A novel HIV-1 unique recombinant virus (XC2014EU20) was identified. It was isolated from an HIV-positive man who was infected through heterosexual sex in Sichuan, China. The near full-length genome analyses showed that the novel recombinant was composed of three subtype B regions in a subtype C backbone. Different from the other circulating recombinant forms and unique recombinant forms, six recombinant breakpoints of XC2014EU20 with seven fragments were observed in the pol, vpu, and nef genes, respectively. The emergence of B/C recombinant strain indicated the increasing complexity of the HIV-1 epidemic in Sichuan, China.
Get full access to this article
View all access options for this article.
References
1.
HeX, XingH, RuanY, et al.: A comprehensive mapping of HIV-1 genotypes in various risk groups and regions across China based on a nationwide molecular epidemiologic survey. PLoS One, 2012; 7:e47289.
2.
SuL, GrafM, ZhangY, et al.: Characterization of a virtually full-length human immunodeficiency virus type 1 genome of a prevalent intersubtype (C/B′) recombinant strain in China. J Virol, 2000; 74:11367–11376.
3.
PiyasirisilpS, McCutchanFE, CarrJK, et al.: A recent outbreak of human immunodeficiency virus type 1 infection in southern China was initiated by two highly homogeneous, geographically separated strains, circulating recombinant form AE and a novel BC recombinant. J Virol, 2000; 74:11286–11295.
4.
WeiH, LiuY, FengY, et al.: Genome sequence of a novel HIV-1 circulating recombinant form (CRF57_BC) identified from Yunnan, China. AIDS Res Hum Retroviruses, 2014; 30:384–388.
5.
LiX, NingC, HeX, et al.: Genome sequences of a novel HIV-1 circulating recombinant form (CRF61_BC) identified among heterosexuals in China. Genome Announc, 2013; 1:e00326-13.
6.
WeiH, HisJ, FengY, et al.: Identification of a novel HIV-1 circulating recombinant form (CRF62_BC) in western Yunnan of China. AIDS Res Hum Retroviruses, 2014; 30:380–383.
7.
HsiJ, WeiH, XingH, et al.: Genome sequence of a novel HIV-1 circulating recombinant form (CRF64_BC) identified from Yunnan, China. AIDS Res Hum Retroviruses, 2014; 30:384–388.
8.
HallTA. BioEdit: A user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl Acids Symp Ser, 1999; 41:95–98.
LoleK, BollingerR, Rs, GadkariD, et al.: Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J Virol, 1999; 73:152–160.
