Reactive oxygen species (ROS) have been associated with various human diseases, and considerable attention has been paid to investigate their physiological effects. Various ROS are synthesized in the mitochondria and accumulate in the cytoplasm if the cellular antioxidant defense mechanism fails. The critical balance of this ROS synthesis and antioxidant defense systems is termed the redox system of the cell. Various cardiovascular diseases have also been affected by redox to different degrees. ROS have been indicated as both detrimental and protective, via different cellular pathways, for cardiac myocyte functions, electrophysiology, and pharmacology. Mostly, the ROS functions depend on the type and amount of ROS synthesized. While the literature clearly indicates ROS effects on cardiac contractility, their effects on cardiac excitability are relatively under appreciated. Cardiac excitability depends on the functions of various cardiac sarcolemal or mitochondrial ion channels carrying various depolarizing or repolarizing currents that also maintain cellular ionic homeostasis. ROS alter the functions of these ion channels to various degrees to determine excitability by affecting the cellular resting potential and the morphology of the cardiac action potential. Thus, redox balance regulates cardiac excitability, and under pathological regulation, may alter action potential propagation to cause arrhythmia. Understanding how redox affects cellular excitability may lead to potential prophylaxis or treatment for various arrhythmias. This review will focus on the studies of redox and cardiac excitation. Antioxid. Redox Signal. 18, 432–468.
AbrielH. Cardiac sodium channel Na(v)1.5 and interacting proteins: Physiology and pathophysiology. J Mol Cell Cardiol, 48:2–11. 2010.
2.
AdachiT, WeisbrodRM, PimentelDR, YingJ, SharovVS, SchoneichC, CohenRA. S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide. Nat Med, 10:1200–1207. 2004.
3.
AhernGP, HsuSF, KlyachkoVA, JacksonMB. Induction of persistent sodium current by exogenous and endogenous nitric oxide. J Biol Chem, 275:28810–28815. 2000.
4.
AhmmedGU, XuY, Hong DongP, ZhangZ, EiserichJ, ChiamvimonvatN. Nitric oxide modulates cardiac Na(+) channel via protein kinase A and protein kinase G. Circ Res, 89:1005–1013. 2001.
5.
AibaT, HeskethGG, LiuT, CarlisleR, Villa-AbrilleMC, O'RourkeB, AkarFG, TomaselliGF. Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes. Cardiovasc Res, 85:454–463. 2010.
6.
AikensJ, DixTA. Perhydroxyl radical (HOO.) initiated lipid peroxidation. The role of fatty acid hydroperoxides. J Biol Chem, 266:15091–15098. 1991.
7.
AkrouhA, HalcombSE, NicholsCG, Sala-RabanalM. Molecular biology of K(ATP) channels and implications for health and disease. IUBMB Life, 61:971–978. 2009.
AnzaiK, OgawaK, KuniyasuA, OzawaT, YamamotoH, NakayamaH. Effects of hydroxyl radical and sulfhydryl reagents on the open probability of the purified cardiac ryanodine receptor channel incorporated into planar lipid bilayers. Biochem Biophys Res Commun, 249:938–942. 1998.
10.
AonMA, CortassaS, MaackC, O'RourkeB. Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status. J Biol Chem, 282:21889–21900. 2007.
11.
AonMA, CortassaS, MarbanE, O'RourkeB. Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes. J Biol Chem, 278:44735–44744. 2003.
12.
AonMA, CortassaS, O'RourkeB. Mitochondrial oscillations in physiology and pathophysiology. Adv Exp Med Biol, 641:98–117. 2008.
ArmoundasAA, HobaiIA, TomaselliGF, WinslowRL, O'RourkeB. Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts. Circ Res, 93:46–53. 2003.
15.
AronsonD, MittlemanMA, BurgerAJ. Effects of sulfonylurea hypoglycemic agents and adenosine triphosphate dependent potassium channel antagonists on ventricular arrhythmias in patients with decompensated heart failure. Pacing Clin Electrophysiol, 26:1254–1261. 2003.
16.
AvkiranM, HaworthRS. Regulatory effects of G protein-coupled receptors on cardiac sarcolemmal Na+/H+ exchanger activity: signalling and significance. Cardiovasc Res, 57:942–952. 2003.
BhatnagarA. Contribution of ATP to oxidative stress-induced changes in action potential of isolated cardiac myocytes. Am J Physiol, 272:H1598–H1608. 1997.
27.
BhatnagarA, SrivastavaSK, SzaboG. Oxidative stress alters specific membrane currents in isolated cardiac myocytes. Circ Res, 67:535–549. 1990.
28.
BianchiL, PrioriSG, NapolitanoC, SurewiczKA, DennisAT, MemmiM, SchwartzPJ, BrownAM. Mechanisms of I(Ks) suppression in LQT1 mutants. Am J Physiol Heart Circ Physiol, 279:H3003–H3011. 2000.
29.
BiliczkiP, ViragL, IostN, PappJG, VarroA. Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve. Br J Pharmacol, 137:361–368. 2002.
30.
BillmanGE. The cardiac sarcolemmal ATP-sensitive potassium channel as a novel target for anti-arrhythmic therapy. Pharmacol Ther, 120:54–70. 2008.
31.
BlaichA, WellingA, FischerS, WegenerJW, KostnerK, HofmannF, MoosmangS. Facilitation of murine cardiac L-type Ca(v)1.2 channel is modulated by calmodulin kinase II-dependent phosphorylation of S1512 and S1570. Proc Natl Acad Sci U S A, 107:10285–10289. 2010.
32.
BlankenbergS, RupprechtHJ, BickelC, TorzewskiM, HafnerG, TiretL, SmiejaM, CambienF, MeyerJ, LacknerKJ. Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. N Engl J Med, 349:1605–1613. 2003.
33.
BondCT, MaylieJ, AdelmanJP. Small-conductance calcium-activated potassium channels. Ann N Y Acad Sci, 868:370–378. 1999.
BoverisA, ChanceB. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J, 134:707–716. 1973.
36.
BowlingN, WalshRA, SongG, EstridgeT, SanduskyGE, FoutsRL, MintzeK, PickardT, RodenR, BristowMR, SabbahHN, MizrahiJL, GromoG, KingGL, VlahosCJ. Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart. Circulation, 99:384–391. 1999.
37.
BoydenPA, BarbhaiyaC, LeeT, ter KeursHE. Nonuniform Ca2+ transients in arrhythmogenic Purkinje cells that survive in the infarcted canine heart. Cardiovasc Res, 57:681–693. 2003.
38.
BrickJE, BrickJF, ElnickiDM. Musculoskeletal disorders. When are they caused by hormone imbalance?Postgrad Med, 90:129–132135–1261991.
39.
