We previously reported a significant decrease in HIV-1 prevalence, with no increase in drug-resistant HIV-1 among injecting drug users (IDU), female sex workers (FSW), and blood donors (BD), in Haiphong, Vietnam, from 2007 to 2009. In 2012, 388 IDU, 51 FSW, and 200 BD were recruited for further analysis. None had a history of antiretroviral treatment. From 2007 to 2012, HIV-1 prevalence was reduced from 35.9% to 18.6% (p<0.001), 23.1% to 9.8% (p<0.05), and 2.9% to 1% (p=0.29) in IDU, FSW, and BD, respectively. Of 79 anti-HIV-1 antibody-positive samples, 61 were successfully analyzed for the pol-reverse transcriptase (RT) region. All HIV-1 strains were CRF01_AE. Nonnucleoside RT inhibitor-resistant mutations, Y181C/I, were detected in three subjects; one had the nucleoside RT inhibitor-resistant mutations L74V and M184V and one had E138K. The prevalence of transmitted drug-resistant HIV-1 in Haiphong increased slightly from 1.8% in 2007 to 6.6% in 2012 (p=0.06).
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References
1.
National Committee for AIDS, Drug and Prostitution Prevention and Control, Ministry of Health, Socialist Republic of Viet Nam: Viet Nam AIDS response report 2014. Following up the 2011 political declaration on HIV AIDS. Reporting period, January 2012–December 2013. 2014. Available at www.unaids.org/sites/default/files/en/dataanalysis/knowyourresponse/countryprogressrep.orts/2014countries/VNM_narrative_report_2014.pdf. Accessed March14, 2015.
2.
National Committee for AIDS, Drugs, and Prostitution Prevention and Control, Ministry of Health, Socialist Republic of Viet Nam: Viet Nam AIDS response progress report, 2012. Following up the 2011 political declaration on HIV/AIDS. Reporting period, January 2010–December 2011. 2012. Available at www.unaids.org/sites/default/files/en/dataanalysis/knowyourresponse/countryprogressreports/2012countries/ce_VN_Narrative_Report.pdf. Accessed March14, 2015.
3.
PhamQD, WilsonDP, LawMG, et al.: Global burden of transmitted HIV drug resistance and HIV-exposure categories: A systematic review and meta-analysis. AIDS, 2014; 28(18):2751–2762.
4.
IshizakiA, CuongN, ThucP, et al.: Profile of HIV type 1 infection and genotypic resistance mutations to antiretroviral drugs in treatment-naive HIV type 1-infected individuals in Hai Phong, Viet Nam. AIDS Res Hum Retroviruses, 2009; 25(2):175–182.
5.
TranVT, IshizakiA, NguyenCH, et al.: No increase of drug-resistant HIV type 1 prevalence among drug-naive individuals in Northern Vietnam. AIDS Res Hum Retroviruses, 2012; 28(10):1349–1351.
6.
NguyenH, DucN, ShrivastavaR, et al.: HIV drug resistance threshold survey using specimens from voluntary counselling and testing sites in Hanoi, Vietnam. Antivir Ther, 2008; 13(Suppl 2):115–121.
7.
AyoubaA, LienT, NouhinJ, et al.: Low prevalence of HIV type 1 drug resistance mutations in untreated, recently infected patients from Burkina Faso, Côte d'Ivoire, Senegal, Thailand, and Vietnam: The ANRS 12134 study. AIDS Res Hum Retroviruses, 2009; 25(11):1193–1196.
8.
PhanT, IshizakiA, PhungD, et al.: Characterization of HIV type 1 genotypes and drug resistance mutations among drug-naive HIV type 1-infected patients in Northern Vietnam. AIDS Res Hum Retroviruses, 2010; 26(2):233–235.
9.
DeanJ, Ta ThiTH, DunfordL, et al.: Prevalence of HIV type 1 antiretroviral drug resistance mutations in Vietnam: A multicenter study. AIDS Res Hum Retroviruses, 2011; 27(7):797–801.
10.
ThaoVP, LeT, TörökEM, et al.: HIV-1 drug resistance in antiretroviral-naive individuals with HIV-1-associated tuberculosis meningitis initiating antiretroviral therapy in Vietnam. Antivir Ther, 2012; 17(5):905–913.
11.
DucNB, HienBT, WagarN, et al.: Surveillance of transmitted HIV drug resistance using matched plasma and dried blood spot specimens from voluntary counseling and testing sites in Ho Chi Minh City, Vietnam, 2007–2008. Clin Infect Dis, 2012; 54(Suppl 4):S343–347.
12.
TanumaJ, QuangVM, HachiyaA, et al.: Low prevalence of transmitted drug resistance of HIV-1 during 2008–2012 antiretroviral therapy scaling up in Southern Vietnam. J Acquir Immune Defic Syndr, 2014; 66(4):358–364.
13.
PhamQD, DoNT, LeYN, et al.: Pretreatment HIV-1 drug resistance to first-line drugs: Results from a baseline assessment of a large cohort initiating ART in Vietnam, 2009–10. J Antimicrob Chemother, 2015; 70(3):941–947.
14.
WensingAM, CalvezV, GünthardHF, et al.: 2014 update of the drug resistance mutations in HIV-1. Top Antivir Med, 2014; 22(3):642–650.
15.
Ministry of Health, Socialist Republic of Viet Nam: Guidelines for HIV/AIDS Diagnosis and Treatment (No. 3003/QD-BYT). 2009.
16.
Ministry of Health, Socialist Republic of Viet Nam: Guidelines for HIV/AIDS Diagnosis and Treatment (No. 4139/QD-BYT). 2011.
17.
PhamH, IshizakiA, NguyenL, et al.: Two-year outcome of first-line antiretroviral therapy among HIV-1 vertically infected children in Hanoi, Vietnam. Int J STD AIDS, 2014; pii: 0956462414556328. [Epub ahead of print]
18.
WangY, XingH, LiaoL, et al.: The development of drug resistance mutations K103N Y181C and G190A in long term nevirapine-containing antiviral therapy. AIDS Res Ther, 2014; 11:36.
19.
PhanC, PhamH, BiX, et al.: Genetic analyses of HIV-1 strains transmitted from mother to child in Northern Vietnam. AIDS Res Hum Retroviruses [Epub ahead of print];DOI:10.1089/aid.2014.0335.
