Novel discoveries in the DNA repair field have lead to continuous and rapid advancement of our understanding of not only DNA repair but also DNA replication and recombination. Research in the field transcends numerous areas of biology, biochemistry, physiology, and medicine, making significant connections across these broad areas of study. From early studies conducted in bacterial systems to current analyses in eukaryotic systems and human disease, the innovative research into the mechanisms of repair machines and the consequences of ineffective DNA repair has impacted a wide scientific community. This Forum contains a select mix of primary research articles in addition to a number of timely reviews covering a subset of DNA repair pathways where recent advances and novel discoveries are improving our understanding of DNA repair, its regulation, and implications to human disease. Antioxid. Redox Signal. 14, 2461–2464.
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References
1.
AndrewsBJ, LehmanJA, TurchiJJ. Kinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complex. J Biol Chem, 281:13596–13603. 2006.
2.
BacsiA, KannanS, LeeMS, HazraTK, BoldoghI. Modulation of DNA-dependent protein kinase activity in chlorambucil-treated cells. Free Radic Biol Med, 39:1650–1659. 2005.
3.
BaumannP, WestSC. DNA end-joining catalyzed by human cell-free extracts. Proc Natl Acad Sci U S A, 95:14066–14070. 1998.
4.
BoeckmanHJ, TregoKS, TurchiJJ. Cisplatin sensitizes cancer cells to ionizing radiation via inhibition of nonhomologous end joining. Mol Cancer Res, 3:277–285. 2005.
5.
BoldoghI, RoyG, LeeMS, BacsiA, HazraTK, BhakatKK, DasGC, MitraS. Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress. Toxicology, 193:137–152. 2003.
6.
BurgerRM. Nature of activated bleomycin. Metal-Oxo Metal-Peroxo Species Catalytic Oxidations, 97:287–303. 2000.
7.
ChouKm. DNA polymerase eta and chemotherapeutic agents. Antioxid Redox Signal, 14:2521–2529. 2011.
8.
ClementFC, KaczmarekN, MathieuN, TomasM, LeitenstorferA, Ferrando-MayE, NaegeliH. Dissection of the Xeroderma Pigmentosum Group C protein function by site-directed mutagenesis. Antioxid Redox Signal, 14:2479–2490. 2011.
DattaK, JarugaP, DizdarogluM, NeumannRD, WintersTA. Molecular analysis of base damage clustering associated with a site-specific radiation-induced DNA double-strand break. Radiat Res, 166:767–781. 2006.
11.
DiggleCP, BentleyJ, KnowlesMA, KiltieAE. Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts. Nucleic Acids Res, 33:2531–2539. 2005.
12.
EarleyJN, TurchiJJ. Interrogation of nucleotide excision repair capacity: impact on platinum-based cancer therapy. Antioxid Redox Signal, 14:2465–2477. 2011.
13.
GoodismanJ, HagrmanD, TackaKA, SouidAK. Analysis of cytotoxicities of platinum compounds. Cancer Chemother Pharmacol, 57:257–267. 2006.
14.
MaoZ, BozzellaM, SeluanovA, GorbunovaV. Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair (Amst), 7:1765–1771. 2008.
15.
PastwaE, NeumannRD, MezhevayaK, WintersTA. Repair of radiation-induced DNA double-strand breaks is dependent upon radiation quality and the structural complexity of double-strand breaks. Radiat Res, 159:251–261. 2003.
16.
PawelczakKS, BennettSM, TurchiJJ. Coordination of DNA–PK activation and nuclease processing of DNA termini in NHEJ. Antioxid Redox Signal, 14:2531–2543. 2011.
17.
PovirkL. DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes. Mutat Res, 355:71–89. 1996.
18.
PrestonTJ, HendersonJT, McCallumGP, WellsPG. Base excision repair of reactive oxygen species-initiated 7,8-dihydro-8-oxo-2'-deoxyguanosine inhibits the cytotoxicity of platinum anticancer drugs. Mol Cancer Ther, 8:2015–2026. 2009.
19.
RamsdenDA. Polymerases in nonhomologous end joining: building a bridge over broken chromosomes. Antioxid Redox Signal, 14:2509–2519. 2011.
20.
SongJY, LimJW, KimH, MorioT, KimKH. Oxidative stress induces nuclear loss of DNA repair proteins Ku70 and Ku80 and apoptosis in pancreatic acinar AR42J cells. J Biol Chem, 278:36676–36687. 2003.
21.
SvilarD, GoellnerEM, AlmeidaKH, SobolRW. Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage. Antioxid Redox Signal, 14:2491–2507. 2011.
22.
WeinstockDM, BrunetE, JasinM. Induction of chromosomal translocations in mouse and human cells using site-specific endonucleases. J Natl Cancer Inst Monogr, 39:20–24. 2008.