BrownDA, AonMA, FrasierCR, SloanRC, MaloneyAH, AndersonEJ, O'RourkeB. Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization. J Mol Cell Cardiol, 48:673–679. 2010.
40.
BrownDA, O'RourkeB. Cardiac mitochondria and arrhythmias. Cardiovasc Res, 88:241–249. 2010.
41.
CampbellDL, StamlerJS, StraussHC. Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols. J Gen Physiol, 108:277–293. 1996.
ChoudharyG, DudleySCJr. Heart failure, oxidative stress, and ion channel modulation. Congest Heart Fail, 8:148–155. 2002.
51.
CiampaEJ, WelchRC, VanoyeCG, GeorgeALJr. KCNE4 juxtamembrane region is required for interaction with calmodulin and for functional suppression of KCNQ1. J Biol Chem, 286:4141–4149. 2011.
52.
ClerkA, MichaelA, SugdenPH. Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes. Biochem J, 333,Pt 3:581–589. 1998.
53.
CoetzeeWA, OpieLH. Effects of oxygen free radicals on isolated cardiac myocytes from guinea-pig ventricle: electrophysiological studies. J Mol Cell Cardiol, 24:651–663. 1992.
54.
CortassaS, AonMA, WinslowRL, O'RourkeB. A mitochondrial oscillator dependent on reactive oxygen species. Biophys J, 87:2060–2073. 2004.
55.
CostaAD, GarlidKD, WestIC, LincolnTM, DowneyJM, CohenMV, CritzSD. Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria. Circ Res, 97:329–336. 2005.
56.
CostaAD, JakobR, CostaCL, AndrukhivK, WestIC, GarlidKD. The mechanism by which the mitochondrial ATP-sensitive K+ channel opening and H2O2 inhibit the mitochondrial permeability transition. J Biol Chem, 281:20801–20808. 2006.
57.
CouchonnalLF, AndersonME. The role of calmodulin kinase II in myocardial physiology and disease. Physiology (Bethesda), 23:151–159. 2008.
58.
CowleyEA, LinsdellP. Oxidant stress stimulates anion secretion from the human airway epithelial cell line Calu-3: implications for cystic fibrosis lung disease. J Physiol, 543:201–209. 2002.
59.
CurranME, SplawskiI, TimothyKW, VincentGM, GreenED, KeatingMT. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell, 80:795–803. 1995.
60.
de JongJW, van der MeerP, NieukoopAS, HuizerT, StroeveRJ, BosE. Xanthine oxidoreductase activity in perfused hearts of various species, including humans. Circ Res, 67:770–773. 1990.
61.
De WindtLJ, LimHW, HaqS, ForceT, MolkentinJD. Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways. J Biol Chem, 275:13571–13579. 2000.
62.
del RioLA, SandalioLM, PalmaJM, BuenoP, CorpasFJ. Metabolism of oxygen radicals in peroxisomes and cellular implications. Free Radic Biol Med, 13:557–580. 1992.
DupratF, GuillemareE, RomeyG, FinkM, LesageF, LazdunskiM, HonoreE. Susceptibility of cloned K+ channels to reactive oxygen species. Proc Natl Acad Sci U S A, 92:11796–11800. 1995.
67.
EagerKR, DulhuntyAF. Activation of the cardiac ryanodine receptor by sulfhydryl oxidation is modified by Mg2+ and ATP. J Membr Biol, 163:9–18. 1998.
68.
EdwardsG, IbbotsonT, WestonAH. Levcromakalim may induce a voltage-independent K-current in rat portal veins by modifying the gating properties of the delayed rectifier. Br J Pharmacol, 110:1037–1048. 1993.
69.
EdwardsG, WestonAH. Induction of a glibenclamide-sensitive K-current by modification of a delayed rectifier channel in rat portal vein in insulinoma cells. Br J Pharmacol, 110:1280–1281. 1993.
70.
EigelBN, GursahaniH, HadleyRW. ROS are required for rapid reactivation of Na+/Ca2+ exchanger in hypoxic reoxygenated guinea pig ventricular myocytes. Am J Physiol Heart Circ Physiol, 286:H955–H963. 2004.
71.
ElliottSJ, DoanTN, HenschkePN. Reductant substrate for glutathione peroxidase modulates oxidant inhibition of Ca2+ signaling in endothelial cells. Am J Physiol, 268:H278–H287. 1995.
72.
ElmoselhiAB, SamsonSE, GroverAK. SR Ca2+ pump heterogeneity in coronary artery: free radicals and IP3-sensitive and -insensitive pools. Am J Physiol, 271:C1652–C1659. 1996.
73.
EricksonJR, JoinerML, GuanX, KutschkeW, YangJ, OddisCV, BartlettRK, LoweJS, O'DonnellSE, Aykin-BurnsN, ZimmermanMC, ZimmermanK, HamAJ, WeissRM, SpitzDR, SheaMA, ColbranRJ, MohlerPJ, AndersonME. A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell, 133:462–474. 2008.
74.
ErxlebenC, LiaoY, GentileS, ChinD, Gomez-AlegriaC, MoriY, BirnbaumerL, ArmstrongDL. Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices. Proc Natl Acad Sci U S A, 103:3932–3937. 2006.
75.
FearonIM. OxLDL enhances L-type Ca2+ currents via lysophosphatidylcholine-induced mitochondrial reactive oxygen species (ROS) production. Cardiovasc Res, 69:855–864. 2006.
76.
FearonIM, PalmerAC, BalmforthAJ, BallSG, VaradiG, PeersC. Hypoxic and redox inhibition of the human cardiac L-type Ca2+ channel. Adv Exp Med Biol, 475:209–218. 2000.
77.
FearonIM, VaradiG, KochS, IsaacsohnI, BallSG, PeersC. Splice variants reveal the region involved in oxygen sensing by recombinant human L-type Ca(2+) channels. Circ Res, 87:537–539. 2000.
78.
FellnerSK, ParkerL. Endothelin-1, superoxide and adeninediphosphate ribose cyclase in shark vascular smooth muscle. J Exp Biol, 208:1045–1052. 2005.
FischbachPS, WhiteA, BarrettTD, LucchesiBR. Risk of ventricular proarrhythmia with selective opening of the myocardial sarcolemmal versus mitochondrial ATP-gated potassium channel. J Pharmacol Exp Ther, 309:554–559. 2004.
81.
FossetM, Schmid-AntomarchiH, de WeilleJR, LazdunskiM. Somatostatin activates glibenclamide-sensitive and ATP-regulated K+ channels in insulinoma cells via a G-protein. FEBS Lett, 242:94–96. 1988.
82.
FrohnwieserB, ChenLQ, SchreibmayerW, KallenRG. Modulation of the human cardiac sodium channel alpha-subunit by cAMP-dependent protein kinase and the responsible sequence domain. J Physiol, 498,Pt 2:309–318. 1997.
