Dr. Regina Brigelius-Flohé (PhD 1978) is recognized here as redox pioneer because she has published an article on redox biology, as first author, that has been cited >1000 times, plus four articles cited >500 times, and a total of 30 articles cited >100 times. She obtained her doctorate in biochemistry at the Institute of Biochemistry of the University of Münster, Germany. She held positions in both, academia (Münster, Munich, Düsseldorf, Hannover, and Potsdam, Germany) and industry (Aachen, Germany). Dr. Brigelius-Flohé is the pioneer who, as head of the department of biochemistry of micronutrients of the German Institute of Human Nutrition (DIfE; Potsdam-Rehbrücke, Germany), worked out the metabolism of tocopherols and tocotrienols (“Key Finding 1”). She was the first to sequence glutathione peroxidase 4 (GPx4) (“Key Finding 2”), and unraveled the role of selenium, in particular of GPxs, in inflammation and carcinogenesis (“Key Finding 3”). Her contributions, thus, focused on serious biomedical problems such as nutrition, inflammation, and carcinogenesis. She has been a member of the scientific advisory board of the German Society of Biochemistry and Molecular Biology for 6 years and was president of SFRR-Europe in 2005–2006. She edited several books and serves on the editorial board of journals in the fields of nutrition, free radicals, and redox regulation. Antioxid. Redox Signal. 35, 595–601.
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References
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2.
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BanningA, FlorianS, DeubelS, ThalmannS, Müller-SchmehlK, JacobaschG, and Brigelius-FlohéR. GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells. Antioxid Redox Signal, 10: 1491–1500, 2008.
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BanningA, KippA, SchmitmeierS, LowingerM, FlorianS, KrehlS, ThalmannS, ThierbachR, SteinbergP, and Brigelius-FlohéR. Glutathione peroxidase 2 inhibits cyclooxygenase-2-mediated migration and invasion of HT-29 adenocarcinoma cells but supports their growth as tumors in nude mice. Cancer Res, 68: 9746–9753, 2008.
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BirringerM, DroganD, and Brigelius-FlohéR. Tocopherols are metabolized in HepG2 cells by side chain omega-oxidation and consecutive beta-oxidation. Free Radic Biol Med, 31: 226–232, 2001.
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BirringerM, PflugerP, KluthD, LandesN, and Brigelius-FlohéR. Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells. J Nutr, 132: 3113–3118, 2002.
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