Sage Journals: Discover world-class research

Abstract

The tumor necrosis factor-α (TNF-α)-308G/A gene polymorphism influences the pathogenesis and evolution of HIV-1 disease. Many studies have evaluated the association between this polymorphism and HIV-1 susceptibility, but the exact relationship between them remains ambiguous and contradictory. Accordingly, the present study evaluates the exact association between TNF-α-308G/A gene polymorphism and HIV-1 susceptibility. A systematic literature search was conducted and the case-control studies that were found assessing the association between TNF-α-308G/A gene polymorphism and HIV-1 susceptibility were analyzed. The pooled odds ratios (ORs) and 95% confidence interval (CI) were calculated by a fixed effect model. Heterogeneity was analyzed by Cochran's Q and the I² statistics. Publication bias was assessed using the Begg's funnel plot and Egger's test. A total of 679 cases and 873 controls from five studies were included. Overall, no significant relationship was found between TNF-α-308G/A gene polymorphism and HIV-1 susceptibility in this meta-analysis study (A versus G genotype model: OR=0.89, 95% CI=0.59–1.32, p=0.553; GG versus AA+AG model: OR=1.23, 95% CI=0.75–2.02, p=0.407; GG+AG versus AA model: OR=1.40, 95% CI=0.70–2.82, p=0.345; GG versus AA model: OR=1.39, 95% CI=0.69–2.80, p=0.362; AG versus AA model: OR=1.43, 95% CI=0.70–2.96, p=0.329; GG+AA versus AG model: OR=0.76, 95% CI=0.44–1.29, p=0.304). The meta-analysis found no marked association between TNF-α-308G/A gene polymorphism and HIV-1 susceptibility.

Get full access to this article

View all access options for this article.

References

Gottlieb

: Pneumocystis pneumonia–Los Angeles. Am J Public Health, 1981; 96(6):982–983.

Cabezas

, Fornasini

, Dardenne

, et al.: A cross-sectional study to assess knowledge about HIV/AIDS transmission and prevention measures in company workers in Ecuador. BMC Public Health, 2013; 13:139.

WHO: www.who.int/hiv/data/en/ (2013).

Fellay

, Shianna

, Ge

, et al.: A whole-genome association study of major determinants for host control of HIV-1. Science, 2007; 317(5840):944–947.

Nasi

, Riva

, Boberto

, et al.: Novel genetic association of TNF-α-238 and PDCD1-7209 polymorphisms with long-term non-progressive HIV-1 infection. Int J Infect Dis, 2013; 17:e845–e850.

Kedzierska

and Crowe

: Cytokines and HIV-1: Interactions and clinical implications. Antiviral Chem Chemother, 2001; 12:133–150.

, Xue

, Yan

, et al.: Association between tumor necrosis factor-α 308G/A gene polymorphism and silicosis susceptibility: A meta-analysis. PLoS One, 2013; 8(10):e76614.

van

Manen

, Wout

, and Schuitemaker

: Genome-wide association studies on HIV susceptibility, pathogenesis and pharmacogenomics. Retrovirology, 2012; 9:70.

Gounden

, Moodley

, Chuturgoon

, et al.: Association of −308 TNF-alpha promoter polymorphism with viral load and CD4 T-helper cell apoptosis in HIV-1 infected black South Africans. SAJ HIV MED, 2012; 13(2):72–77.

10.

Veloso

, Olona

, Garcia

, et al.: Effect of TNF-α genetic variants and CCR5Δ32 on the vulnerability to HIV-1 infection and disease progression in Caucasian Spaniards. BMC Med Genet, 2010; 11:63.

11.

Singh

, Sharma

, and Arora

: High producer haplotype (CAG) of −863C/A, −308G/A and −238G/A polymorphisms in the promoter region of TNF-α gene associated with enhanced apoptosis of lymphocytes in HIV-1 subtype C infected individuals from North India. PLoS One, 2014; 9(5):e98020.

12.

Freitas

, Lima

, Feitosa

RNM

, et al. Polymorphisms in the IFNγ, IL-10, and TGFβ genes may be associated with HIV-1 infection. Disease Markers, 2015:248571.

13.

Konenkov

and Smol'nikova

: Polymorphism of promotor sites of interleukins-4 and −10 and tumor necrosis factor-α genes in HIV-infected patients. Bull Exp Biol Med, 2002; 133(4):449–951.

14.

Knuchel

, Spira

, Neumann

, et al.: Analysis of a biallelic polymorphism in the tumor necrosis factor a promoter and HIV type 1 disease progression. AIDS Res Hum Retroviruses, 1998; 14(4):305–309.

15.

Higgins

, Thompson

, Deeks

, et al.: Measuring inconsistency in meta-analyses. BMJ, 2003; 327:557–560.

16.

Brittain

, Fay

, and Follmann

DAA

: Valid formulation of the analysis of noninferiority trials under random effects meta-analysis. Biostatistics, 2012; 13:637–649.

