Spinomeric chemistry is a domain of physical chemistry that explores the role of spin-isomery in chemical reactivity. In large magnetic fields (
B
), chemical structures with three adjacent nuclear spins (such as
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, and
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) form complex spinomers. Known departure from a 1:1 ratio between various types of spinomers opens interesting research avenues in their potential role in asymmetric hydration processes. Recent time domain 1H nuclear magnetic resonance (TD-1HNMR) findings revealed the existence of small, yet consistent,
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-controlled enantio-different proton exchange reactivity in sugars. The mechanisms behind this effect are unclear and may involve spinomer/enantiocenter (e.g.,
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) interactions or spinomer/spinomer (e.g.,
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) interactions. We developed an experimental model that allows for the verification and study of such effects. We used TD-1HNMR at 0.589 T to study and compare proton exchange enantio-differences in asparagine (Asn) and mandelic acid in response to titration with
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at constant pH. Unlike Asn, mandelic acid has no complex spinomer group (such as −NH2) in its chiral center. We report finding enantio-differences regarding ΔpK and 1/T
2(0) correlated with
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, and linear changes in ΔM
2 indicating differences in the affinity of enantiomers for
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surface hydration. These results stress the importance of
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-based spinomeric chemistry in chiral reactivity and open windows toward a novel interpretation of the origin of prebiotic chiral reactivity in the presence of moderately large
B
(such as on magnetic mineral surfaces or on satellites of gaseous giants), as well as toward abiotic isotopic fractionation of
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in the presence of chiral organic molecules. Key Words: Origin of life—Chirality—Mandelic acid—Asparagine—Enantiomers—Spinomers—
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—TD-1HNMR. Astrobiology 9, 697–701.