GamperN, ZaikaO, LiY, MartinP, HernandezCC, PerezMR, WangAY, JaffeDB, ShapiroMS. Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencing. EMBO J, 25:4996–5004. 2006.
85.
GaoG, OllingerK, BrunkUT. Influence of intracellular glutathione concentration of lipofuscin accumulation in cultured neonatal rat cardiac myocytes. Free Radic Biol Med, 16:187–194. 1994.
86.
GaoT, YataniA, Dell'AcquaML, SakoH, GreenSA, DascalN, ScottJD, HoseyMM. cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron, 19:185–196. 1997.
87.
GarlidKD, CostaAD, QuinlanCL, PierreSV, Dos SantosP. Cardioprotective signaling to mitochondria. J Mol Cell Cardiol, 46:858–866. 2009.
88.
GellensME, GeorgeALJr., ChenLQ, ChahineM, HornR, BarchiRL, KallenRG. Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. Proc Natl Acad Sci U S A, 89:554–558. 1992.
89.
GenW, TaniM, TakeshitaJ, EbiharaY, TamakiK. Mechanisms of Ca2+ overload induced by extracellular H2O2 in quiescent isolated rat cardiomyocytes. Basic Res Cardiol, 96:623–629. 2001.
90.
GoldhaberJI. Free radicals enhance Na+/Ca2+ exchange in ventricular myocytes. Am J Physiol, 271:H823–833. 1996.
91.
GoldhaberJI, JiS, LampST, WeissJN. Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle. Implications for ischemia and reperfusion injury. J Clin Invest, 83:1800–1809. 1989.
92.
GonzalezDR, BeigiF, TreuerAV, HareJM. Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes. Proc Natl Acad Sci U S A, 104:20612–20617. 2007.
93.
GonzalezDR, TreuerAV, CastellanosJ, DulceRA, HareJM. Impaired S-nitrosylation of the ryanodine receptor caused by xanthine oxidase activity contributes to calcium leak in heart failure. J Biol Chem, 285:28938–28945. 2010.
94.
GrantAO. Cardiac ion channels. Circ Arrhythm Electrophysiol, 2:185–194. 2009.
95.
GrossGJ, PeartJN. KATP channels and myocardial preconditioning: an update. Am J Physiol Heart Circ Physiol, 285:H921–930. 2003.
96.
GroverAK, SamsonSE, MisquittaCM. Sarco(endo)plasmic reticulum Ca2+ pump isoform SERCA3 is more resistant than SERCA2b to peroxide. Am J Physiol, 273:C420–C425. 1997.
97.
GyorkeI, HesterN, JonesLR, GyorkeS. The role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calcium. Biophys J, 86:2121–2128. 2004.
98.
HaasM, AskariA, XieZ. Involvement of Src and epidermal growth factor receptor in the signal-transducing function of Na+/K+-ATPase. J Biol Chem, 275:27832–27837. 2000.
99.
HammarstromAK, GagePW. Nitric oxide increases persistent sodium current in rat hippocampal neurons. J Physiol, 520,Pt 2:451–461. 1999.
100.
HammerschmidtS, WahnH. The effect of the oxidant hypochlorous acid on the L-type calcium current in isolated ventricular cardiomyocytes. J Mol Cell Cardiol, 30:1855–1867. 1998.
101.
HammesA, Oberdorf-MaassS, RotherT, NethingK, GollnickF, LinzKW, MeyerR, HuK, HanH, GaudronP, ErtlG, HoffmannS, GantenU, VetterR, SchuhK, BenkwitzC, ZimmerHG, NeysesL. Overexpression of the sarcolemmal calcium pump in the myocardium of transgenic rats. Circ Res, 83:877–888. 1998.
102.
HanDY, MinobeE, WangWY, GuoF, XuJJ, HaoLY, KameyamaM. Calmodulin- and Ca2+-dependent facilitation and inactivation of the Cav1.2 Ca2+ channels in guinea-pig ventricular myocytes. J Pharmacol Sci, 112:310–319. 2010.
103.
HanF, BossuytJ, DespaS, TuckerAL, BersDM. Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes. Circ Res, 99:1376–1383. 2006.
104.
HartJD, DulhuntyAF. Nitric oxide activates or inhibits skeletal muscle ryanodine receptors depending on its concentration, membrane potential and ligand binding. J Membr Biol, 173:227–236. 2000.
105.
HearseDJ, KusamaY, BernierM. Rapid electrophysiological changes leading to arrhythmias in the aerobic rat heart. Photosensitization studies with rose bengal-derived reactive oxygen intermediates. Circ Res, 65:146–153. 1989.
106.
HeinenA, AldakkakM, StoweDF, RhodesSS, RiessML, VaradarajanSG, CamaraAK. Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels. Am J Physiol Heart Circ Physiol, 293:H1400–H1407. 2007.
107.
HenschkePN, ElliottSJ. Oxidized glutathione decreases luminal Ca2+ content of the endothelial cell ins(1,4,5)P3-sensitive Ca2+ store. Biochem J, 312,Pt 2:485–489. 1995.
108.
HerreroA, BarjaG. Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria. J Bioenerg Biomembr, 32:609–615. 2000.
109.
HicksMN, CobbeSM. Effect of glibenclamide on extracellular potassium accumulation and the electrophysiological changes during myocardial ischaemia in the arterially perfused interventricular septum of rabbit. Cardiovasc Res, 25:407–413. 1991.
110.
HiroseM, StuyversBD, DunW, ter KeursHE, BoydenPA. Function of Ca(2+) release channels in Purkinje cells that survive in the infarcted canine heart: a mechanism for triggered Purkinje ectopy. Circ Arrhythm Electrophysiol, 1:387–395. 2008.
111.
HoHT, StevensSC, TerentyevaR, CarnesCA, TerentyevD, GyorkeS. Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors. J Physiol, 589:4697–4708. 2011.
112.
HolmesTC, FadoolDA, RenR, LevitanIB. Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain. Science, 274:2089–2091. 1996.
113.
HoolLC. Hypoxia increases the sensitivity of the L-type Ca(2+) current to beta-adrenergic receptor stimulation via a C2 region-containing protein kinase C isoform. Circ Res, 87:1164–1171. 2000.
114.
HoolLC. What cardiologists should know about calcium ion channels and their regulation by reactive oxygen species. Heart Lung Circ, 16:361–372. 2007.
115.
HoolLC, ArthurPG. Decreasing cellular hydrogen peroxide with catalase mimics the effects of hypoxia on the sensitivity of the L-type Ca2+ channel to beta-adrenergic receptor stimulation in cardiac myocytes. Circ Res, 91:601–609. 2002.
116.
