Antisense Sequences of 20-kDa Homologous Restriction Factor (HRF20) Are Found in C9 and the C8 β Chain of Homologous Complement

Abstract

We examined, on the basis of the fact that sense and antisense peptides have affinity for each other, whether any relationship exists between homologous restriction factor (HRF20), a membrane inhibitor of the terminal stage of homologous complement attack, and the antisense sequence of the terminal complement components C8 and C9. In this article, we demonstrate that there are two regions of C9 that contain antisense sequences to one continuous region of HRF20 and that this relationship exists between human HRF20 and human C9, but not mouse C9. We also found one region of the C8 β chain that contains an antisense sequence to HRF20.