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References
1.
AmbroseJA, BaruaRS. The pathophysiology of cigarette smoking and cardiovascular disease: an update. J Am Coll Cardiol, 43:1731–1737. 2004.
2.
BagiZ, CsekoC, TothE, KollerA. Oxidative stress-induced dysregulation of arteriolar wall shear stress and blood pressure in hyperhomocysteinemia is prevented by chronic vitamin C treatment. Am J Physiol Heart Circ Physiol, 285:H2277–2283. 2003.
BerkBC. Atheroprotective signaling mechanisms activated by steady laminar flow in endothelial cells. Circulation, 117:1082–1089. 2008.
5.
BooYC, HwangJ, SykesM, MichellBJ, KempBE, LumH, JoH. Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism. Am J Physiol Heart Circ Physiol, 283:H1819–H1828. 2002.
6.
BooYC, JoH. Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases. Am J Physiol Cell Physiol, 285:C499–C508. 2003.
7.
BraamB, VerhaarMC. Understanding eNOS for pharmacological modulation of endothelial function: a translational view. Curr Pharm Des, 13:1727–1740. 2007.
8.
CarpH, JanoffA. Possible mechanisms of emphysema in smokers: in vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants. Am Rev Respir Dis, 118:617–621. 1978.
9.
CelermajerDS. Endothelial dysfunction: Does it matter? Is it reversible?J Am Coll Cardiol, 30:325–333. 1997.
10.
ChavakisE, DernbachE, HermannC, MondorfUF, ZeiherAM, DimmelerS. Oxidized LDL inhibits vascular endothelial growth factor-induced endothelial cell migration by an inhibitory effect on the Akt/endothelial nitric oxide synthase pathway. Circulation, 103:2102–2107. 2001.
11.
ConklinDJ, HaberzettlP, ProughRA, BhatnagarA. Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke. Am J Physiol Heart Circ Physiol, 296:H1586–H1597. 2009.
12.
CorsonMA, JamesNL, LattaSE, NeremRM, BerkBC, HarrisonDG. Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ Res, 79:984–991. 1996.
13.
DaiG, VaughnS, ZhangY, WangET, Garcia-CardenaG, GimbroneMA.Jr. Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2. Circ Res, 101:723–733. 2007.
14.
Dalle-DonneI, ScaloniA, GiustariniD, CavarraE, TellG, LungarellaG, ColomboR, RossiR, MilzaniA. Proteins as biomarkers of oxidative/nitrosative stress in diseases: the contribution of redox proteomics. Mass Spectrom Rev, 24:55–99. 2005.
FlemingI, FisslthalerB, DixitM, BusseR. Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells. J Cell Sci, 118:4103–4111. 2005.
19.
Gimbrone MAJr, CotranRS, FolkmanJ. Human vascular endothelial cells in culture: growth and DNA synthesis. J Cell Biol, 60:673–684. 1974.
20.
Gimbrone MAJr, NagelT, TopperJN. Biomechanical activation: an emerging paradigm in endothelial adhesion biology. J Clin Invest, 99:1809–1813. 1997.
21.
GuzikTJ, WestNE, PillaiR, TaggartDP, ChannonKM. Nitric oxide modulates superoxide release and peroxynitrite formation in human blood vessels. Hypertension, 39:1088–1094. 2002.
22.
HeitzerT, Yla-HerttualaS, LuomaJ, KurzS, MunzelT, JustH, OlschewskiM, DrexlerH. Cigarette smoking potentiates endothelial dysfunction of forearm resistance vessels in patients with hypercholesterolemia: role of oxidized LDL. Circulation, 93:1346–1353. 1996.
23.
HermannC, AssmusB, UrbichC, ZeiherAM, DimmelerS. Insulin-mediated stimulation of protein kinase Akt: a potent survival signaling cascade for endothelial cells. Arterioscler Thromb Vasc Biol, 20:402–409. 2000.
24.