HuH, ChiamvimonvatN, YamagishiT, MarbanE. Direct inhibition of expressed cardiac L-type Ca2+ channels by S-nitrosothiol nitric oxide donors. Circ Res, 81:742–752. 1997.
117.
HudasekK, BrownST, FearonIM. H2O2 regulates recombinant Ca2+ channel alpha1C subunits but does not mediate their sensitivity to acute hypoxia. Biochem Biophys Res Commun, 318:135–141. 2004.
118.
HuhnR, HeinenA, WeberNC, SchlackW, PreckelB, HollmannMW. Ischaemic and morphine-induced post-conditioning: impact of mK(Ca) channels. Br J Anaesth, 105:589–595. 2010.
119.
HumphriesKM, DealMS, TaylorSS. Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification. J Biol Chem, 280:2750–2758. 2005.
120.
HundTJ, RudyY. A role for calcium/calmodulin-dependent protein kinase II in cardiac disease and arrhythmia. Handb Exp Pharmacol, 201–220. 2006.
121.
HundTJ, ZimanAP, LedererWJ, MohlerPJ. The cardiac IP3 receptor: uncovering the role of “the other” calcium-release channel. J Mol Cell Cardiol, 45:159–161. 2008.
122.
IbbotsonT, EdwardsG, NoackT, WestonAH. Effects of P1060 and aprikalim on whole-cell currents in rat portal vein; inhibition by glibenclamide and phentolamine. Br J Pharmacol, 108:991–998. 1993.
123.
IchinariK, KakeiM, MatsuokaT, NakashimaH, TanakaH. Direct activation of the ATP-sensitive potassium channel by oxygen free radicals in guinea-pig ventricular cells: its potentiation by MgADP. J Mol Cell Cardiol, 28:1867–1877. 1996.
124.
InoueI, NagaseH, KishiK, HigutiT. ATP-sensitive K+ channel in the mitochondrial inner membrane. Nature, 352:244–247. 1991.
125.
IribeG, JinH, KaiharaK, NaruseK. Effects of axial stretch on sarcolemmal BKCa channels in post-hatch chick ventricular myocytes. Exp Physiol, 95:699–711. 2010.
126.
JabrRI, ColeWC. Alterations in electrical activity and membrane currents induced by intracellular oxygen-derived free radical stress in guinea pig ventricular myocytes. Circ Res, 72:1229–1244. 1993.
127.
JiangMT, NakaeY, LjubkovicM, KwokWM, StoweDF, BosnjakZJ. Isoflurane activates human cardiac mitochondrial adenosine triphosphate-sensitive K+ channels reconstituted in lipid bilayers. Anesth Analg, 105:926–932table of contents2007.
128.
JornotL, MaechlerP, WollheimCB, JunodAF. Reactive oxygen metabolites increase mitochondrial calcium in endothelial cells: implication of the Ca2+/Na+ exchanger. J Cell Sci, 112,Pt 7:1013–1022. 1999.
129.
JosephsonRA, SilvermanHS, LakattaEG, SternMD, ZweierJL. Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes. J Biol Chem, 266:2354–2361. 1991.
130.
JudeS, BedutS, RogerS, PinaultM, ChamperouxP, WhiteE, Le GuennecJY. Peroxidation of docosahexaenoic acid is responsible for its effects on I TO and I SS in rat ventricular myocytes. Br J Pharmacol, 139:816–822. 2003.
131.
JungC, MartinsAS, NiggliE, ShirokovaN. Dystrophic cardiomyopathy: amplification of cellular damage by Ca2+ signalling and reactive oxygen species-generating pathways. Cardiovasc Res, 77:766–773. 2008.
132.
KaganV, SerbinovaE, PackerL. Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling. Biochem Biophys Res Commun, 169:851–857. 1990.
133.
KarleCA, ZitronE, ZhangW, Wendt-NordahlG, KathoferS, ThomasD, GutB, ScholzE, VahlCF, KatusHA, KiehnJ. Human cardiac inwardly-rectifying K+ channel Kir(2.1b) is inhibited by direct protein kinase C-dependent regulation in human isolated cardiomyocytes and in an expression system. Circulation, 106:1493–1499. 2002.
134.
KawakamiM, OkabeE. Superoxide anion radical-triggered Ca2+ release from cardiac sarcoplasmic reticulum through ryanodine receptor Ca2+ channel. Mol Pharmacol, 53:497–503. 1998.
135.
KevinLG, NovalijaE, StoweDF. Reactive oxygen species as mediators of cardiac injury and protection: the relevance to anesthesia practice. Anesth Analg, 101:1275–1287. 2005.
136.
KimuraJ, OnoT, SakamotoK, ItoE, WatanabeS, MaedaS, ShikamaY, YatabeMS, MatsuokaI. Na+-Ca2+ exchanger expression and its modulation. Biol Pharm Bull, 32:325–331. 2009.
137.
KitakazeM, NodeK, KomamuraK, MinaminoT, InoueM, HoriM, KamadaT. Evidence for nitric oxide generation in the cardiomyocytes: its augmentation by hypoxia. J Mol Cell Cardiol, 27:2149–2154. 1995.
KohlhaasM, MaackC. Adverse bioenergetic consequences of na+-Ca2+ exchanger-mediated Ca2+ influx in cardiac myocytes. Circulation, 122:2273–2280. 2010.
141.
KolbeK, SchonherrR, GessnerG, SahooN, HoshiT, HeinemannSH. Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels. J Physiol, 588:2999–3009. 2010.
142.
KometianiP, LiJ, GnudiL, KahnBB, AskariA, XieZ. Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases. J Biol Chem, 273:15249–15256. 1998.
143.
KonyaL, KekesiV, Juhasz-NagyS, FeherJ. The effect of superoxide dismutase in the myocardium during reperfusion in the dog. Free Radic Biol Med, 13:527–532. 1992.
144.
KorgeP, PingP, WeissJN. Reactive oxygen species production in energized cardiac mitochondria during hypoxia/reoxygenation: modulation by nitric oxide. Circ Res, 103:873–880. 2008.
145.
KoshlandDEJr. The molecule of the year. Science, 258:1861. 1992.
146.
KourieJI. Interaction of reactive oxygen species with ion transport mechanisms. Am J Physiol, 275:C1–C24. 1998.
147.
KukrejaRC, HessML. The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection. Cardiovasc Res, 26:641–655. 1992.
148.
KuoSS, SaadAH, KoongAC, HahnGM, GiacciaAJ. Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells. Proc Natl Acad Sci U S A, 90:908–912. 1993.
149.
