss, LGCP may contribute to the clinical improvement of T2DM in obese subjects.
Get full access to this article
View all access options for this article.