Redox homeostasis governs a number of critical cellular processes. In turn, imbalances in pathways that control oxidative and reductive conditions have been linked to a number of human disease pathologies, particularly those associated with aging. Reduced glutathione is the most prevalent biological thiol and plays a crucial role in maintaining a reduced intracellular environment. Exposure to reactive oxygen or nitrogen species is causatively linked to the disease pathologies associated with redox imbalance. In particular, reactive oxygen species can differentially oxidize certain cysteine residues in target proteins and the reversible process of S-glutathionylation may mitigate or mediate the damage. This post-translational modification adds a tripeptide and a net negative charge that can lead to distinct structural and functional changes in the target protein. Because it is reversible, S-glutathionylation has the potential to act as a biological switch and to be integral in a number of critical oxidative signaling events. The present review provides a comprehensive account of how the S-glutathionylation cycle influences protein structure/function and cellular regulatory events, and how these may impact on human diseases. By understanding the components of this cycle, there should be opportunities to intervene in stress- and aging-related pathologies, perhaps through prevention and diagnostic and therapeutic platforms. Antioxid. Redox Signal. 15, 233–270.
AgazieYM, HaymanMJ. Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling. Mol Cell Biol, 23:7875–7886. 2003.
5.
AhsanMK, LekliI, RayD, YodoiJ, DasDK. Redox regulation of cell survival by the thioredoxin superfamily: an implication of redox gene therapy in the heart. Antioxid Redox Signal, 11:2741–2758. 2009.
6.
AksenovM, AksenovaM, ButterfieldDA, MarkesberyWR. Oxidative modification of creatine kinase BB in Alzheimer's disease brain. J Neurochem, 74:2520–2527. 2000.
7.
AksenovMY, AksenovaMV, ButterfieldDA, GeddesJW, MarkesberyWR. Protein oxidation in the brain in Alzheimer's disease. Neuroscience, 103:373–383. 2001.
8.
AksenovMY, TuckerHM, NairP, AksenovaMV, ButterfieldDA, EstusS, MarkesberyWR. The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease. Neurochem Res, 24:767–774. 1999.
9.
AkterinS, CowburnRF, Miranda-VizueteA, JimenezA, BogdanovicN, WinbladB, Cedazo-MinguezA. Involvement of glutaredoxin-1 and thioredoxin-1 in beta-amyloid toxicity and Alzheimer's disease. Cell Death Differ, 13:1454–1465. 2006.
10.
AnathyV, AesifSW, GualaAS, HavermansM, ReynaertNL, HoYS, BuddRC, Janssen-HeiningerYM. Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas. J Cell Biol, 184:241–252. 2009.
11.
AnsariMA, RobertsKN, ScheffSW. Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury. Free Radic Biol Med, 45:443–452. 2008.
12.
Aracena-ParksP, GoonasekeraSA, GilmanCP, DirksenRT, HidalgoC, HamiltonSL. Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1. J Biol Chem, 281:40354–40368. 2006.
13.
AsanumaM, MiyazakiI, Diaz-CorralesFJ, OgawaN. Quinone formation as dopaminergic neuron-specific oxidative stress in the pathogenesis of sporadic Parkinson's disease and neurotoxin-induced parkinsonism. Acta Med Okayama, 58:221–233. 2004.
14.
AtamnaH. Amino acids variations in Amyloid-beta peptides, mitochondrial dysfunction, and new therapies for Alzheimer's disease. J Bioenerg Biomembr, 41:457–464. 2009.
15.
BarrettWC, DeGnoreJP, KonigS, FalesHM, KengYF, ZhangZY, YimMB, ChockPB. Regulation of PTP1B via glutathionylation of the active site cysteine 215. Biochemistry, 38:6699–6705. 1999.
16.
BauerPO, NukinaN. The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies. J Neurochem, 110:1737–1765. 2009.
17.
BayirH, AdelsonPD, WisniewskiSR, ShoreP, LaiY, BrownD, Janesko-FeldmanKL, KaganVE, KochanekPM. Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children. Crit Care Med, 37:689–695. 2009.
18.
BayirH, KaganVE, TyurinaYY, TyurinV, RuppelRA, AdelsonPD, GrahamSH, JaneskoK, ClarkRS, KochanekPM. Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatr Res, 51:571–578. 2002.
19.
BeerSM, TaylorER, BrownSE, DahmCC, CostaNJ, RunswickMJ, MurphyMP. Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE. J Biol Chem, 279:47939–47951. 2004.
20.
BiniL, MagiB, MarzocchiB, ArcuriF, TripodiS, CintorinoM, SanchezJC, FrutigerS, HughesG, PalliniV, HochstrasserDF, TosiP. Protein expression profiles in human breast ductal carcinoma and histologically normal tissue. Electrophoresis, 18:2832–2841. 1997.
21.
BirkenmeierG, StegemannC, HoffmannR, GuntherR, HuseK, BirkemeyerC. Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation. PLoS One, 5:e10399.
22.
BishopGM, DringenR, RobinsonSR. Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits glutathione reductase in astrocytes. Free Radic Biol Med, 42:1222–1230. 2007.
23.
BizatN, HermelJM, BoyerF, JacquardC, CreminonC, OuaryS, EscartinC, HantrayeP, KajewskiS, BrouilletE. Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: implications for Huntington's disease. J Neurosci, 23:5020–5030. 2003.
24.
Boyd-KimballD, SultanaR, PoonHF, Mohmmad-AbdulH, LynnBC, KleinJB, ButterfieldDA. Gamma-glutamylcysteine ethyl ester protection of proteins from Abeta(1–42)-mediated oxidative stress in neuronal cell culture: a proteomics approach. J Neurosci Res, 79:707–713. 2005.
25.
BrewerJW, DiehlJA. PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proc Natl Acad Sci U S A, 97:12625–12630. 2000.
26.
BrouilletE, JacquardC, BizatN, BlumD. 3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease. J Neurochem, 95:1521–1540. 2005.
27.
BrowneSE, BowlingAC, MacGarveyU, BaikMJ, BergerSC, MuqitMM, BirdED, BealMF. Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia. Ann Neurol, 41:646–653. 1997.
28.
BrownleeM. Biochemistry and molecular cell biology of diabetic complications. Nature, 414:813–820. 2001.
29.
CalabreseV, SultanaR, ScapagniniG, GuaglianoE, SapienzaM, BellaR, KanskiJ, PennisiG, MancusoC, StellaAM, ButterfieldDA. Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease. Antioxid Redox Signal, 8:1975–1986. 2006.
30.
CasagrandeS, BonettoV, FratelliM, GianazzaE, EberiniI, MassignanT, SalmonaM, ChangG, HolmgrenA, GhezziP. Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems. Proc Natl Acad Sci U S A, 99:9745–9749. 2002.
31.
CastegnaA, AksenovM, ThongboonkerdV, KleinJB, PierceWM, BoozeR, MarkesberyWR, ButterfieldDA. Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71. J Neurochem, 82:1524–1532. 2002.
32.
Castro-CaldasM, Neves CarvalhoA, PeixeiroI, RodriguesE, LechnerMC, GamaMJ. GSTpi expression in MPTP-induced dopaminergic neurodegeneration of C57BL/6 mouse midbrain and striatum. J Mol Neurosci, 38:114–127. 2009.
33.
ChakrabartyS, HuangS. Modulation of chemosensitivity in human colon carcinoma cells by downregulating protein kinase C alpha expression. J Exp Ther Oncol, 1:218–221. 1996.
34.
ChamounR, SukiD, GopinathSP, GoodmanJC, RobertsonC. Role of extracellular glutamate measured by cerebral microdialysis in severe traumatic brain injury. J Neurosurg, 113:564–570. 2010.
35.
ChenCM, WuYR, ChengML, LiuJL, LeeYM, LeePW, SoongBW, ChiuDT. Increased oxidative damage and mitochondrial abnormalities in the peripheral blood of Huntington's disease patients. Biochem Biophys Res Commun, 359:335–340. 2007.
36.
ChenJ, ChenCL, RawaleS, ChenCA, ZweierJL, KaumayaPT, ChenYR. Peptide-based antibodies against glutathione-binding domains suppress superoxide production mediated by mitochondrial complex I. J Biol Chem, 285:3168–3180.