KusterGM, LancelS, ZhangJ, CommunalC, TrucilloMP, LimCC, PfisterO, WeinbergEO, CohenRA, LiaoR, SiwikDA, ColucciWS. Redox-mediated reciprocal regulation of SERCA and Na+-Ca2+ exchanger contributes to sarcoplasmic reticulum Ca2+ depletion in cardiac myocytes. Free Radic Biol Med, 48:1182–1187. 2010.
150.
LacampagneA, DuittozA, BolanosP, PeineauN, ArgibayJA. Effect of sulfhydryl oxidation on ionic and gating currents associated with L-type calcium channels in isolated guinea-pig ventricular myocytes. Cardiovasc Res, 30:799–806. 1995.
151.
LacerdaAE, RampeD, BrownAM. Effects of protein kinase C activators on cardiac Ca2+ channels. Nature, 335:249–251. 1988.
LiGR, FengJ, WangZ, FerminiB, NattelS. Adrenergic modulation of ultrarapid delayed rectifier K+ current in human atrial myocytes. Circ Res, 78:903–915. 1996.
157.
LiN, TimofeyevV, TutejaD, XuD, LuL, ZhangQ, ZhangZ, SingapuriA, AlbertTR, RajagopalAV, BondCT, PeriasamyM, AdelmanJ, ChiamvimonvatN. Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation. J Physiol, 587:1087–1100. 2009.
158.
LiS, LiX, LiYL, ShaoCH, BidaseeKR, RozanskiGJ. Insulin regulation of glutathione and contractile phenotype in diabetic rat ventricular myocytes. Am J Physiol Heart Circ Physiol, 292:H1619–H1629. 2007.
159.
LiX, TangK, XieB, LiS, RozanskiGJ. Regulation of Kv4 channel expression in failing rat heart by the thioredoxin system. Am J Physiol Heart Circ Physiol, 295:H416–H424. 2008.
160.
LiangH, LiX, LiS, ZhengMQ, RozanskiGJ. Oxidoreductase regulation of Kv currents in rat ventricle. J Mol Cell Cardiol, 44:1062–1071. 2008.
161.
LippP, LaineM, ToveySC, BurrellKM, BerridgeMJ, LiW, BootmanMD. Functional InsP3 receptors that may modulate excitation-contraction coupling in the heart. Curr Biol, 10:939–942. 2000.
162.
LiuG, AbramsonJJ, ZableAC, PessahIN. Direct evidence for the existence and functional role of hyperreactive sulfhydryls on the ryanodine receptor-triadin complex selectively labeled by the coumarin maleimide 7-diethylamino-3-(4′-maleimidylphenyl)-4-methylcoumarin. Mol Pharmacol, 45:189–200. 1994.
163.
LiuM, LiuH, DudleySCJr. Reactive oxygen species originating from mitochondria regulate the cardiac sodium channel. Circ Res, 107:967–974. 2010.
164.
LiuY, FiskumG, SchubertD. Generation of reactive oxygen species by the mitochondrial electron transport chain. J Neurochem, 80:780–787. 2002.
MaJH, LuoAT, ZhangPH. Effect of hydrogen peroxide on persistent sodium current in guinea pig ventricular myocytes. Acta Pharmacol Sin, 26:828–834. 2005.
168.
MaJH, WangXP, ZhangPH. [Nitric oxide increases persistent sodium current of ventricular myocytes in guinea pig during normoxia and hypoxia]Sheng Li Xue Bao, 56:603–608. 2004.
169.
MacdonaldWA, HoolLC. The effect of acute hypoxia on excitability in the heart and the L-type calcium channel as a therapeutic target. Curr Drug Discov Technol, 5:302–311. 2008.
170.
MacFarlaneNG, MillerDJ. Effects of the reactive oxygen species hypochlorous acid and hydrogen peroxide on force production and calcium sensitivity of rat cardiac myofilaments. Pflugers Arch, 428:561–568. 1994.
171.
MacMickingJD, NathanC, HomG, ChartrainN, FletcherDS, TrumbauerM, StevensK, XieQW, SokolK, HutchinsonNet al.Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell, 81:641–650. 1995.
172.
MahajanA, SatoD, ShiferawY, BaherA, XieLH, PeraltaR, OlceseR, GarfinkelA, QuZ, WeissJN. Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics. Biophys J, 94:411–423. 2008.
173.
MaierLS, BersDM. Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res, 73:631–640. 2007.
174.
MaierSK, WestenbroekRE, McCormickKA, CurtisR, ScheuerT, CatterallWA. Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart. Circulation, 109:1421–1427. 2004.
175.
MakitaN, Sloan-BrownK, WeghuisDO, RopersHH, GeorgeALJr. Genomic organization and chromosomal assignment of the human voltage-gated Na+ channel beta 1 subunit gene (SCN1B)Genomics, 23:628–634. 1994.
176.
MandelkerL. Introduction to oxidative stress and mitochondrial dysfunction. Vet Clin North Am Small Anim Pract, 38:1–30v2008.
MarxSO, KurokawaJ, ReikenS, MotoikeH, D'ArmientoJ, MarksAR, KassRS. Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science, 295:496–499. 2002.
179.
MasellaR, Di BenedettoR, VariR, FilesiC, GiovanniniC. Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J Nutr Biochem, 16:577–586. 2005.
180.
MatsudaH, NomaA, KurachiY, IrisawaH. Transient depolarization and spontaneous voltage fluctuations in isolated single cells from guinea pig ventricles. Calcium-mediated membrane potential fluctuations. Circ Res, 51:142–151. 1982.
181.
MatsuuraH, ShattockMJ. Effects of oxidant stress on steady-state background currents in isolated ventricular myocytes. Am J Physiol, 261:H1358–H1365. 1991.
182.
MatsuuraH, ShattockMJ. Membrane potential fluctuations and transient inward currents induced by reactive oxygen intermediates in isolated rabbit ventricular cells. Circ Res, 68:319–329. 1991.
183.
MatsuzakiS, SzwedaPA, SzwedaLI, HumphriesKM. Regulated production of free radicals by the mitochondrial electron transport chain: Cardiac ischemic preconditioning. Adv Drug Deliv Rev, 61:1324–1331. 2009.
184.
McCordJM, FridovichI. Superoxide dismutase: the first twenty years (1968–1988)Free Radic Biol Med, 5:363–369. 1988.
MishraS, UndrovinasNA, MaltsevVA, ReznikovV, SabbahHN, UndrovinasA. Post-transcriptional silencing of SCN1B and SCN2B genes modulates late sodium current in cardiac myocytes from normal dogs and dogs with chronic heart failure. Am J Physiol Heart Circ Physiol, 301:H1596–H1605. 2011.
187.
MittalCK, MuradF. Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical: a physiological regulator of guanosine 3′,5′-monophosphate formation. Proc Natl Acad Sci U S A, 74:4360–4364. 1977.
188.