HiraiN, KawanoH, HirashimaO, MotoyamaT, MoriyamaY, SakamotoT, KugiyamaK, OgawaH, NakaoK, YasueH. Insulin resistance and endothelial dysfunction in smokers: effects of vitamin C. Am J Physiol Heart Circ Physiol, 279:H1172–H1178. 2000.
25.
JinZG, UebaH, TanimotoT, LunguAO, FrameMD, BerkBC. Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase. Circ Res, 93:354–363. 2003.
26.
JinZG, WongC, WuJ, BerkBC. Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells. J Biol Chem, 280:12305–12309. 2005.
27.
KasaharaY, TuderRM, CoolCD, LynchDA, FloresSC, VoelkelNF. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med, 163:737–744. 2001.
28.
KasaharaY, TuderRM, Taraseviciene-StewartL, Le CrasTD, AbmanS, HirthPK, WaltenbergerJ, VoelkelNF. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest, 106:1311–1319. 2000.
KodeA, RajendrasozhanS, CaitoS, YangSR, MegsonIL, RahmanI. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol, 294:L478–L488. 2008.
31.
KrollJ, WaltenbergerJ. A novel function of VEGF receptor-2 (KDR): rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cells. Biochem Biophys Res Commun, 265:636–639. 1999.
32.
KurtagicE, JedrychowskiMP, NugentMA. Neutrophil elastase cleaves VEGF to generate a VEGF fragment with altered activity. Am J Physiol Lung Cell Mol Physiol, 296:L534–L546. 2009.
33.
LeeJH, LeeDS, KimEK, ChoeKH, OhYM, ShimTS, KimSE, LeeYS, LeeSD. Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. Am J Respir Crit Care Med, 172:987–993. 2005.
34.
LiebowAA. Pulmonary emphysema with special reference to vascular changes. Am Rev Respir Dis, 80:67–93. 1959.
35.
MarwickJA, StevensonCS, GiddingsJ, MacNeeW, ButlerK, RahmanI, KirkhamPA. Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition. Am J Physiol Lung Cell Mol Physiol, 290:L897–L908. 2006.
36.
MercadoC, JaimesEA. Cigarette smoking as a risk factor for atherosclerosis and renal disease: novel pathogenic insights. Curr Hypertens Rep, 9:66–72. 2007.
37.
MichaudSE, DussaultS, GroleauJ, HaddadP, RivardA. Cigarette smoke exposure impairs VEGF-induced endothelial cell migration: role of NO and reactive oxygen species. J Mol Cell Cardiol, 41:275–284. 2006.
38.
MoodieFM, MarwickJA, AndersonCS, SzulakowskiP, BiswasSK, BauterMR, KiltyI, RahmanI. Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells. FASEB J, 18:1897–1899. 2004.
39.
MoroiM, ZhangL, YasudaT, VirmaniR, GoldHK, FishmanMC, HuangPL. Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice. J Clin Invest, 101:1225–1232. 1998.
40.
MullerT, HaussmannHJ, SchepersG. Evidence for peroxynitrite as an oxidative stress-inducing compound of aqueous cigarette smoke fractions. Carcinogenesis, 18:295–301. 1997.
41.
NakamuraT, LiptonSA. Molecular mechanisms of nitrosative stress-mediated protein misfolding in neurodegenerative diseases. Cell Mol Life Sci, 64:1609–1620. 2007.
42.
NeunteuflT, HeherS, KostnerK, MitulovicG, LehrS, KhoschsorurG, SchmidRW, MaurerG, StefenelliT. Contribution of nicotine to acute endothelial dysfunction in long-term smokers. J Am Coll Cardiol, 39:251–256. 2002.
PeluffoG, CalcerradaP, PiacenzaL, PizzanoN, RadiR. Superoxide-mediated inactivation of nitric oxide and peroxynitrite formation by tobacco smoke in vascular endothelium: studies in cultured cells and smokers. Am J Physiol Heart Circ Physiol, 296:H1781–H1792. 2009.