37.
ChengG, IkedaY, IuchiY, FujiiJ. Detection of S-glutathionylated proteins by glutathione S-transferase overlay. Arch Biochem Biophys, 435:42–49. 2005.
38.
ChintaSJ, AndersenJK. Reversible inhibition of mitochondrial complex I activity following chronic dopaminergic glutathione depletion in vitro: implications for Parkinson's disease. Free Radic Biol Med, 41:1442–1448. 2006.
39.
ChintaSJ, KumarJM, ZhangH, FormanHJ, AndersenJK. Up-regulation of gamma-glutamyl transpeptidase activity following glutathione depletion has a compensatory rather than an inhibitory effect on mitochondrial complex I activity: implications for Parkinson's disease. Free Radic Biol Med, 40:1557–1563. 2006.
40.
ChintaSJ, KumarMJ, HsuM, RajagopalanS, KaurD, RaneA, NichollsDG, ChoiJ, AndersenJK. Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. J Neurosci, 27:13997–14006. 2007.
41.
ChintaSJ, RajagopalanS, ButterfieldDA, AndersenJK. In vitro and in vivo neuroprotection by gamma-glutamylcysteine ethyl ester against MPTP: relevance to the role of glutathione in Parkinson's disease. Neurosci Lett, 402:137–141. 2006.
42.
ChiuehCC, AndohT, LaiAR, LaiE, KrishnaG. Neuroprotective strategies in Parkinson's disease: protection against progressive nigral damage induced by free radicals. Neurotox Res, 2:293–310. 2000.
43.
ChoIH, ImJY, KimD, KimKS, LeeJK, HanPL. Protective effects of extracellular glutathione against Zn2+-induced cell death in vitro and in vivo. J Neurosci Res, 74:736–743. 2003.
44.
ChongZZ, MaieseK. The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury. Histol Histopathol, 22:1251–1267. 2007.
45.
ChooYS, MaoZ, JohnsonGV, LesortM. Increased glutathione levels in cortical and striatal mitochondria of the R6/2 Huntington's disease mouse model. Neurosci Lett, 386:63–68. 2005.
46.
ChristofkHR, Vander HeidenMG, HarrisMH, RamanathanA, GersztenRE, WeiR, FlemingMD, SchreiberSL, CantleyLC. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature, 452:230–233. 2008.
47.
ChuF, WardNE, O'BrianCA. PKC isozyme S-cysteinylation by cystine stimulates the pro-apoptotic isozyme PKC delta and inactivates the oncogenic isozyme PKC epsilon. Carcinogenesis, 24:317–325. 2003.
48.
ChuF, WardNE, O'BrianCA. Potent inactivation of representative members of each PKC isozyme subfamily and PKD via S-thiolation by the tumor-promotion/progression antagonist glutathione but not by its precursor cysteine. Carcinogenesis, 22:1221–1229. 2001.
49.
CiuchiE, OdettiP, PrandoR. Relationship between glutathione and sorbitol concentrations in erythrocytes from diabetic patients. Metabolism, 45:611–613. 1996.
50.
ClementMV, StamenkovicI. Superoxide anion is a natural inhibitor of FAS-mediated cell death. EMBO J, 15:216–225. 1996.
51.
ConklinDJ, HaberzettlP, ProughRA, BhatnagarA. Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke. Am J Physiol Heart Circ Physiol, 296:H1586–H1597. 2009.
52.
CortiA, PaolicchiA, FranziniM, DominiciS, CasiniAF, PompellaA. The S-thiolating activity of membrane gamma-glutamyltransferase: formation of cysteinyl-glycine mixed disulfides with cellular proteins and in the cell microenvironment. Antioxid Redox Signal, 7:911–918. 2005.
53.
CrossJV, TempletonDJ. Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain. Biochem J, 381:675–683. 2004.
54.
CruzCM, RinnaA, FormanHJ, VenturaAL, PersechiniPM, OjciusDM. ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem, 282:2871–2879. 2007.
55.
CulottaVC, KlompLW, StrainJ, CasarenoRL, KremsB, GitlinJD. The copper chaperone for superoxide dismutase. J Biol Chem, 272:23469–23472. 1997.
56.
CurtisJM, GrimsrudPA, WrightWS, XuX, FonceaRE, GrahamDW, BrestoffJR, WiczerBM, IlkayevaO, CianfloneK, MuoioDE, ArriagaEA, BernlohrDA. Down regulation of adipose glutathione S-transferase leads to increased protein carbonylation, oxidative stress and mitochondrial dysfunction. Diabetes, 59:1132–1142. 2010.
57.
Dalle-DonneI, GiustariniD, RossiR, ColomboR, MilzaniA. Reversible S-glutathionylation of Cys 374 regulates actin filament formation by inducing structural changes in the actin molecule. Free Radic Biol Med, 34:23–32. 2003.
58.
Dalle-DonneI, RossiR, GiustariniD, ColomboR, MilzaniA. Actin S-glutathionylation: evidence against a thiol-disulphide exchange mechanism. Free Radic Biol Med, 35:1185–1193. 2003.
59.
DanielsonSR, AndersenJK. Oxidative and nitrative protein modifications in Parkinson's disease. Free Radic Biol Med, 44:1787–1794. 2008.
60.
DarmaunD, SmithSD, SweetenS, HartmanBK, WelchS, MaurasN. Poorly controlled type 1 diabetes is associated with altered glutathione homeostasis in adolescents: apparent resistance to N-acetylcysteine supplementation. Pediatr Diabetes, 9:577–582. 2008.
61.
DarmaunD, SmithSD, SweetenS, SagerBK, WelchS, MaurasN. Evidence for accelerated rates of glutathione utilization and glutathione depletion in adolescents with poorly controlled type 1 diabetes. Diabetes, 54:190–196. 2005.
62.
DauerW, PrzedborskiS. Parkinson's disease: mechanisms and models. Neuron, 39:889–909. 2003.
63.
de HemptinneV, RondasD, VandekerckhoveJ, VancompernolleK. Tumour necrosis factor induces phosphorylation primarily of the nitric-oxide-responsive form of glyoxalase I. Biochem J, 407:121–128. 2007.
64.
DeKoskyST, TaffeKM, AbrahamsonEE, DixonCE, KochanekPM, IkonomovicMD. Time course analysis of hippocampal nerve growth factor and antioxidant enzyme activity following lateral controlled cortical impact brain injury in the rat. J Neurotrauma, 21:491–500. 2004.
65.
DemasiM, ShringarpureR, DaviesKJ. Glutathiolation of the proteasome is enhanced by proteolytic inhibitors. Arch Biochem Biophys, 389:254–263. 2001.
66.
Di DomenicoF, CeniniG, SultanaR, PerluigiM, UbertiD, MemoM, ButterfieldDA. Glutathionylation of the pro-apoptotic protein p53 in Alzheimer's disease brain: implications for AD pathogenesis. Neurochem Res, 34:727–733. 2009.
67.
DickersonBC, SperlingRA. Large-scale functional brain network abnormalities in Alzheimer's disease: insights from functional neuroimaging. Behav Neurol, 21:63–75. 2009.
68.
DinotoL, DetureMA, PurichDL. Structural insights into Alzheimer filament assembly pathways based on site-directed mutagenesis and S-glutathionylation of three-repeat neuronal Tau protein. Microsc Res Tech, 67:156–163. 2005.
69.
Djavaheri-MergnyM, AccaouiMJ, RouillardD, WietzerbinJ. Gamma-glutamyl transpeptidase activity mediates NF-kappaB activation through lipid peroxidation in human leukemia U937 cells. Mol Cell Biochem, 232:103–111. 2002.
70.
DominiciS, ValentiniM, MaellaroE, Del BelloB, PaolicchiA, LorenziniE, TongianiR, ComportiM, PompellaA. Redox modulation of cell surface protein thiols in U937 lymphoma cells: the role of gamma-glutamyl transpeptidase-dependent H2O2 production and S-thiolation. Free Radic Biol Med, 27:623–635. 1999.
71.