MiuraT, LiuY, KitaH, OgawaT, ShimamotoK. Roles of mitochondrial ATP-sensitive K channels and PKC in anti-infarct tolerance afforded by adenosine A1 receptor activation. J Am Coll Cardiol, 35:238–245. 2000.
189.
MohammadiK, KometianiP, XieZ, AskariA. Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2. J Biol Chem, 276:42050–42056. 2001.
190.
MohlerPJ, DavisJQ, BennettV. Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain. PLoS Biol, 3:e423. 2005.
MurphyMP. How mitochondria produce reactive oxygen species. Biochem J, 417:1–13. 2009.
196.
MurrayKT, FahrigSA, DealKK, PoSS, HuNN, SnydersDJ, TamkunMM, BennettPB. Modulation of an inactivating human cardiac K+ channel by protein kinase C. Circ Res, 75:999–1005. 1994.
NakamuraTY, CoetzeeWA, Vega-Saenz De MieraE, ArtmanM, RudyB. Modulation of Kv4 channels, key components of rat ventricular transient outward K+ current, by PKC. Am J Physiol, 273:H1775–1786. 1997.
199.
NakayaH, TakedaY, TohseN, KannoM. Mechanism of the membrane depolarization induced by oxidative stress in guinea-pig ventricular cells. J Mol Cell Cardiol, 24:523–534. 1992.
200.
NakayaH, TohseN, KannoM. Electrophysiological derangements induced by lipid peroxidation in cardiac tissue. Am J Physiol, 253:H1089–H1097. 1987.
201.
NanC, LiY, Jean-CharlesPY, ChenG, KreymermanA, PrenticeH, WeissbachH, HuangX. Deficiency of methionine sulfoxide reductase A causes cellular dysfunction and mitochondrial damage in cardiac myocytes under physical and oxidative stresses. Biochem Biophys Res Commun, 402:608–613. 2010.
202.
NanduriJ, WangN, BergsonP, YuanG, FickerE, PrabhakarNR. Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein. Biochem Biophys Res Commun, 373:309–314. 2008.
203.
NapoliC, de NigrisF, PalinskiW. Multiple role of reactive oxygen species in the arterial wall. J Cell Biochem, 82:674–682. 2001.
NetticadanT, KatoK, TappiaP, ElimbanV, DhallaNS. Phosphorylation of cardiac Na+-K+ ATPase by Ca2+/calmodulin dependent protein kinase. Biochem Biophys Res Commun, 238:544–548. 1997.
206.
NomaA. ATP-regulated K+ channels in cardiac muscle. Nature, 305:147–148. 1983.
207.
O'RourkeB, RamzaBM, MarbanE. Oscillations of membrane current and excitability driven by metabolic oscillations in heart cells. Science, 265:962–966. 1994.
208.
ObaT, KoshitaM, YamaguchiM. H2O2 modulates twitch tension and increases Po of Ca2+ release channel in frog skeletal muscle. Am J Physiol, 271:C810–818. 1996.
209.
OgimotoG, YudowskiGA, BarkerCJ, KohlerM, KatzAI, FerailleE, PedemonteCH, BerggrenPO, BertorelloAM. G protein-coupled receptors regulate Na+, K+-ATPase activity and endocytosis by modulating the recruitment of adaptor protein 2 and clathrin. Proc Natl Acad Sci U S A, 97:3242–3247. 2000.
210.
OlsonTM, TerzicA. Human K(ATP) channelopathies: diseases of metabolic homeostasis. Pflugers Arch, 460:295–306. 2010.
211.
PallandiRT, PerryMA, CampbellTJ. Proarrhythmic effects of an oxygen-derived free radical generating system on action potentials recorded from guinea pig ventricular myocardium: a possible cause of reperfusion-induced arrhythmias. Circ Res, 61:50–54. 1987.
212.
PalmerRM, FerrigeAG, MoncadaS. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature, 327:524–526. 1987.
213.
PannaccioneA, CastaldoP, FickerE, AnnunziatoL, TaglialatelaM. Histidines 578 and 587 in the S5–S6 linker of the human Ether-a-gogo Related Gene-1 K+ channels confer sensitivity to reactive oxygen species. J Biol Chem, 277:8912–8919. 2002.
214.
PastoreA, FedericiG, BertiniE, PiemonteF. Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta, 333:19–39. 2003.
215.
PerierC, TieuK, GueganC, CaspersenC, Jackson-LewisV, CarelliV, MartinuzziA, HiranoM, PrzedborskiS, VilaM. Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage. Proc Natl Acad Sci U S A, 102:19126–19131. 2005.
QuY, RogersJC, TanadaTN, CatterallWA, ScheuerT. Phosphorylation of S1505 in the cardiac Na+ channel inactivation gate is required for modulation by protein kinase C. J Gen Physiol, 108:375–379. 1996.
218.
RahaS, McEachernGE, MyintAT, RobinsonBH. Superoxides from mitochondrial complex III: the role of manganese superoxide dismutase. Free Radic Biol Med, 29:170–180. 2000.
219.
ReevesJP, BaileyCA, HaleCC. Redox modification of sodium-calcium exchange activity in cardiac sarcolemmal vesicles. J Biol Chem, 261:4948–4955. 1986.
220.
ReidMB, KhawliFA, MoodyMR. Reactive oxygen in skeletal muscle. III. Contractility of unfatigued muscle. J Appl Physiol, 75:1081–1087. 1993.
RomashkoDN, MarbanE, O'RourkeB. Subcellular metabolic transients and mitochondrial redox waves in heart cells. Proc Natl Acad Sci U S A, 95:1618–1623. 1998.
223.
Ruiz PetrichE, LeblancN, deLorenziF, AllardY, SchanneOF. Effects of K+ channel blockers on the action potential of hypoxic rabbit myocardium. Br J Pharmacol, 106:924–930. 1992.
224.
RyuSY, LeeSH, HoWK. Generation of metabolic oscillations by mitoKATP and ATP synthase during simulated ischemia in ventricular myocytes. J Mol Cell Cardiol, 39:874–881. 2005.
225.
SabriA, HughieHH, LucchesiPA. Regulation of hypertrophic and apoptotic signaling pathways by reactive oxygen species in cardiac myocytes. Antioxid Redox Signal, 5:731–740. 2003.
226.
SaintDA. The cardiac persistent sodium current: an appealing therapeutic target?Br J Pharmacol, 153:1133–1142. 2008.
227.
SanchezG, EscobarM, PedrozoZ, MachoP, DomenechR, HartelS, HidalgoC, DonosoP. Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible role in cardioprotection. Cardiovasc Res, 77:380–386. 2008.
228.
SatohH. Depression of the spontaneous activity by phorbol esters in young embryonic chick cardiomyocytes. Jpn J Pharmacol, 67:297–304. 1995.