45.
PryorWA, StoneK. Oxidants in cigarette smoke: radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite. Ann N Y Acad Sci, 686:12–27; discussion 27–18. 1993.
RaijL, DeMasterEG, JaimesEA. Cigarette smoke-induced endothelium dysfunction: role of superoxide anion. J Hypertens, 19:891–897. 2001.
48.
RangasamyT, ChoCY, ThimmulappaRK, ZhenL, SrisumaSS, KenslerTW, YamamotoM, PetracheI, TuderRM, BiswalS. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest, 114:1248–1259. 2004.
49.
SakaoS, Taraseviciene-StewartL, CoolCD, TadaY, KasaharaY, KurosuK, TanabeN, TakiguchiY, TatsumiK, KuriyamaT, VoelkelNF. VEGF-R blockade causes endothelial cell apoptosis, expansion of surviving CD34+ precursor cells and transdifferentiation to smooth muscle-like and neuronal-like cells. FASEB J, 21:3640–3652. 2007.
50.
Schmidt-LuckeC, BelgoreF, ReinholdD, AnsorgeS, KleinHU, Schmidt-LuckeJA, LipGY. Soluble vascular endothelial growth factor, soluble VEGF receptor Flt-1 and endothelial function in healthy smokers. Int J Cardiol, 100:207–212. 2005.
51.
SoghomoniansA, ThirkillTL, MarianoNF, BarakatAI, DouglasGC. Effect of aqueous tobacco smoke extract and shear stress on PECAM-1 expression and cell motility in human uterine endothelial cells. Toxicol Sci, 81:408–418. 2004.
52.
SuY, HanW, GiraldoC, De LiY, BlockER. Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells. Am J Respir Cell Mol Biol, 19:819–825. 1998.
TuderRM, ZhenL, ChoCY, Taraseviciene-StewartL, KasaharaY, SalveminiD, VoelkelNF, FloresSC. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am J Respir Cell Mol Biol, 29:88–97. 2003.
55.
Ushio-FukaiM. VEGF signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal, 9:731–739. 2007.
56.
WagnerL, LaczyB, TamaskoM, MazakI, MarkoL, MolnarGA, WagnerZ, MohasM, CsehJ, FeketeA, WittmannI. Cigarette smoke-induced alterations in endothelial nitric oxide synthase phosphorylation: role of protein kinase C. Endothelium, 14:245–255. 2007.
57.
WooKS, RobinsonJT, ChookP, AdamsMR, YipG, MaiZJ, LamCW, SorensenKE, DeanfieldJE, CelermajerDS. Differences in the effect of cigarette smoking on endothelial function in Chinese and white adults. Ann Intern Med, 127:372–375. 1997.
58.
WrightJL, CosioM, ChurgA. Animal models of chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol, 295:L1–L15. 2008.
59.
WrightJL, TaiH, ChurgA. Vasoactive mediators and pulmonary hypertension after cigarette smoke exposure in the guinea pig. J Appl Physiol, 100:672–678. 2006.
60.
YamatoH, SunJP, ChurgA, WrightJL. Cigarette smoke-induced emphysema in guinea pigs is associated with diffusely decreased capillary density and capillary narrowing. Lab Invest, 75:211–219. 1996.
61.
YangSR, ChidaAS, BauterMR, ShafiqN, SeweryniakK, MaggirwarSB, KiltyI, RahmanI. Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. Am J Physiol Lung Cell Mol Physiol, 291:L46–L57. 2006.
62.
YuC, RahmaniM, AlmenaraJ, SausvilleEA, DentP, GrantS. Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process. Oncogene, 23:1364–1376. 2004.
63.
ZeiherAM. Endothelial vasodilator dysfunction: pathogenetic link to myocardial ischaemia or epiphenomenon?Lancet, 348,suppl 1:s10–s12. 1996.