DringenR, KranichO, LoschmannPA, HamprechtB. Use of dipeptides for the synthesis of glutathione by astroglia-rich primary cultures. J Neurochem, 69:868–874. 1997.
72.
DringenR, PfeifferB, HamprechtB. Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione. J Neurosci, 19:562–569. 1999.
73.
DunstoneMA, DaiW, WhisstockJC, RossjohnJ, PikeRN, FeilSC, Le BonniecBF, ParkerMW, BottomleySP. Cleaved antitrypsin polymers at atomic resolution. Protein Sci, 9:417–420. 2000.
74.
EngelenderS. Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease. Autophagy, 4:372–374. 2008.
75.
EnoiuM, AberkaneH, SalazarJF, LeroyP, GroffenJ, SiestG, WellmanM. Evidence for the pro-oxidant effect of gamma-glutamyltranspeptidase-related enzyme. Free Radic Biol Med, 29:825–833. 2000.
76.
FanP, YamauchiT, NobleLJ, FerrieroDM. Age-dependent differences in glutathione peroxidase activity after traumatic brain injury. J Neurotrauma, 20:437–445. 2003.
77.
FeldmanDE, ChauhanV, KoongAC. The unfolded protein response: a novel component of the hypoxic stress response in tumors. Mol Cancer Res, 3:597–605. 2005.
78.
FiaschiT, CozziG, RaugeiG, FormigliL, RamponiG, ChiarugiP. Redox regulation of beta-actin during integrin-mediated cell adhesion. J Biol Chem, 281:22983–22991. 2006.
FindlayVJ, TownsendDM, MorrisTE, FraserJP, HeL, TewKD. A novel role for human sulfiredoxin in the reversal of glutathionylation. Cancer Res, 66:6800–6806. 2006.
81.
FirdausWJ, WyttenbachA, Diaz-LatoudC, CurrieRW, ArrigoAP. Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant. FEBS J, 273:3076–3093. 2006.
82.
FisherPB, GoldsteinNI, BonnerDP, MechlinskiW, BrysonV, SchaffnerCP. Toxicity of amphotericin B and its methyl ester toward normal and tumor cell lines. Cancer Res, 35:1996–1999. 1975.
83.
FiskumG, StarkovA, PolsterBM, ChinopoulosC. Mitochondrial mechanisms of neural cell death and neuroprotective interventions in Parkinson's disease. Ann N Y Acad Sci, 991:111–119. 2003.
84.
FoxJH, BarberDS, SinghB, ZuckerB, SwindellMK, NorflusF, BuzescuR, ChopraR, FerranteRJ, KazantsevA, HerschSM. Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation. J Neurochem, 91:413–422. 2004.
85.
FrancoR, CidlowskiJA. Apoptosis and glutathione: beyond an antioxidant. Cell Death Differ, 16:1303–1314. 2009.
86.
FratelliM, DemolH, PuypeM, CasagrandeS, EberiniI, SalmonaM, BonettoV, MengozziM, DuffieuxF, MicletE, BachiA, VandekerckhoveJ, GianazzaE, GhezziP. Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes. Proc Natl Acad Sci U S A, 99:3505–3510. 2002.
87.
FukuiH, MoraesCT. Extended polyglutamine repeats trigger a feedback loop involving the mitochondrial complex III, the proteasome and huntingtin aggregates. Hum Mol Genet, 16:783–797. 2007.
88.
FurukawaY, O'HalloranTV. Posttranslational modifications in Cu,Zn-superoxide dismutase and mutations associated with amyotrophic lateral sclerosis. Antioxid Redox Signal, 8:847–867. 2006.
89.
GalloglyMM, SheltonMD, QanungoS, PaiHV, StarkeDW, HoppelCL, LesnefskyEJ, MieyalJJ. Glutaredoxin regulates apoptosis in cardiomyocytes via NFkappaB targets Bcl-2 and Bcl-xL: implications for cardiac aging. Antioxid Redox Signal, 12:1339–1353. 2010.
90.
GalloglyMM, StarkeDW, LeonbergAK, OspinaSM, MieyalJJ. Kinetic and mechanistic characterization and versatile catalytic properties of mammalian glutaredoxin 2: implications for intracellular roles. Biochemistry, 47:11144–11157. 2008.
91.
GanjiSH, QinS, ZhangL, KamannaVS, KashyapML. Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells. Atherosclerosis, 202:68–75. 2009.
92.
GardnerTW, EllerAW, FribergTR. Reduction of severe macular edema in eyes with poor vision after panretinal photocoagulation for proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol, 229:323–328. 1991.
93.
GatchelJR, ZoghbiHY. Diseases of unstable repeat expansion: mechanisms and common principles. Nat Rev Genet, 6:743–755. 2005.
94.
GateL, MajumdarRS, LunkA, TewKD. Increased myeloproliferation in glutathione S-transferase pi-deficient mice is associated with a deregulation of JNK and Janus kinase/STAT pathways. J Biol Chem, 279:8608–8616. 2004.
95.
GeritsN, KostenkoS, ShiryaevA, JohannessenM, MoensU. Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: comradeship and hostility. Cell Signal, 20:1592–1607. 2008.
96.
GhezziP, RominesB, FratelliM, EberiniI, GianazzaE, CasagrandeS, LaragioneT, MengozziM, HerzenbergLA. Protein glutathionylation: coupling and uncoupling of glutathione to protein thiol groups in lymphocytes under oxidative stress and HIV infection. Mol Immunol, 38:773–780. 2002.
97.
GiassonBI, DudaJE, MurrayIV, ChenQ, SouzaJM, HurtigHI, IschiropoulosH, TrojanowskiJQ, LeeVM. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science, 290:985–989. 2000.
GilesGI. The redox regulation of thiol dependent signaling pathways in cancer. Curr Pharm Des, 12:4427–4443. 2006.
100.
GiovannaC, CecchiC, PensalfiniA, BoniniSA, Ferrari-ToninelliG, LiguriG, MemoM, UbertiD. Generation of reactive oxygen species by beta amyloid fibrils and oligomers involves different intra/extracellular pathways. Amino Acids, 38:1101–1106. 2010.
101.
GiustariniD, MilzaniA, AldiniG, CariniM, RossiR, Dalle-DonneI. S-nitrosation versus S-glutathionylation of protein sulfhydryl groups by S-nitrosoglutathione. Antioxid Redox Signal, 7:930–939. 2005.
102.
GivertzMM, ColucciWS. New targets for heart-failure therapy: endothelin, inflammatory cytokines, and oxidative stress. Lancet, 352,Suppl 1:SI34–SI38. 1998.
103.
Gomez-NinoA, AgapitoMT, ObesoA, GonzalezC. Effects of mitochondrial poisons on glutathione redox potential and carotid body chemoreceptor activity. Respir Physiol Neurobiol, 165:104–111. 2009.
104.
GopalakrishnaR, JakenS. Protein kinase C signaling and oxidative stress. Free Radic Biol Med, 28:1349–1361. 2000.
105.
GossJR, TaffeKM, KochanekPM, DeKoskyST. The antioxidant enzymes glutathione peroxidase and catalase increase following traumatic brain injury in the rat. Exp Neurol, 146:291–294. 1997.
106.
GuM, GashMT, MannVM, Javoy-AgidF, CooperJM, SchapiraAH. Mitochondrial defect in Huntington's disease caudate nucleus. Ann Neurol, 39:385–389. 1996.
107.
GumireddyK, SunF, Klein-SzantoAJ, GibbinsJM, GimottyPA, SaundersAJ, SchultzPG, HuangQ. In vivo selection for metastasis promoting genes in the mouse. Proc Natl Acad Sci U S A, 104:6696–6701. 2007.
108.
HaendelerJ. Thioredoxin-1 and posttranslational modifications. Antioxid Redox Signal, 8:1723–1728. 2006.
109.
Hamnell-PammentY, LindC, PalmbergC, BergmanT, CotgreaveIA. Determination of site-specificity of S-glutathionylated cellular proteins. Biochem Biophys Res Commun, 332:362–369. 2005.
110.
HamptonMB, OrreniusS. Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis. FEBS Lett, 414:552–556. 1997.