229.
SchererNM, DeamerDW. Oxidative stress impairs the function of sarcoplasmic reticulum by oxidation of sulfhydryl groups in the Ca2+-ATPase. Arch Biochem Biophys, 246:589–601. 1986.
230.
SchonherrR, HeinemannSH. Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel. J Physiol, 493,Pt 3:635–642. 1996.
231.
SchottJJ, AlshinawiC, KyndtF, ProbstV, HoorntjeTM, HulsbeekM, WildeAA, EscandeD, MannensMM, Le MarecH. Cardiac conduction defects associate with mutations in SCN5A. Nat Genet, 23:20–21. 1999.
232.
ShigekawaM, KatanosakaY, WakabayashiS. Regulation of the cardiac Na+/Ca2+ exchanger by calcineurin and protein kinase C. Ann N Y Acad Sci, 1099:53–63. 2007.
233.
SigalasC, Mayo-MartinMB, JaneDE, SitsapesanR. Ca2+-calmodulin increases RyR2 open probability yet reduces ryanoid association with RyR2. Biophys J, 97:1907–1916. 2009.
234.
SlodzinskiMK, AonMA, O'RourkeB. Glutathione oxidation as a trigger of mitochondrial depolarization and oscillation in intact hearts. J Mol Cell Cardiol, 45:650–660. 2008.
235.
SmaniT, Calderon-SanchezE, Gomez-HurtadoN, Fernandez-VelascoM, CachofeiroV, LaheraV, OrdonezA, DelgadoC. Mechanisms underlying the activation of L-type calcium channels by urocortin in rat ventricular myocytes. Cardiovasc Res, 87:459–466. 2010.
236.
SmithRA, KelsoGF, BlaikieFH, PorteousCM, LedgerwoodEC, HughesG, JamesAM, RossMF, Asin-CayuelaJ, CochemeHM, FilipovskaA, MurphyMP. Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences. Biochem Soc Trans, 31:1295–1299. 2003.
237.
SongY, ShryockJC, BelardinelliL. A slowly inactivating sodium current contributes to spontaneous diastolic depolarization of atrial myocytes. Am J Physiol Heart Circ Physiol, 297:H1254–H1262. 2009.
238.
SongY, ShryockJC, WagnerS, MaierLS, BelardinelliL. Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction. J Pharmacol Exp Ther, 318:214–222. 2006.
239.
SongYH, ChoH, RyuSY, YoonJY, ParkSH, NohCI, LeeSH, HoWK. L-type Ca(2+) channel facilitation mediated by H(2)O(2)-induced activation of CaMKII in rat ventricular myocytes. J Mol Cell Cardiol, 48:773–780. 2010.
240.
SplawskiI, TimothyKW, DecherN, KumarP, SachseFB, BeggsAH, SanguinettiMC, KeatingMT. Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Proc Natl Acad Sci U S A, 102:8089–8096discussion 8086–80882005.
241.
St-PierreJ, BuckinghamJA, RoebuckSJ, BrandMD. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem, 277:44784–44790. 2002.
StrehlerEE, ZachariasDA. Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. Physiol Rev, 81:21–50. 2001.
244.
TaglialatelaM, CastaldoP, IossaS, PannaccioneA, FresiA, FickerE, AnnunziatoL. Regulation of the human ether-a-gogo related gene (HERG) K+ channels by reactive oxygen species. Proc Natl Acad Sci U S A, 94:11698–11703. 1997.
TanHL, KupershmidtS, ZhangR, StepanovicS, RodenDM, WildeAA, AndersonME, BalserJR. A calcium sensor in the sodium channel modulates cardiac excitability. Nature, 415:442–447. 2002.
247.
TarrM, ArriagaE, GoertzKK, ValenzenoDP. Properties of cardiac I(leak) induced by photosensitizer-generated reactive oxygen. Free Radic Biol Med, 16:477–484. 1994.
248.
TelezhkinV, BrazierSP, CayzacSH, WilkinsonWJ, RiccardiD, KempPJ. Mechanism of inhibition by hydrogen sulfide of native and recombinant BKCa channels. Respir Physiol Neurobiol, 172:169–178. 2010.
249.
ThomasGP, SimsSM, CookMA, KarmazynM. Hydrogen peroxide-induced stimulation of L-type calcium current in guinea pig ventricular myocytes and its inhibition by adenosine A1 receptor activation. J Pharmacol Exp Ther, 286:1208–1214. 1998.
250.
TokubeK, KiyosueT, AritaM. Effects of hydroxyl radicals on KATP channels in guinea-pig ventricular myocytes. Pflugers Arch, 437:155–157. 1998.
251.
TsaiCT, WangDL, ChenWP, HwangJJ, HsiehCS, HsuKL, TsengCD, LaiLP, TsengYZ, ChiangFT, LinJL. Angiotensin II increases expression of alpha1C subunit of L-type calcium channel through a reactive oxygen species and cAMP response element-binding protein-dependent pathway in HL-1 myocytes. Circ Res, 100:1476–1485. 2007.
252.
TutejaD, RafizadehS, TimofeyevV, WangS, ZhangZ, LiN, MateoRK, SingapuriA, YoungJN, KnowltonAA, ChiamvimonvatN. Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels. Circ Res, 107:851–859. 2010.
253.
UedaK, ValdiviaC, Medeiros-DomingoA, TesterDJ, VattaM, FarrugiaG, AckermanMJ, MakielskiJC. Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex. Proc Natl Acad Sci U S A, 105:9355–9360. 2008.
254.
VajdaS, BaczkoI, LepranI. Selective cardiac plasma-membrane K(ATP) channel inhibition is defibrillatory and improves survival during acute myocardial ischemia and reperfusion. Eur J Pharmacol, 577:115–123. 2007.
255.
ValkoM, LeibfritzD, MoncolJ, CroninMT, MazurM, TelserJ. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol, 39:44–84. 2007.
256.
Vega-Saenz de MieraE, RudyB. Modulation of K+ channels by hydrogen peroxide. Biochem Biophys Res Commun, 186:1681–1687. 1992.
257.
ViolaHM, ArthurPG, HoolLC. Transient exposure to hydrogen peroxide causes an increase in mitochondria-derived superoxide as a result of sustained alteration in L-type Ca2+ channel function in the absence of apoptosis in ventricular myocytes. Circ Res, 100:1036–1044. 2007.
258.
WagnerHH, UlbrichtW. The rates of saxitoxin action and of saxitoxin-tetrodotoxin interaction at the node of Ranvier. Pflugers Arch, 359:297–315. 1975.
WagnerS, RuffHM, WeberSL, BellmannS, SowaT, SchulteT, AndersonME, GrandiE, BersDM, BacksJ, BelardinelliL, MaierLS. Reactive oxygen species-activated Ca/calmodulin kinase IIdelta is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res, 108:555–565. 2011.