17.

Chootrakool

, Shi

, and Yue: Meta-analysis and sensitivity analysis for multi-arm trials with selection bias. Stat Med, 2011; 30:1183–1198.

18.

Munafò

, Clark

, and Flint

: Assessing publication bias in genetic association studies: Evidence from a recent meta-analysis. Psychiatry Res, 2004; 129:39–44.

19.

Begg

and Mazumdar

: Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994; 50:1088–1101.

20.

Egger

, Davey Smith

, Schneider

, et al.: Bias in meta-analysis detected by a simple, graphical test. BMJ (Clinical Research ed.), 1997; 315:629–634.

21.

Erikstrup

, Kallestrup

, Gutsire

, et al.: Reduced mortality and CD4 cell loss among carriers of the interleukin-10 S1082G allele in a Zimbabwean cohort of HIV-1-infected adults. AIDS, 2007; 12(17):2283–2291.

22.

Wang

, Song

, Lobashevsky

, et al.: Cytokine and chemokine gene polymorphisms among ethnically diverse North Americans with HIV-1 infection. J Acquir Immune Defic Syndr, 2004; 35(5):446–454.

23.

Shimizu

, Miyazaki

, Ibuki

, et al.: Induction of immune response in macaque monkeys infected with simian–human immunodeficiency virus having the TNF-α gene at an early stage of infection. Virology, 2005; 343:151–161.

24.

Simpson

, Moysi

, Wicks

, et al.: Functional differences exist between TNFα promoters encoding the common 2237G SNP and the rarer HLAB*5701-linked A variant. PLoS One, 2012; 7(7):e40100.

25.

Piddubna

and Chemych

: IL-4, IL-10, TNF-α profile and immunological changes in North-Eastern Ukrainian HIV-infected individuals. HIV AIDS Rev, 2013; 12:68–72.

26.

Quasney

, Zhang

, Sargent

, et al.: Increased frequency of the tumor necrosis factor-α-308 A allele in adults with human immunodeficiency virus dementia. Ann Neurol, 2001; 50(2):157–162.

27.

Folks

, Clouse

, Justement

, et al.: Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone. Proc Natl Acad Sci USA, 1989; 86(7):2365–2368.

28.

Poli

, Kinter

, Justement

, et al.: Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression. Proc Natl Acad Sci USA, 1990; 87(2):782–785.

29.

Kfutwah

AKW

, Mary

, Nicola

, et al.: Tumour necrosis factor-α stimulates HIV-1 replication in single-cycle infection of human term placental villi fragments in a time, viral dose and envelope dependent manner. Retrovirology, 2006; 3:36.

30.

Badley

, Dockrell

, Simpson

, et al.: Macrophage-dependent apoptosis of CD4⁺ T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor. J Exp Med, 1997; 185(1):55–64.

31.

Herbein

and Gordon

: 55- and 75-kilodalton tumor necrosis factor receptors mediate distinct actions in regard to human immunodeficiency virus type 1 replication in primary human macrophages. J Virol, 1997; 71(5):4150–4156.

32.

Vaidya

, Korner

, Sirignano

, et al.: Tumor necrosis factor α is associated with viral control and early disease progression in patients with HIV type 1 infection. J Infect Dis, 2014; 210(7):1042–1046.

33.

Griffin

, Leung

, Folks

, et al.: Induction of NF-kappa B during monocyte differentiation is associated with activation of HIV-gene expression. Res Virol, 1991; 142(2–3):233–238.

34.

Deghaide

NHS

, Rodrigues

MLV

, Castelli

, et al.: Tumor necrosis factor region polymorphisms are associated with AIDS and with cytomegalovirus retinitis. AIDS, 2009; 23(13):1641–1647.

35.

Delgado

, Leung

, Baena

, et al.: The-1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia. Immunogenetics, 2003; 55:497–501.

36.

Chaudhari

, Chavan

, and Kerkar

: Polymorphisms in major cytokine genes: A study among human immunodeficiency virus-1 serodiscordant couples in Mumbai, India. Ind J Med Microbiol, 2013; 31(2):166–172.

37.

Brinkman

BMN

, Keet

IPM

, Miedema

, et al.: Polymorphisms within the human tumor necrosis factor-α promoter region in human immunodeficiency virus type 1-seropositive persons. J Infect Dis, 1997; 175(1):188–190.

38.

Zhang

, Zhu

, Pu

, et al.: Association between tumor necrosis factor alpha- 238G/a polymorphism and tuberculosis susceptibility: A meta-analysis study. BMC Infect Dis, 2012; 12:328.

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.00 MB

0.02 MB

Association Between the Tumor Necrosis Factor-α-308G/A Gene Polymorphism and HIV-1 Susceptibility: A Meta-Analysis

Abstract

Get full access to this article

References

Supplementary Material