111.
HanD, HanawaN, SaberiB, KaplowitzN. Mechanisms of liver injury. III. Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol, 291:G1–G7. 2006.
112.
HaniganMH, FriersonHF.Jr. Immunohistochemical detection of gamma-glutamyl transpeptidase in normal human tissue. J Histochem Cytochem, 44:1101–1108. 1996.
113.
HansenRE, RothD, WintherJR. Quantifying the global cellular thiol-disulfide status. Proc Natl Acad Sci U S A, 106:422–427. 2009.
114.
HarveyBH, JoubertC, du PreezJL, BerkM. Effect of chronic N-acetyl cysteine administration on oxidative status in the presence and absence of induced oxidative stress in rat striatum. Neurochem Res, 33:508–517. 2008.
115.
HatahetF, RuddockLW. Protein disulfide isomerase: a critical evaluation of its function in disulfide bond formation. Antioxid Redox Signal, 11:2807–2850. 2009.
116.
HebertSS, HorreK, NicolaiL, BergmansB, PapadopoulouAS, DelacourteA, De StrooperB. MicroRNA regulation of Alzheimer's amyloid precursor protein expression. Neurobiol Dis, 33:422–428. 2009.
117.
HebertSS, HorreK, NicolaiL, PapadopoulouAS, MandemakersW, SilahtarogluAN, KauppinenS, DelacourteA, De StrooperB. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A, 105:6415–6420. 2008.
118.
HetzC, BernasconiP, FisherJ, LeeAH, BassikMC, AntonssonB, BrandtGS, IwakoshiNN, SchinzelA, GlimcherLH, KorsmeyerSJ. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science, 312:572–576. 2006.
119.
HicdonmezT, KanterM, TiryakiM, ParsakT, CobanogluS. Neuroprotective effects of N-acetylcysteine on experimental closed head trauma in rats. Neurochem Res, 31:473–481. 2006.
120.
HidalgoC, SanchezG, BarrientosG, Aracena-ParksP. A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S-glutathionylation. J Biol Chem, 281:26473–26482. 2006.
121.
HinzmanJ, ThomasT, BurmeisterJJ, QuinteroJ, HuettlP, PomerleauF, GerhardtG, LifshitzJ. Diffuse brain injury elevates tonic glutamate levels and potassium-evoked glutamate release in discrete brain regions at two days post-injury: an enzyme-based microelectrode array study. J Neurotrauma, 27:889–899. 2010.
122.
HiratsukaS, WatanabeA, AburataniH, MaruY. Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol, 8:1369–1375. 2006.
123.
HiroseM, HayanoT, ShiraiH, NakamuraH, KikuchiM. Isolation of anti-glutathione antibodies from a phage display library. Protein Eng, 11:243–248. 1998.
124.
HoffmannP, WoonJ, RowleyKG, KarschimkusC, NelsonCL, DragicevicG, O'NealD, WilsonA, CroftKD, MoriTA, KempBE, BestJD, JenkinsAJ. Glutathionyl haemoglobin is not increased in diabetes nor related to glycaemia, complications, dyslipidaemia, inflammation or other measures of oxidative stress. Diabetes Res Clin Pract, 80:e1–e3. 2008.
125.
HopkinsFG. On an Autoxidisable Constituent of the Cell. Biochem J, 15:286–305. 1921.
126.
HuangKP, HuangFL. Glutathionylation of proteins by glutathione disulfide S-oxide. Biochem Pharmacol, 64:1049–1056. 2002.
127.
HuangZ, PintoJT, DengH, RichieJP.Jr. Inhibition of caspase-3 activity and activation by protein glutathionylation. Biochem Pharmacol, 75:2234–2244. 2008.
HumphriesKM, JulianoC, TaylorSS. Regulation of cAMP-dependent protein kinase activity by glutathionylation. J Biol Chem, 277:43505–43511. 2002.
130.
HutchensS, ManevichY, HeL, TewKD, TownsendDM. Cellular resistance to a nitric oxide releasing glutathione S-transferase P-activated prodrug, PABA/NO. Invest New Drugs.
131.
Iijima-AndoK, HearnSA, ShentonC, GattA, ZhaoL, IijimaK. Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease. PLoS One, 4:e8310. 2009.
132.
IraniK, XiaY, ZweierJL, SollottSJ, DerCJ, FearonER, SundaresanM, FinkelT, Goldschmidt-ClermontPJ. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science, 275:1649–1652. 1997.
133.
JaffreySR, SnyderSH. The biotin switch method for the detection of S-nitrosylated proteins. Sci STKE, 2001:pl1. 2001.
134.
JhaN, JurmaO, LalliG, LiuY, PettusEH, GreenamyreJT, LiuRM, FormanHJ, AndersenJK. Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease. J Biol Chem, 275:26096–26101. 2000.
135.
JinW, WangH, YanW, ZhuL, HuZ, DingY, TangK. Role of Nrf2 in protection against traumatic brain injury in mice. J Neurotrauma, 26:131–139. 2009.
136.
JinushiM, VannemanM, MunshiNC, TaiYT, PrabhalaRH, RitzJ, NeubergD, AndersonKC, CarrascoDR, DranoffG. MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma. Proc Natl Acad Sci U S A, 105:1285–1290. 2008.
137.
JuTC, ChenSD, LiuCC, YangDI. Protective effects of S-nitrosoglutathione against amyloid beta-peptide neurotoxicity. Free Radic Biol Med, 38:938–949. 2005.
138.
JuTC, YangYT, YangDI. Protective effects of S-nitrosoglutathione against neurotoxicity of 3-nitropropionic acid in rat. Neurosci Lett, 362:226–231. 2004.
139.
KangPT, YunJ, KaumayaPP, ChenYR. Design and use of peptide-based antibodies decreasing superoxide production by mitochondrial complex I and complex II. Biopolymers, 2010[Epub ahead of print].
140.
KarinM, LinA. NF-kappaB at the crossroads of life and death. Nat Immunol, 3:221–227. 2002.
141.
KearneyM, OrrellRW, FaheyM, PandolfoM. Antioxidants and other pharmacological treatments for Friedreich ataxia. Cochrane Database Syst Rev, 4:CD007791. 2009.
142.
KhanM, ImYB, ShunmugavelA, GilgAG, DhindsaRK, SinghAK, SinghI. Administration of S-nitrosoglutathione after traumatic brain injury protects the neurovascular unit and reduces secondary injury in a rat model of controlled cortical impact. J Neuroinflammation, 6:32. 2009.
143.
KimYJ, LeeWS, IpC, ChaeHZ, ParkEM, ParkYM. Prx1 suppresses radiation-induced c-Jun NH2-terminal kinase signaling in lung cancer cells through interaction with the glutathione S-transferase Pi/c-Jun NH2-terminal kinase complex. Cancer Res, 66:7136–7142. 2006.
144.
KlattP, MolinaEP, LamasS. Nitric oxide inhibits c-Jun DNA binding by specifically targeted S-glutathionylation. J Biol Chem, 274:15857–15864. 1999.
145.
KlepacN, ReljaM, KlepacR, HecimovicS, BabicT, TrkuljaV. Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects: a cross-sectional study. J Neurol, 254:1676–1683. 2007.
146.
KrautwaldS, BuscherD, KummerV, BuderS, BaccariniM. Involvement of the protein tyrosine phosphatase SHP-1 in Ras-mediated activation of the mitogen-activated protein kinase pathway. Mol Cell Biol, 16:5955–5963. 1996.
147.
KumarP, KumarA. Neuroprotective effect of cyclosporine and FK506 against 3-nitropropionic acid induced cognitive dysfunction and glutathione redox in rat: possible role of nitric oxide. Neurosci Res, 63:302–314. 2009.
148.
LaiY, HickeyRW, ChenY, BayirH, SullivanML, ChuCT, KochanekPM, DixonCE, JenkinsLW, GrahamSH, WatkinsSC, ClarkRS. Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester. J Cereb Blood Flow Metab, 28:540–550. 2008.
149.
LandinoLM, BrownCM, EdsonCA, GilbertLJ, Grega-LarsonN, WirthAJ, LaneKC. Fluorescein-labeled glutathione to study protein S-glutathionylation. Anal Biochem, 402:102–104. 2010.