261.
WangQ, ShenJ, SplawskiI, AtkinsonD, LiZ, RobinsonJL, MossAJ, TowbinJA, KeatingMT. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell, 80:805–811. 1995.
262.
WangW, MaJ, ZhangP, LuoA. Redox reaction modulates transient and persistent sodium current during hypoxia in guinea pig ventricular myocytes. Pflugers Arch, 454:461–475. 2007.
263.
WardCA, GilesWR. Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes. J Physiol, 500,Pt 3:631–642. 1997.
264.
WestJW, NumannR, MurphyBJ, ScheuerT, CatterallWA. A phosphorylation site in the Na+ channel required for modulation by protein kinase C. Science, 254:866–868. 1991.
265.
WirthKJ, RosensteinB, UhdeJ, EnglertHC, BuschAE, ScholkensBA. ATP-sensitive potassium channel blocker HMR 1883 reduces mortality and ischemia-associated electrocardiographic changes in pigs with coronary occlusion. J Pharmacol Exp Ther, 291:474–481. 1999.
266.
WuX, ChangB, BlairNS, SargentM, YorkAJ, RobbinsJ, ShullGE, MolkentinJD. Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents. J Clin Invest, 119:976–985. 2009.
267.
XiaoYF, GomezAM, MorganJP, LedererWJ, LeafA. Suppression of voltage-gated L-type Ca2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes. Proc Natl Acad Sci U S A, 94:4182–4187. 1997.
268.
XieLH, ChenF, KaragueuzianHS, WeissJN. Oxidative-stress-induced afterdepolarizations and calmodulin kinase II signaling. Circ Res, 104:79–86. 2009.
269.
XieZ, AskariA. Na(+)/K(+)-ATPase as a signal transducer. Eur J Biochem, 269:2434–2439. 2002.
270.
XieZ, Jack-HaysM, WangY, PeriyasamySM, BlancoG, HuangWH, AskariA. Different oxidant sensitivities of the alpha 1 and alpha 2 isoforms of Na+/K(+)-ATPase expressed in baculovirus-infected insect cells. Biochem Biophys Res Commun, 207:155–159. 1995.
271.
XieZ, KometianiP, LiuJ, LiJ, ShapiroJI, AskariA. Intracellular reactive oxygen species mediate the linkage of Na+/K+-ATPase to hypertrophy and its marker genes in cardiac myocytes. J Biol Chem, 274:19323–19328. 1999.
272.
XieZJ, WangYH, AskariA, HuangWH, KlaunigJE. Studies on the specificity of the effects of oxygen metabolites on cardiac sodium pump. J Mol Cell Cardiol, 22:911–920. 1990.
273.
XuKY, ZweierJL, BeckerLC. Oxygen-free radicals directly attack the ATP binding site of the cardiac Na+,K(+)-ATPase. Ann N Y Acad Sci, 834:680–683. 1997.
274.
XuL, EuJP, MeissnerG, StamlerJS. Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. Science, 279:234–237. 1998.
275.
XuW, LiuY, WangS, McDonaldT, Van EykJE, SidorA, O'RourkeB. Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane. Science, 298:1029–1033. 2002.
276.
YamaokaK, YakehiroM, YukiT, FujiiH, SeyamaI. Effect of sulfhydryl reagents on the regulatory system of the L-type Ca channel in frog ventricular myocytes. Pflugers Arch, 440:207–215. 2000.
277.
YanXS, MaJH, ZhangPH. Modulation of K(ATP) currents in rat ventricular myocytes by hypoxia and a redox reaction. Acta Pharmacol Sin, 30:1399–1414. 2009.
278.
YanY, LiuJ, WeiC, LiK, XieW, WangY, ChengH. Bidirectional regulation of Ca2+ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes. Cardiovasc Res, 77:432–441. 2008.
279.
YangL, DoshiD, MorrowJ, KatchmanA, ChenX, MarxSO. Protein kinase C isoforms differentially phosphorylate Ca(v)1.2 alpha(1c)Biochemistry, 48:6674–6683. 2009.
280.
YaoL, FanP, JiangZ, Viatchenko-KarpinskiS, WuY, KornyeyevD, HirakawaR, BudasGR, RajamaniS, ShryockJC, BelardinelliL. Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice. Am J Physiol Cell Physiol, 301:C577–C586. 2011.
281.
YarasN, TuranB. Interpretation of relevance of sodium-calcium exchange in action potential of diabetic rat heart by mathematical model. Mol Cell Biochem, 269:121–129. 2005.
282.
YeB, KrobothSL, PuJL, SimsJJ, AggarwalNT, McNallyEM, MakielskiJC, ShiNQ. Molecular identification and functional characterization of a mitochondrial sulfonylurea receptor 2 splice variant generated by intraexonic splicing. Circ Res, 105:1083–1093. 2009.
283.
YenHC, OberleyTD, VichitbandhaS, HoYS, St ClairDK. The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. J Clin Invest, 98:1253–1260. 1996.
284.
YtrehusK, RotevatnS, LovaasE, SaetersdalT, MjosOD. Mitochondrial calcium in hearts subjected to lipid peroxidation with contracture development. Basic Res Cardiol, 84:646–652. 1989.
285.
YuanP, LeonettiMD, PicoAR, HsiungY, MacKinnonR. Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science, 329:182–186. 2010.
286.
ZableAC, FaveroTG, AbramsonJJ. Glutathione modulates ryanodine receptor from skeletal muscle sarcoplasmic reticulum. Evidence for redox regulation of the Ca2+ release mechanism. J Biol Chem, 272:7069–7077. 1997.
287.
ZahradnikovaA, MinarovicI, VenemaRC, MeszarosLG. Inactivation of the cardiac ryanodine receptor calcium release channel by nitric oxide. Cell Calcium, 22:447–454. 1997.
288.
ZaidiA, FernandesD, BeanJL, MichaelisML. Effects of paraquat-induced oxidative stress on the neuronal plasma membrane Ca(2+)-ATPase. Free Radic Biol Med, 47:1507–1514. 2009.
289.
ZengQ, HanY, BaoY, LiW, LiX, ShenX, WangX, YaoF, O'RourkeST, SunC. 20-HETE increases NADPH oxidase-derived ROS production and stimulates the L-type Ca2+ channel via a PKC-dependent mechanism in cardiomyocytes. Am J Physiol Heart Circ Physiol, 299:H1109–H1117. 2010.
ZhouJ, YiJ, HuN, GeorgeALJr., MurrayKT. Activation of protein kinase A modulates trafficking of the human cardiac sodium channel in Xenopus oocytes. Circ Res, 87:33–38. 2000.