150.
LawRH, ZhangQ, McGowanS, BuckleAM, SilvermanGA, WongW, RosadoCJ, LangendorfCG, PikeRN, BirdPI, WhisstockJC. An overview of the serpin superfamily. Genome Biol, 7:216. 2006.
151.
LeeE, JeongJ, KimSE, SongEJ, KangSW, LeeKJ. Multiple functions of Nm23-H1 are regulated by oxido-reduction system. PLoS One, 4:e7949. 2009.
152.
LehmannC, BetteS, EngeleJ. High extracellular glutamate modulates expression of glutamate transporters and glutamine synthetase in cultured astrocytes. Brain Res, 1297:1–8. 2009.
153.
LevesqueJP, LiuF, SimmonsPJ, BetsuyakuT, SeniorRM, PhamC, LinkDC. Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood, 104:65–72. 2004.
154.
LiJY, PopovicN, BrundinP. The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies. NeuroRx, 2:447–464. 2005.
155.
LiaoBC, HsiehCW, LinYC, WungBS. The glutaredoxin/glutathione system modulates NF-{kappa}B activity by glutathionylation of p65 in cinnamaldehyde-treated endothelial cells. Toxicol Sci, 116:151–163. 2010.
LindC, GerdesR, HamnellY, Schuppe-KoistinenI, von LowenhielmHB, HolmgrenA, CotgreaveIA. Identification of S-glutathionylated cellular proteins during oxidative stress and constitutive metabolism by affinity purification and proteomic analysis. Arch Biochem Biophys, 406:229–240. 2002.
158.
LiotG, BossyB, LubitzS, KushnarevaY, SejbukN, Bossy-WetzelE. Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway. Cell Death Differ, 16:899–909. 2009.
LomasDA, EvansDL, FinchJT, CarrellRW. The mechanism of Z alpha 1-antitrypsin accumulation in the liver. Nature, 357:605–607. 1992.
161.
LynnBC, WangJ, MarkesberyWR, LovellMA. Quantitative changes in the mitochondrial proteome from subjects with mild cognitive impairment, early stage, and late stage Alzheimer's disease. J Alzheimers Dis, 19:325–339. 2010.
162.
MaasAI, StocchettiN, BullockR. Moderate and severe traumatic brain injury in adults. Lancet Neurol, 7:728–741. 2008.
163.
MagnaniM, NovelliG, PalloniR. Human plasma glutathione oxidation in normal and pathological conditions. Clin Physiol Biochem, 2:287–290. 1984.
164.
MalikG, NagyN, HoYS, MaulikN, DasDK. Role of glutaredoxin-1 in cardioprotection: an insight with Glrx1 transgenic and knockout animals. J Mol Cell Cardiol, 44:261–269. 2008.
165.
ManevichY, FeinsteinSI, FisherAB. Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST. Proc Natl Acad Sci U S A, 101:3780–3785. 2004.
166.
ManevichY, TownsendDM, HutchensS, TewKD. Diazeniumdiolate mediated nitrosative stress alters nitric oxide homeostasis through intracellular calcium and S-glutathionylation of nitric oxide synthetase. PLoS One, 5:e14151. 2010.
MartinHL, TeismannP. Glutathione—a review on its role and significance in Parkinson's disease. FASEB J, 23:3263–3272. 2009.
169.
MasonJK. Recording HIV status on police computers. BMJ, 304:995–996. 1992.
170.
MatozakiT, MurataY, SaitoY, OkazawaH, OhnishiH. Protein tyrosine phosphatase SHP-2: a proto-oncogene product that promotes Ras activation. Cancer Sci, 100:1786–1793. 2009.
171.
MatsudaM, MasutaniH, NakamuraH, MiyajimaS, YamauchiA, YoneharaS, UchidaA, IrimajiriK, HoriuchiA, YodoiJ. Protective activity of adult T cell leukemia-derived factor (ADF) against tumor necrosis factor-dependent cytotoxicity on U937 cells. J Immunol, 147:3837–3841. 1991.
172.
McClungJP, RonekerCA, MuW, LiskDJ, LanglaisP, LiuF, LeiXG. Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. Proc Natl Acad Sci U S A, 101:8852–8857. 2004.
173.
McIlwainCC, TownsendDM, TewKD. Glutathione S-transferase polymorphisms: cancer incidence and therapy. Oncogene, 25:1639–1648. 2006.
174.
McKiernanE, O'BrienK, GrebenchtchikovN, Geurts-MoespotA, SieuwertsAM, MartensJW, MagdolenV, EvoyD, McDermottE, CrownJ, SweepFC, DuffyMJ. Protein kinase Cdelta expression in breast cancer as measured by real-time PCR, western blotting and ELISA. Br J Cancer, 99:1644–1650. 2008.
175.
McLellanLI, LewisAD, HallDJ, AnsellJD, WolfCR. Uptake and distribution of N-acetylcysteine in mice: tissue-specific effects on glutathione concentrations. Carcinogenesis, 16:2099–2106. 1995.
176.
MeekDW, HuppTR. The regulation of MDM2 by multisite phosphorylation-opportunities for molecular-based intervention to target tumours?Semin Cancer Biol, 20:19–28. 2010.
177.
MieyalJJ, GalloglyMM, QanungoS, SabensEA, SheltonMD. Molecular mechanisms and clinical implications of reversible protein S-glutathionylation. Antioxid Redox Signal, 10:1941–1988. 2008.
178.
MieyalJJ, StarkeDW, GravinaSA, DotheyC, ChungJS. Thioltransferase in human red blood cells: purification and properties. Biochemistry, 30:6088–6097. 1991.
179.
MohrS, HallakH, de BoitteA, LapetinaEG, BruneB. Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem, 274:9427–9430. 1999.
180.
MohrS, ZechB, LapetinaEG, BruneB. Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide. Biochem Biophys Res Commun, 238:387–391. 1997.
MonzonFA, OginoS, HammondME, HallingKC, BloomKJ, NikiforovaMN. The role of KRAS mutation testing in the management of patients with metastatic colorectal cancer. Arch Pathol Lab Med, 133:1600–1606. 2009.
183.
MunozAM, ReyP, Soto-OteroR, GuerraMJ, Labandeira-GarciaJL. Systemic administration of N-acetylcysteine protects dopaminergic neurons against 6-hydroxydopamine-induced degeneration. J Neurosci Res, 76:551–562. 2004.
184.
MurakamiK, KondoT, OhtsukaY, FujiwaraY, ShimadaM, KawakamiY. Impairment of glutathione metabolism in erythrocytes from patients with diabetes mellitus. Metabolism, 38:753–758. 1989.
185.
MurataH, IharaY, NakamuraH, YodoiJ, SumikawaK, KondoT. Glutaredoxin exerts an antiapoptotic effect by regulating the redox state of Akt. J Biol Chem, 278:50226–50233. 2003.
186.
NaitoC, NiwaT. Analysis of glutathionyl hemoglobin levels in diabetic patients by electrospray ionization liquid chromatography-mass spectrometry: effect of vitamin E administration. J Chromatogr B Biomed Sci Appl, 746:91–94. 2000.
187.
NaoiM, MaruyamaW, YiH, InabaK, AkaoY, Shamoto-NagaiM. Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival. J Neural Transm, 116:1371–1381. 2009.
NevesG, CookeSF, BlissTV. Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nat Rev Neurosci, 9:65–75. 2008.
190.
NigamR, AndersonDJ, LeeSF, BennettBM. Isoform-specific biotransformation of glyceryl trinitrate by rat aortic glutathione S-transferases. J Pharmacol Exp Ther, 279:1527–1534. 1996.
191.
NisticoG, CirioloMR, FiskinK, IannoneM, De MartinoA, RotilioG. NGF restores decrease in catalase and increases glutathione peroxidase activity in the brain of aged rats. Neurosci Lett, 130:117–119. 1991.
192.
NitureSK, VeluCS, BaileyNI, SrivenugopalKS. S-thiolation mimicry: quantitative and kinetic analysis of redox status of protein cysteines by glutathione-affinity chromatography. Arch Biochem Biophys, 444:174–184. 2005.
193.
NiwaT, NaitoC, MawjoodAH, ImaiK. Increased glutathionyl hemoglobin in diabetes mellitus and hyperlipidemia demonstrated by liquid chromatography/electrospray ionization-mass spectrometry. Clin Chem, 46:82–88. 2000.
PanS, BerkBC. Glutathiolation regulates tumor necrosis factor-alpha-induced caspase-3 cleavage and apoptosis: key role for glutaredoxin in the death pathway. Circ Res, 100:213–219. 2007.
202.
PaolicchiA, DominiciS, PieriL, MaellaroE, PompellaA. Glutathione catabolism as a signaling mechanism. Biochem Pharmacol, 64:1027–1035. 2002.
203.
ParkJW, MieyalJJ, RheeSG, ChockPB. Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin. J Biol Chem, 284:23364–23374. 2009.
204.
PastoreA, TozziG, GaetaLM, BertiniE, SerafiniV, Di CesareS, BonettoV, CasoniF, CarrozzoR, FedericiG, PiemonteF. Actin glutathionylation increases in fibroblasts of patients with Friedreich's ataxia: a potential role in the pathogenesis of the disease. J Biol Chem, 278:42588–42595. 2003.
205.
PatelN, HoangD, MillerN, AnsaloniS, HuangQ, RogersJT, LeeJC, SaundersAJ. MicroRNAs can regulate human APP levels. Mol Neurodegener, 3:10. 2008.
206.
PavlovPF, PetersenCH, GlaserE, AnkarcronaM. Mitochondrial accumulation of APP and Abeta: significance for Alzheimer disease pathogenesis. J Cell Mol Med, 13:4137–4145. 2009.
207.
Perez-SeverianoF, RiosC, SegoviaJ. Striatal oxidative damage parallels the expression of a neurological phenotype in mice transgenic for the mutation of Huntington's disease. Brain Res, 862:234–237. 2000.
208.
Perez-SeverianoF, SantamariaA, Pedraza-ChaverriJ, Medina-CamposON, RiosC, SegoviaJ. Increased formation of reactive oxygen species, but no changes in glutathione peroxidase activity, in striata of mice transgenic for the Huntington's disease mutation. Neurochem Res, 29:729–733. 2004.
209.
PerrinRJ, FaganAM, HoltzmanDM. Multimodal techniques for diagnosis and prognosis of Alzheimer's disease. Nature, 461:916–922. 2009.
210.
PeskinAV, WinterbournCC. Taurine chloramine is more selective than hypochlorous acid at targeting critical cysteines and inactivating creatine kinase and glyceraldehyde-3-phosphate dehydrogenase. Free Radic Biol Med, 40:45–53. 2006.
211.
PhamFH, SugdenPH, ClerkA. Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes. Circ Res, 86:1252–1258. 2000.
212.
Pineda-MolinaE, KlattP, VazquezJ, MarinaA, Garcia de LacobaM, Perez-SalaD, LamasS. Glutathionylation of the p50 subunit of NF-kappaB: a mechanism for redox-induced inhibition of DNA binding. Biochemistry, 40:14134–14142. 2001.
213.
PinhelMA, NakazoneMA, CacaoJC, PiteriRC, DantasRT, GodoyMF, GodoyMR, TognolaWA, Conforti-FroesND, SouzaD. Glutathione S-transferase variants increase susceptibility for late-onset Alzheimer's disease: association study and relationship with apolipoprotein E epsilon4 allele. Clin Chem Lab Med, 46:439–445. 2008.
214.
PottsMB, RolaR, ClausCP, FerrieroDM, FikeJR, Noble-HaeussleinLJ. Glutathione peroxidase overexpression does not rescue impaired neurogenesis in the injured immature brain. J Neurosci Res, 87:1848–1857. 2009.
215.
PuccioH, SimonD, CosseeM, Criqui-FilipeP, TizianoF, MelkiJ, HindelangC, MatyasR, RustinP, KoenigM. Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits. Nat Genet, 27:181–186. 2001.
216.
Puka-SundvallM, ErikssonP, NilssonM, SandbergM, LehmannA. Neurotoxicity of cysteine: interaction with glutamate. Brain Res, 705:65–70. 1995.
217.
QanungoS, StarkeDW, PaiHV, MieyalJJ, NieminenAL. Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkappaB. J Biol Chem, 282:18427–18436. 2007.
218.
QanungoS, WangM, NieminenAL. N-Acetyl-L-cysteine enhances apoptosis through inhibition of nuclear factor-kappaB in hypoxic murine embryonic fibroblasts. J Biol Chem, 279:50455–50464. 2004.
RalatLA, ManevichY, FisherAB, ColmanRF. Direct evidence for the formation of a complex between 1-cysteine peroxiredoxin and glutathione S-transferase pi with activity changes in both enzymes. Biochemistry, 45:360–372. 2006.
221.
RanganathanS, WalshES, GodwinAK, TewKD. Cloning and characterization of human colon glyoxalase-I. J Biol Chem, 268:5661–5667. 1993.
222.
RaoRK, ClaytonLW. Regulation of protein phosphatase 2A by hydrogen peroxide and glutathionylation. Biochem Biophys Res Commun, 293:610–616. 2002.
223.
RauhalaP, LinAM, ChiuehCC. Neuroprotection by S-nitrosoglutathione of brain dopamine neurons from oxidative stress. FASEB J, 12:165–173. 1998.
224.
RaviK, BrennanLA, LevicS, RossPA, BlackSM. S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity. Proc Natl Acad Sci U S A, 101:2619–2624. 2004.
225.
ReddyPH. Role of mitochondria in neurodegenerative diseases: mitochondria as a therapeutic target in Alzheimer's disease. CNS Spectr, 14:8–13; discussion 16–182009.
226.
ReedTT, OwenJ, PierceWM, SebastianA, SullivanPG, ButterfieldDA. Proteomic identification of nitrated brain proteins in traumatic brain-injured rats treated postinjury with gamma-glutamylcysteine ethyl ester: insights into the role of elevation of glutathione as a potential therapeutic strategy for traumatic brain injury. J Neurosci Res, 87:408–417. 2009.
227.
RegazzoniL, PanusaA, YeumKJ, CariniM, AldiniG. Hemoglobin glutathionylation can occur through cysteine sulfenic acid intermediate: electrospray ionization LTQ-Orbitrap hybrid mass spectrometry studies. J Chromatogr B Analyt Technol Biomed Life Sci, 877:3456–3461. 2009.
228.
ReynaertNL, CklessK, GualaAS, WoutersEF, van der VlietA, Janssen-HeiningerYM. In situ detection of S-glutathionylated proteins following glutaredoxin-1 catalyzed cysteine derivatization. Biochim Biophys Acta, 1760:380–387. 2006.
229.
ReynaertNL, van der VlietA, GualaAS, McGovernT, HristovaM, PantanoC, HeintzNH, HeimJ, HoYS, MatthewsDE, WoutersEF, Janssen-HeiningerYM. Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta. Proc Natl Acad Sci U S A, 103:13086–13091. 2006.
230.
RinnaA, TorresM, FormanHJ. Stimulation of the alveolar macrophage respiratory burst by ADP causes selective glutathionylation of protein tyrosine phosphatase 1B. Free Radic Biol Med, 41:86–91. 2006.
231.
RokutanK, ThomasJA, JohnstonRB.Jr. Phagocytosis and stimulation of the respiratory burst by phorbol diester initiate S-thiolation of specific proteins in macrophages. J Immunol, 147:260–264. 1991.
232.
RosengardAM, KrutzschHC, ShearnA, BiggsJR, BarkerE, MarguliesIM, KingCR, LiottaLA, SteegPS. Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development. Nature, 342:177–180. 1989.
233.
RossiR, GiustariniD, MilzaniA, Dalle-DonneI. Membrane skeletal protein S-glutathionylation and hemolysis in human red blood cells. Blood Cells Mol Dis, 37:180–187. 2006.
234.
RubinszteinDC. The roles of intracellular protein-degradation pathways in neurodegeneration. Nature, 443:780–786. 2006.
SabensEA, DistlerAM, MieyalJJ. Levodopa deactivates enzymes that regulate thiol-disulfide homeostasis and promotes neuronal cell death: implications for therapy of Parkinson's disease. Biochemistry, 49:2715–2724. 2010.
237.
SaeedU, RayA, ValliRK, KumarAM, RavindranathV. DJ-1 loss by glutaredoxin but not glutathione depletion triggers Daxx translocation and cell death. Antioxid Redox Signal, 13:127–144. 2010.
238.
SaitohM, NishitohH, FujiiM, TakedaK, TobiumeK, SawadaY, KawabataM, MiyazonoK, IchijoH. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J, 17:2596–2606. 1998.
239.
SalamaI, MalonePS, MihaimeedF, JonesJL. A review of the S100 proteins in cancer. Eur J Surg Oncol, 34:357–364. 2008.
240.
SampathkumarR, BalasubramanyamM, SudarslalS, RemaM, MohanV, BalaramP. Increased glutathionylated hemoglobin (HbSSG) in type 2 diabetes subjects with microangiopathy. Clin Biochem, 38:892–899. 2005.
241.
SandlerAB. Molecular targeted agents in non-small-cell lung cancer. Clin Lung Cancer 5 Suppl, 1:S22–S28. 2003.
242.
SavittJM, DawsonVL, DawsonTM. Diagnosis and treatment of Parkinson disease: molecules to medicine. J Clin Invest, 116:1744–1754. 2006.
243.
SchrauwenP, HesselinkMK. Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. Diabetes, 53:1412–1417. 2004.
244.
Schuppe-KoistinenI, GerdesR, MoldeusP, CotgreaveIA. Studies on the reversibility of protein S-thiolation in human endothelial cells. Arch Biochem Biophys, 315:226–234. 1994.
245.
SeoYH, CarrollKS. Profiling protein thiol oxidation in tumor cells using sulfenic acid-specific antibodies. Proc Natl Acad Sci U S A, 106:16163–16168. 2009.
246.
SevierCS, QuH, HeldmanN, GrossE, FassD, KaiserCA. Modulation of cellular disulfide-bond formation and the ER redox environment by feedback regulation of Ero1. Cell, 129:333–344. 2007.
247.
SharmaR, BrownD, AwasthiS, YangY, SharmaA, PatrickB, SainiMK, SinghSP, ZimniakP, SinghSV, AwasthiYC. Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells. Eur J Biochem, 271:1690–1701. 2004.
SheltonMD, KernTS, MieyalJJ. Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Muller cells: model of diabetic retinopathy. J Biol Chem, 282:12467–12474. 2007.
250.
SheltonMD, MieyalJJ. Regulation by reversible S-glutathionylation: molecular targets implicated in inflammatory diseases. Mol Cells, 25:332–346. 2008.
251.
ShiM, BradnerJ, BammlerTK, EatonDL, ZhangJ, YeZ, WilsonAM, MontineTJ, PanC. Identification of glutathione S-transferase pi as a protein involved in Parkinson disease progression. Am J Pathol, 175:54–65. 2009.
252.
ShinBK, WangH, YimAM, Le NaourF, BrichoryF, JangJH, ZhaoR, PuravsE, TraJ, MichaelCW, MisekDE, HanashSM. Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. J Biol Chem, 278:7607–7616. 2003.
253.
ShiomiT, TsutsuiH, MatsusakaH, MurakamiK, HayashidaniS, IkeuchiM, WenJ, KubotaT, UtsumiH, TakeshitaA. Overexpression of glutathione peroxidase prevents left ventricular remodeling and failure after myocardial infarction in mice. Circulation, 109:544–549. 2004.
254.
SianJ, DexterDT, LeesAJ, DanielS, AgidY, Javoy-AgidF, JennerP, MarsdenCD. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann Neurol, 36:348–355. 1994.
255.
SiscovickDS, SotoodehniaN, ReaTD, RaghunathanTE, JouvenX, LemaitreRN. Type 2 diabetes mellitus and the risk of sudden cardiac arrest in the community. Rev Endocr Metab Disord, 11:53–59. 2010.
256.
SlemmerJE, ShackaJJ, SweeneyMI, WeberJT. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem, 15:404–414. 2008.
257.
SmeyneM, BoydJ, Raviie ShepherdK, JiaoY, PondBB, HatlerM, WolfR, HendersonC, SmeyneRJ. GSTpi expression mediates dopaminergic neuron sensitivity in experimental parkinsonism. Proc Natl Acad Sci U S A, 104:1977–1982. 2007.
258.
SmithSP, ShawGS. A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form. Structure, 6:211–222. 1998.
259.
SpallettaG, BernardiniS, BellincampiL, FedericiG, TrequattriniA, CiappiF, BriaP, CaltagironeC, BossuP. Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer disease. Am J Geriatr Psychiatry, 15:879–887. 2007.
SpencerJP, JennerA, ButlerJ, AruomaOI, DexterDT, JennerP, HalliwellB. Evaluation of the pro-oxidant and antioxidant actions of L-DOPA and dopamine in vitro: implications for Parkinson's disease. Free Radic Res, 24:95–105. 1996.
262.
StarkAA, ZeigerE, PaganoDA. Glutathione metabolism by gamma-glutamyltranspeptidase leads to lipid peroxidation: characterization of the system and relevance to hepatocarcinogenesis. Carcinogenesis, 14:183–189. 1993.
263.
SullivanDM, WehrNB, FergussonMM, LevineRL, FinkelT. Identification of oxidant-sensitive proteins: TNF-alpha induces protein glutathiolation. Biochemistry, 39:11121–11128. 2000.
264.
SumbayevVV. S-nitrosylation of thioredoxin mediates activation of apoptosis signal-regulating kinase 1. Arch Biochem Biophys, 415:133–136. 2003.
265.
TagliabueM, PinachS, Di BisceglieC, BrocatoL, CassaderM, BertagnaA, ManieriC, PescarmonaGP. Glutathione levels in patients with erectile dysfunction, with or without diabetes mellitus. Int J Androl, 28:156–162. 2005.
266.
TaoL, EnglishAM. Protein S-glutathiolation triggered by decomposed S-nitrosoglutathione. Biochemistry, 43:4028–4038. 2004.
267.
TavazziB, VagnozziR, SignorettiS, AmoriniAM, BelliA, CimattiM, DelfiniR, Di PietroV, FinocchiaroA, LazzarinoG. Temporal window of metabolic brain vulnerability to concussions: oxidative and nitrosative stresses—part II. Neurosurgery, 61:390–395; discussion 395–3962007.
268.
TewKD. Glutathione-associated enzymes in anticancer drug resistance. Cancer Res, 54:4313–4320. 1994.
269.
ThomasB. Parkinson's disease: from molecular pathways in disease to therapeutic approaches. Antioxid Redox Signal, 11:2077–2082. 2009.
270.
TianG, XiangS, NoivaR, LennarzWJ, SchindelinH. The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites. Cell, 124:61–73. 2006.
271.
TownsendDM. S-glutathionylation: indicator of cell stress and regulator of the unfolded protein response. Mol Interv, 7:313–324. 2007.
272.
TownsendDM, FindlayVJ, FazilevF, OgleM, FraserJ, SaavedraJE, JiX, KeeferLK, TewKD. A glutathione S-transferase pi-activated prodrug causes kinase activation concurrent with S-glutathionylation of proteins. Mol Pharmacol, 69:501–508. 2006.
273.
TownsendDM, ManevichY, HeL, HutchensS, PazolesCJ, TewKD. Novel role for glutathione S-transferase pi. Regulator of protein S-glutathionylation following oxidative and nitrosative stress. J Biol Chem, 284:436–445. 2009.
274.
TownsendDM, ManevichY, HeL, XiongY, BowersRRJr., HutchensS, TewKD. Nitrosative stress-induced S-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response. Cancer Res, 69:7626–7634. 2009.
275.
Trujillo-MartinMM, Serrano-AguilarP, Monton-AlvarezF, Carrillo-FumeroR. Effectiveness and safety of treatments for degenerative ataxias: a systematic review. Mov Disord, 24:1111–1124. 2009.
276.
TsuchidaS, MakiT, SatoK. Purification and characterization of glutathione transferases with an activity toward nitroglycerin from human aorta and heart. Multiplicity of the human class Mu forms. J Biol Chem, 265:7150–7157. 1990.
277.
Tsuru-AoyagiK, PottsMB, TrivediA, PfankuchT, RaberJ, WendlandM, ClausCP, KohSE, FerrieroD, Noble-HaeussleinLJ. Glutathione peroxidase activity modulates recovery in the injured immature brain. Ann Neurol, 65:540–549. 2009.
278.
TunezI, Drucker-ColinR, JimenaI, MedinaFJ, Munoz MdelC, PenaJ, MontillaP. Transcranial magnetic stimulation attenuates cell loss and oxidative damage in the striatum induced in the 3-nitropropionic model of Huntington's disease. J Neurochem, 97:619–630. 2006.
279.
TyagiSC. Reversible inhibition of neutrophil elastase by thiol-modified alpha-1 protease inhibitor. J Biol Chem, 266:5279–5285. 1991.
280.
UeharaT, NakamuraT, YaoD, ShiZQ, GuZ, MaY, MasliahE, NomuraY, LiptonSA. S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature, 441:513–517. 2006.
281.
van PelM, van OsR, VeldersGA, HagoortH, HeegaardPM, LindleyIJ, WillemzeR, FibbeWE. Serpina1 is a potent inhibitor of IL-8-induced hematopoietic stem cell mobilization. Proc Natl Acad Sci U S A, 103:1469–1474. 2006.
282.
VassarR, KovacsDM, YanR, WongPC. The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. J Neurosci, 29:12787–12794. 2009.
283.
VeluCS, NitureSK, DoneanuCE, PattabiramanN, SrivenugopalKS. Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress. Biochemistry, 46:7765–7780. 2007.
284.
VilarR, CoelhoH, RodriguesE, GamaMJ, RiveraI, TaioliE, LechnerMC. Association of A313 G polymorphism (GSTP1*B) in the glutathione-S-transferase P1 gene with sporadic Parkinson's disease. Eur J Neurol, 14:156–161. 2007.
285.
ViswanathV, WuY, BoonplueangR, ChenS, StevensonFF, YantiriF, YangL, BealMF, AndersenJK. Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease. J Neurosci, 21:9519–9528. 2001.
286.
VousdenKH, LaneDP. p53 in health and disease. Nat Rev Mol Cell Biol, 8:275–283. 2007.
287.
WadeLA, BradyHM. Cysteine and cystine transport at the blood-brain barrier. J Neurochem, 37:730–734. 1981.
288.
WangH, LimPJ, KarbowskiM, MonteiroMJ. Effects of overexpression of huntingtin proteins on mitochondrial integrity. Hum Mol Genet, 18:737–752. 2009.
WangJ, GreenPS, SimpkinsJW. Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3-nitroproprionic acid in SK-N-SH human neuroblastoma cells. J Neurochem, 77:804–811. 2001.
291.
WangJ, TekleE, OubrahimH, MieyalJJ, StadtmanER, ChockPB. Stable and controllable RNA interference: investigating the physiological function of glutathionylated actin. Proc Natl Acad Sci U S A, 100:5103–5106. 2003.
292.
WangT, ArifogluP, RonaiZ, TewKD. Glutathione S-transferase P1–1 (GSTP1–1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus. J Biol Chem, 276:20999–21003. 2001.
293.
WangWX, RajeevBW, StrombergAJ, RenN, TangG, HuangQ, RigoutsosI, NelsonPT. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci, 28:1213–1223. 2008.
294.
WangXZ, RonD. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase. Science, 272:1347–1349. 1996.
295.
WardNE, StewartJR, IoannidesCG, O'BrianCA. Oxidant-induced S-glutathiolation inactivates protein kinase C-alpha (PKC-alpha): a potential mechanism of PKC isozyme regulation. Biochemistry, 39:10319–10329. 2000.
WhitingPH, KalansooriyaA, HolbrookI, HaddadF, JenningsPE. The relationship between chronic glycaemic control and oxidative stress in type 2 diabetes mellitus. Br J Biomed Sci, 65:71–74. 2008.
298.
WilcoxKC, ZhouL, JordonJK, HuangY, YuY, RedlerRL, ChenX, CaplowM, DokholyanNV. Modifications of superoxide dismutase (SOD1) in human erythrocytes: a possible role in amyotrophic lateral sclerosis. J Biol Chem, 284:13940–13947. 2009.
299.
WinklerIG, HendyJ, CoughlinP, HorvathA, LevesqueJP. Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. J Exp Med, 201:1077–1088. 2005.
300.
WoutersMA, FanSW, HaworthNL. Disulfides as redox switches: from molecular mechanisms to functional significance. Antioxid Redox Signal, 12:53–91. 2010.
301.
WuY, FanY, XueB, LuoL, ShenJ, ZhangS, JiangY, YinZ. Human glutathione S-transferase P1–1 interacts with TRAF2 and regulates TRAF2-ASK1 signals. Oncogene, 25:5787–5800. 2006.
302.
WyttenbachA, SauvageotO, CarmichaelJ, Diaz-LatoudC, ArrigoAP, RubinszteinDC. Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin. Hum Mol Genet, 11:1137–1151. 2002.
303.
XiongY, PetersonPL, LeeCP. Effect of N-acetylcysteine on mitochondrial function following traumatic brain injury in rats. J Neurotrauma, 16:1067–1082. 1999.
304.
XiongY, ShieFS, ZhangJ, LeeCP, HoYS. The protective role of cellular glutathione peroxidase against trauma-induced mitochondrial dysfunction in the mouse brain. J Stroke Cerebrovasc Dis, 13:129–137. 2004.
305.
XuX, StambrookPJ. Two murine GSTpi genes are arranged in tandem and are differentially expressed. J Biol Chem, 269:30268–30273. 1994.
306.
YangTT, HsuCT, KuoYM. Cell-derived soluble oligomers of human amyloid-beta peptides disturb cellular homeostasis and induce apoptosis in primary hippocampal neurons. J Neural Transm, 116:1561–1569. 2009.
307.
YaoD, BrownleeM. Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands. Diabetes, 59:249–255. 2010.
308.
YapLP, GarciaJV, HanDS, CadenasE. Role of nitric oxide-mediated glutathionylation in neuronal function. Potential regulation of energy utilization. Biochem J, 428:85–93. 2010.
309.
YavuzBB, YavuzB, HalilM, CankurtaranM, UlgerZ, CankurtaranES, AytemirK, AriogulS. Serum elevated gamma glutamyltransferase levels may be a marker for oxidative stress in Alzheimer's disease. Int Psychogeriatr, 20:815–823. 2008.
310.
YinZ, IvanovVN, HabelhahH, TewK, RonaiZ. Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases. Cancer Res, 60:4053–4057. 2000.
311.
YuCX, LiS, WhortonAR. Redox regulation of PTEN by S-nitrosothiols. Mol Pharmacol, 68:847–854. 2005.
312.
ZeevalkGD, ManzinoL, SonsallaPK, BernardLP. Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: relevance to Parkinson's disease. Exp Neurol, 203:512–520. 2007.
313.
ZhouSG, WangP, PiRB, GaoJ, FuJJ, FangJ, QinJ, ZhangHJ, LiRF, ChenSR, TangFT, LiuPQ. Reduced expression of GSTM2 and increased oxidative stress in spontaneously hypertensive rat. Mol Cell Biochem, 309:99–107. 2008.
314.
ZhuY, CarveyPM, LingZ. Age-related changes in glutathione and glutathione-related enzymes in rat brain. Brain Res, 1090:35–44. 2006.
315.
ZhukovaL, ZhukovI, BalW, Wyslouch-CieszynskaA. Redox modifications of the C-terminal cysteine residue cause structural changes in S100A1 and S100B proteins. Biochim Biophys Acta, 1742:191–201. 2004.
316.
ZouZ, AnisowiczA, HendrixMJ, ThorA, NeveuM, ShengS, RafidiK, SeftorE, SagerR. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science, 263:526–529. 1994.